Cause and Natural Course of Pediatric-Onset Mastocytosis
Mastocytosis
About this trial
This is an observational trial for Mastocytosis focused on measuring Children, Mast Cells, Urticaria Pigmentosa, Bone Marrow, Severe, Mastocytosis, Pediatric Mastocytosis
Eligibility Criteria
INCLUSION CRITERIA: Children with tissue-diagnosed pediatric-onset mastocytosis formerly enrolled in protocols 90-I-0120, and 93-I-0136 or per physician referral with more severe disease as indicated by one of the following parameters: Hepatomegaly or splenomegaly; Diffuse cutaneous mastocytosis; History of gastrointestinal bleeding or peptic ulcer disease; Bone marrow biopsy with abnormal numbers or shaped mast cells or abnormal flow cytometry; Serum tryptase greater than 20ng/ml; Hematologic abnormalities such as an increase WBC, thrombocytosis, and/or an increase in PT and/or PTT. INCLUSION CRITERIA-SUBJECT: Age birth to 21.0 years of age at the time of entry into the protocol Diagnosis of mastocytosis by skin examination or histologic evidence in a skin or bone marrow biopsy Subject has a primary medical care provider outside the NIH Subject or parent or guardian is able to give informed consent INCLUSION CRITERIA-RELATIVE: A biological relative with or without the diagnosis of mastocytosis by skin examination or histologic evidence in a skin or bone marrow biopsy Subject has a primary medical care provider outside the NIH EXCLUSION CRITERIA SUBJECT: Age greater than or equal to 21.0 years No primary care physician Has AIDS or is HIV Positive
Sites / Locations
- National Institutes of Health Clinical Center, 9000 Rockville Pike