Donor Stem Cell Transplant With or Without Chemotherapy in Treating Children With Primary Myelodysplastic Syndrome
Leukemia, Myelodysplastic/Myeloproliferative Neoplasms
About this trial
This is an interventional diagnostic trial for Leukemia focused on measuring juvenile myelomonocytic leukemia, childhood myelodysplastic syndromes, atypical chronic myeloid leukemia, BCR-ABL1 negative, myelodysplastic/myeloproliferative neoplasm, unclassifiable, chronic myelomonocytic leukemia
Eligibility Criteria
DISEASE CHARACTERISTICS: Morphologically confirmed primary myelodysplastic syndromes (MDS) Diagnosed between July 1, 1998 and June 30, 2002 No prior aplastic anemia No prior congenital bone marrow failure syndrome, such as: Fanconi's anemia Kostmann syndrome Shwachman syndrome Dyskeratosis congenital Amegakaryocytic thrombocytopenia Diamond-Blackfan anemia No Down syndrome None of the following cytogenetic or molecular abnormalities: t(8;21)(q22;q22) t(15;17)(q22;q12) inv(16)(p13;q22) No typical clinical and cytogenetic features of acute myeloid leukemia FAB M7 (i.e., acute megakaryocytic leukemia) with fewer than 30% blasts in bone marrow or peripheral blood PATIENT CHARACTERISTICS: Age Under 19 Performance status Not specified Life expectancy Not specified Hematopoietic See Disease Characteristics Hepatic Not specified Renal Not specified Other No other concurrent illness that would preclude study PRIOR CONCURRENT THERAPY: Biologic therapy Not specified Chemotherapy No prior chemotherapy for MDS Endocrine therapy Not specified Radiotherapy No prior radiotherapy for MDS Surgery Not specified
Sites / Locations
- Universitaetskinderklinik - Universitaetsklinikum Freiburg