Ventilator-Associated Pneumonia/Hospital-Acquired Pneumonia Requiring Mechanical Ventilatory Support

Inclusion Criteria: Onset or exacerbation of pneumonia at least 72 hours after admission to an acute care facility or onset of pneumonia in a nursing home or rehabilitation facility with subsequent transfer to an acute care facility Diagnosis of hospital-acquired pneumonia requiring mechanical ventilatory support Patient or Patient's legal guardian must sign written informed consent for study participation, pretreatment, and Day 7 bronchoscopy Exclusion Criteria: Patients with hospital-acquired pneumonia caused by pathogens resistant to MERREM Patients with allergies to cephalosporins, penicillins and carbapenems Patients taking anticonvulsant therapy for a known seizure disorder Patients with lung cancer Patients with cystic fibrosis, acquired immune deficiency syndrome (AIDS), neutropenia, active tuberculosis, or patients taking immunosuppressive therapy in preparation for or following an organ transplant. Patients who are pregnant or breast feeding Patients who are unlikely to survive Patients with certain infections in another area requiring treatment with additional antibiotics Patients with other underlying conditions that would make it difficult to interpret response to study drug. Patients who have been part of another clinical study 30 days before entry into this study. Patients with hypotension (systolic BP < 85mmHg) or acidosis (arterial pH <7.25 or serum bicarbonate <15 mg/dl) despite attempts at fluid resuscitation Patients with profound hypoxia