Back to resultsEvaluation of Efficacy, Safety and Tolerability of Targretin Capsules in Patients With Advanced or Metastatic Non-small Cell Lung Cancer
Primary Purpose
Non-small Cell Lung Cancer
Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
bexarotene with carboplatin and paclitaxel
carboplatin and paclitaxel
Sponsored by
About this trial
This is an interventional treatment trial for Non-small Cell Lung Cancer focused on measuring NSCLC, Targretin, Retinoid, Bexarotene
Eligibility Criteria
Patients must have: Pathologic (histologic or cytologic) confirmation of NSCLC Stage IIIB with malignant pleural effusion or Stage IV disease At least one measurable or evaluable NSCLC lesion that has not been previously irradiated unless radiation therapy was more than three weeks prior to entry in the study and the lesion has been shown to have progressed subsequent to the radiation therapy ECOG performance status 0 or 1 Adequate organ system function Fasting serum triglycerides that are within the age-adjusted normal range (or normalized with appropriate intervention such as antilipid therapy prior to the initiation of Targretin capsule therapy). Patients must be able to complete at least four cycles of combination chemotherapy (i.e., approximately four months) Patients must not have had: Brain metastasis Prior chemotherapy for NSCLC Prior platinum-based chemotherapy for any indication
Sites / Locations
- Montgomery Cancer Center, L.L.C.
- Arizona Clinical Research Center, Inc.
- Bay Area Cancer Research Group, LLC
- Compassionate Cancer Care Medical Group, Inc.
- Pacific Coast Hematology/Oncology Medical Group, Inc.
- California Cancer Care, Inc.
- Coast Hematology and Oncology Associates
- Metropolitan Hematology/Oncology Medical Group
- Sant P. Chawla, Inc.
- UCLA Medical Center
- Sutter Gould Medical Foundation
- Medical Oncology Care Associates
- Southern California Kaiser Permanente Medical Group
- Sharp Health Care
- UCSF/Mount Zion Comprehensive Cancer Center
- Medical Group of North County, Inc., San Diego Cancer Center
- Rocky Mountain Cancer Centers - Midtown
- Eastern Connecticut Hematology & Oncology
- Georgetown University Hospital
- Washington Cancer Institute
- Comprehensive Cancer Care Specialists of Boca Raton
- University of Florida/Jacksonville
- Watson Clinic
- Oncology and Radiation Associates
- Florida Cancer Institute
- Florida Oncology Associates
- Cancer Centers of Florida, P.A.
- South Florida Oncology & Hematology Consultants
- Medical Oncology Associates of Augusta
- Georgia Oncology Partners Research & Education Foundation
- St. Luke's/Mountain State Tumor Institute (MSTI)
- Weiss Memorial Hospital
- Northwest Oncology and Hematology, SC
- Lutheran General Cancer Care Center
- Oncology/Hematology Associates of Central Illinois, P.C.
- Hematology Oncology Assoc. of Illinois
- Central Indiana Cancer Centers
- Cancer Care Center
- Michiana Hematology-Oncology
- Kansas City Oncology and Hematology Group, Kansas City Cancer Centers
- Drs. Carroll, Sheth, and Raghavan
- Southwest Oncology Associates
- APMC
- Louisiana State University Health Sciences Center
- Tulane University Health Sciences Center
- Mercy Medical Center
- Chesapeake Oncology-Hematology Associates
- Associates in Oncology/Hematology PC
- Berkshire Hematology Oncology, PC
- University of Michigan Medical Center
- Providence Cancer Institute
- St. Lukes Hospital
- Minnesota Oncology Hematology, P.A.
- Missouri Cancer Associates
- Hematology Oncology Centers of the Northern Rockies
- Montana Cancer & Infectious Disease Specialists
- Cancer and Blood Specialists of Nevada
- Nevada Cancer Center
- Dartmouth-Hitchcock Medical Center
- Orange Medical Group
- VA New Jersey Health Care System
- Hematology-Oncology Associates of Northern NJ, PA
- Somerset Hematology Oncology Associates
- University of Medicine & Dentistry of NJ, School of Osteopathic Medicine
- Overlook Oncology Center
- San Juan Oncology Associates
- New York Oncology Hematology, P.C., Capital District Hematology Oncology Associates
- Erie Medical Center
- Roswell Park Cancer Institute
- Arena Oncology Associates
- Cancer Institute of Long Island, Inc.
