Proleukin in Combination With Rituxan in Patients With Low-Grade Non-Hodgkin's Lymphoma Who Have Previously Failed Rituxan Treatments
Lymphoma, Non-Hodgkin
About this trial
This is an interventional treatment trial for Lymphoma, Non-Hodgkin focused on measuring Low-Grade or Follicular Non-Hodgkin's Lymphoma
Eligibility Criteria
Diagnosis and disease status: Subjects with CD20+, B-cell, Non-Hodgkin's lymphoma of low-grade or follicular histology with measurable relapsed or unresponsive disease after prior therapy; mantle cell and chronic lymphocytic leukemia subtypes are excluded. Subjects who previously received a single-agent course of rituximab and showed no tumor response, or had a response lasting < 6 months. The previously administered rituximab must have included at least 75% of the standard 4-week regimen (4 x 375 mg/m2). A record of the previous rituximab treatment and response must be available as a source document at the site. Exclusion: Subjects who showed no tumor response or a response lasting <6 months to treatment with Rituximab in combination with Chemotherapy or another therapeutic modality (radiation or radioimmunoconjugates). HIV positive. Symptomatic thyroid disease requiring medical intervention other than replacement treatment for hypothyroidism. Clinically significant cardiac, pulmonary, and /or hepatic dysfunction (if subject has history of congestive heart failure or myocardial infarction, must have been stable for at least 6 months, and have no current symptoms If cardiac ejection fraction has been measured, it must be greater than 50%.
Sites / Locations
- University of Arkansas for Medical Sciences
- Comprehensive Blood and Cancer Center
- California Oncology of the Central Valley
- Virginia K. Crosson Cancer Center
- Pacific Shores Medical Group
- Wilshire Oncology Medical Group
- California Cancer Care Inc.
- Pacific Shores Medical Group
- Santa Barbara Hematology Oncology Medical Group
- Pacific Shores Medical Group
- Pacific Shores Medical Group
- UCLS Medical Center
- Facey Medical Foundation
- North Valley Hematology-Oncology Medical Group
- Hoag Cancer Center
- North Valley Hematology/Oncology Medical Group
- Ventura County Hematology-Oncology Specialists
- UCLA Medical Group/Pasadena Oncology
- Wilshire Oncology Medical Group
- Wilshire Oncology Medical Group
- Southwest Cancer Care
- Wilshire Oncology Medical Group
- Cancer Care Associates Meidcal Group, Inc.
- UC Davis Cancer Center
- Sansum Santa Barbara Foundation Medical Clinic
- Santa Barbara Hematology Oncology Medical Group, Inc.
- Santa Barbara Hematology Oncology Medical Group
- John Wayne Cancer Institute
- Santa Barbara Hematology Oncology Medical Group
- Cancer Care Associates Medical Group, Inc.
- UCLA/Santa Clarita Valley Cancer Center
- Ventura County Hematology-Oncology Specialists
- San Diego Cancer Center Medical Group
- Wilshire Oncology Medical Group
- Whittingham Cancer Center
- Division of Hematology/Oncology, University of Miami, School of Medicine
- Cancer Research Center of Hawaii
- Northwestern University Medical School
- Oncology Specialists,S.C.
- Cancer Care Center
- Indiana Oncology and Hematology Consultants
- University of Iowa Hospitals and Clinics
- Consultants in Blood Disorders and Cancer
- Hematology and Oncology Specialists, LLC
- Louisiana State University Health Sciences Center and VA
- Maine Center for Cancer Medicine & Blood Disorders
- Kansas City Oncology and Hematology Group
- Benefis Healthcare
- Comprehensive Cancer Centers of Nevada
- Comprehensive Cancer Centers of Nevada
- Northern New Jersey Cancer Associates
- Erie County Medical Center
- Advanced Oncology Associates
- Weill Medical College of Cornell University/New York Presbyterian Hospital
- Mount Sinai School of Medicine
- East Carolina University School of Medicine, Department of Medicine, Division of Hematology/Oncology
- Gabrail Cancer Center
- The Cleveland Clinic Foundation
- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
- Hematology Oncology Consultants, Inc.
- Oregon Health & Science University
- Cancer Centers of the Carolinas
- Germantown Cancer Foundation
- Fletcher Allen Health Care
- Virginia Cancer Institute