- Cancer Research of Long Island, Inc.
- Broome Oncology, LLC
- New York Presbyterian Hospital, Weill Medical College of Cornell University
- Columbia Presbyterian Medical Center
- VA Medical Center
- New York Oncology Hematology, P.C., Riverview Cancer Care Medical Associates
- South Shore Hematology Oncology Associates, PC
- Raleigh Hematology Oncology Clinic
- Northwest Carolina Oncology and Hematology, P.A.
- Nashat Y. Gabrail, MD, Inc.
- University of Cincinnati, Barrett Cancer Center
- Columbus Community Clinical Oncology Program
- Dayton Oncology/Hematology Consultants
- University of Oklahoma Health Sciences Center
- Cancer Care Associates - Mercy Campus
- Cancer Care Associates
- Oncology/Hematology, Kaiser Permanente Northwest
- Oncology Hematology of Lehigh Valley, PC
- Medical Oncology Associates of Wyoming Valley, PC
- Charleston Hematology Oncology P.A.
- Liberty Hematology/Oncology
- WJB Dorn VA Medical Center
- Cancer Centers of the Carolinas
- Santee Hematology/Oncology
- Thompson Cancer Survival Center
- Boston Baskin Cancer Group
- Texas Oncology, P.A.
- South Austin Cancer Center
- Lone Star Oncology Consultants, P.A.
- Cancer Specialists of South Texas, PA
- Texas Cancer Center at Medical City
- Texas Oncology, P.A.
- Texas Oncology, P.A.
- Texas Oncology, P.A.
- University of Texas, MD Anderson Cancer Center
- Allison Cancer Center
- West Texas Cancer Center
- Hope Oncology
- Hematology & Oncology Associates of South Texas
- Tyler Cancer Center
- Texoma Cancer Center
- Utah Cancer Specialists
- Arlington Fairfax Hematology Oncology
- Hematology Oncology Patient Enterprises, Center for Cancer Care
- Danville Hematology & Oncology, Inc.
- Virginia Oncology Associates
- Stark MD, PC
- Virginia Cancer Institute
- Yakima Regional Cancer Care Center, Internal Medicine Associates of Yakima, Inc.
- Morgantown Internal Medicine Group
- Allgemeines offentliches Krankenhaus der barmherzigen Schwestern vom Heiligen Kreuz Pneumologie
- Sozialmedizinisches Zentrum
- Kaiser-Franz-Josef-Spital
- Algoma Regional Cancer Program - Sault Area Hospital
- Humber River Regional Hospital
- S.M.B.D. Jewish General Hospital
- Centre Hospitalier du Pays d'Aix
- Centre Hospitalier General de la Region Annecienne
- Centre Hospitalier d'Antibes-Juan-Les-Pins
- CHRU Hopital de Bois Guillaume
- DOP International
- Hopital de Draguignan
- Centre Hospitalier General
- Hopital du Cluzeau
- CHU Hopital St. Marguerite
- Centre Regional de Lutte contre le Cancer (CRLC), Val d'Aurelle-Paul Lamarque
- Hopital Saint Antoine
- CHU - Hopital Nord
- Hopital Saint Anne
- Service de Pneumology, Hopital Adulte de Brabois
- Centre Hospitalier
- Dept. of Internal Medicine, St. Nikolaus-Stiftshospital Andernach
- Aesklepios-Fachkliniken Muchen-Gauting
- Krankenhaus GroBhansdorf, Zentrum fur Pneumologie und Thoraxchirurgie
- Ludwig-Maximilians Universitat Munchen
- Charite Universitatsklinikum der Humboldt-Universitat zu Berlin
- Hospital Provincial de Castellon
- Hospital Clinico San Carlos
- Hospital Universitario Doctor Peset
- Hospital Universitario La Fe Servicio de Oncologia
- Hospital Arnau de Villanova, Servicio de Oncologia
- Hospital Clinico Universitario, Servicio Hematologia y Oncologia
- Hospital de Sagunto Servicio de Oncologia
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Experimental
Arm Label
bexarotene with carboplatin and paclitaxel
carboplatin and paclitaxel
Arm Description
Outcomes
Primary Outcome Measures
Overall Survival
Secondary Outcome Measures
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT00050960
Brief Title
Evaluation of Efficacy, Safety and Tolerability of Targretin Capsules in Patients With Advanced or Metastatic Non-small Cell Lung Cancer
Official Title
Randomized Phase III Trial Comparing Targretin Capsules/Carboplatin/Paclitaxel Versus Carboplatin/Paclitaxel in Chemotherapy-Naïve Patients With Advanced or Metastatic Non-Small Cell Lung Cancer
Study Type
Interventional
2. Study Status
Record Verification Date
July 2012
Overall Recruitment Status
Completed
Study Start Date
May 2002 (undefined)
Primary Completion Date
July 2004 (Actual)
Study Completion Date
March 2005 (Actual)
3. Sponsor/Collaborators
Name of the Sponsor
Eisai Inc.
4. Oversight
5. Study Description
Brief Summary
This study evaluates the use of Targretin capsules (bexarotene) in combination with standard chemotherapy for the treatment of metastatic Non-Small Cell Lung Cancer (NSCLC) in patients who have not yet received chemotherapy for their lung cancer.
Detailed Description
This study evaluates the use of Targretin capsules (bexarotene) in combination with Carboplatin and Paclitaxel for the treatment of metastatic non-small cell lung cancer in patients who have not yet received chemotherapy for their lung cancer. Every patient receives a platinum-containing chemotherapy every three weeks for at least four chemotherapy cycles (approximately four months). Half of the patients are randomly assigned to receive Targretin capsules once daily in addition to the chemotherapy. The other half is randomized to receive a standard platinum-containing chemotherapy without Targretin capsules.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Non-small Cell Lung Cancer
Keywords
NSCLC, Targretin, Retinoid, Bexarotene
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
612 (Actual)
8. Arms, Groups, and Interventions
Arm Title
bexarotene with carboplatin and paclitaxel
Arm Type
Experimental
Arm Title
carboplatin and paclitaxel
Arm Type
Experimental
Intervention Type
Drug
Intervention Name(s)
bexarotene with carboplatin and paclitaxel
Intervention Description
bexarotene capsules (400 mg/m^2/day) in combination with carboplatin IV (AUC 6) every 3 weeks and paclitaxel IV (200 mg/m^2) every 3 weeks. Subjects in this group also received an antilipid agent which was selected at the discretion of the investigator.
Intervention Type
Drug
Intervention Name(s)
carboplatin and paclitaxel
Intervention Description
carboplatin IV (AUC 6) every 3 weeks and paclitaxel IV (200 mg/m^2) every 3 weeks.
Primary Outcome Measure Information:
Title
Overall Survival
Time Frame
From date of randomization to date of death
10. Eligibility
Sex
All
Accepts Healthy Volunteers
No
Eligibility Criteria
Patients must have:
Pathologic (histologic or cytologic) confirmation of NSCLC
Stage IIIB with malignant pleural effusion or Stage IV disease
At least one measurable or evaluable NSCLC lesion that has not been previously irradiated unless radiation therapy was more than three weeks prior to entry in the study and the lesion has been shown to have progressed subsequent to the radiation therapy
ECOG performance status 0 or 1
Adequate organ system function
Fasting serum triglycerides that are within the age-adjusted normal range (or normalized with appropriate intervention such as antilipid therapy prior to the initiation of Targretin capsule therapy).
Patients must be able to complete at least four cycles of combination chemotherapy (i.e., approximately four months)
Patients must not have had:
Brain metastasis
Prior chemotherapy for NSCLC
Prior platinum-based chemotherapy for any indication
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Mack Mabry, M.D.
Organizational Affiliation
Ligand Pharmaceuticals
Official's Role
Study Director
Facility Information:
Facility Name
Montgomery Cancer Center, L.L.C.
City
Montgomery
State/Province
Alabama
ZIP/Postal Code
36106
Country
United States
Facility Name
Arizona Clinical Research Center, Inc.
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85712
Country
United States
Facility Name
Bay Area Cancer Research Group, LLC
City
Concord
State/Province
California
ZIP/Postal Code
94520
Country
United States
Facility Name
Compassionate Cancer Care Medical Group, Inc.
City
Fountain Valley
State/Province
California
ZIP/Postal Code
92708
Country
United States
Facility Name
Pacific Coast Hematology/Oncology Medical Group, Inc.
City
Fountain Valley
State/Province
California
ZIP/Postal Code
92708
Country
United States
Facility Name
California Cancer Care, Inc.
City
Greenbrae
State/Province
California
ZIP/Postal Code
94909
Country
United States
Facility Name
Coast Hematology and Oncology Associates
City
Long Beach
State/Province
California
ZIP/Postal Code
90806
Country
United States
Facility Name
Metropolitan Hematology/Oncology Medical Group
City
Los Angeles
State/Province
California
ZIP/Postal Code
90057
Country
United States
Facility Name
Sant P. Chawla, Inc.
City
Los Angeles
State/Province
California
ZIP/Postal Code
90067
Country
United States
Facility Name
UCLA Medical Center
City
Los Angeles
State/Province
California
ZIP/Postal Code
94115
Country
United States
Facility Name
Sutter Gould Medical Foundation
City
Modesto
State/Province
California
ZIP/Postal Code
95355
Country
United States
Facility Name
Medical Oncology Care Associates
City
Orange
State/Province
California
ZIP/Postal Code
92868
Country
United States
Facility Name
Southern California Kaiser Permanente Medical Group
City
San Diego
State/Province
California
ZIP/Postal Code
92120
Country
United States
Facility Name
Sharp Health Care
City
San Diego
State/Province
California
ZIP/Postal Code
92123
Country
United States
Facility Name
UCSF/Mount Zion Comprehensive Cancer Center
City
San Francisco
State/Province
California
ZIP/Postal Code
94115
Country
United States
Facility Name
Medical Group of North County, Inc., San Diego Cancer Center
City
Vista
State/Province
California
ZIP/Postal Code
92083
Country
United States
Facility Name
Rocky Mountain Cancer Centers - Midtown
City
Denver
State/Province
Colorado
ZIP/Postal Code
80218
Country
United States
Facility Name
Eastern Connecticut Hematology & Oncology
City
Norwich
State/Province
Connecticut
ZIP/Postal Code
06360
Country
United States
Facility Name
Georgetown University Hospital
City
Washington
State/Province
District of Columbia
ZIP/Postal Code
20007
Country
United States
Facility Name
Washington Cancer Institute
City
Washington
State/Province
District of Columbia
ZIP/Postal Code
20010
Country
United States
Facility Name
Comprehensive Cancer Care Specialists of Boca Raton
City
Boca Raton
State/Province
Florida
ZIP/Postal Code
33428
Country
United States
Facility Name
University of Florida/Jacksonville
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32209
Country
United States
Facility Name
Watson Clinic
City
Lakeland
State/Province
Florida
ZIP/Postal Code
33805
Country
United States
Facility Name
Oncology and Radiation Associates
City
Miami
State/Province
Florida
ZIP/Postal Code
33133
Country
United States
Facility Name
Florida Cancer Institute
City
New Port Richey
State/Province
Florida
ZIP/Postal Code
34652
Country
United States
Facility Name
Florida Oncology Associates
City
Orange Park
State/Province
Florida
ZIP/Postal Code
32073
Country
United States
Facility Name
Cancer Centers of Florida, P.A.
City
Orlando
State/Province
Florida
ZIP/Postal Code
32806
Country
United States
Facility Name
South Florida Oncology & Hematology Consultants
City
Plantation
State/Province
Florida
ZIP/Postal Code
33324
Country
United States
Facility Name
Medical Oncology Associates of Augusta
City
Augusta
State/Province
Georgia
ZIP/Postal Code
30901
Country
United States
Facility Name
Georgia Oncology Partners Research & Education Foundation
City
Marietta
State/Province
Georgia
ZIP/Postal Code
30060
Country
United States
Facility Name
St. Luke's/Mountain State Tumor Institute (MSTI)
City
Boise
State/Province
Idaho
ZIP/Postal Code
83712
Country
United States
Facility Name
Weiss Memorial Hospital
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60640
Country
United States
Facility Name
Northwest Oncology and Hematology, SC
City
Elk Grove Village
State/Province
Illinois
ZIP/Postal Code
60007
Country
United States
Facility Name
Lutheran General Cancer Care Center
City
Park Ridge
State/Province
Illinois
ZIP/Postal Code
60068
Country
United States
Facility Name
Oncology/Hematology Associates of Central Illinois, P.C.
City
Peoria
State/Province
Illinois
ZIP/Postal Code
61602
Country
United States
Facility Name
Hematology Oncology Assoc. of Illinois
City
Skokie
State/Province
Illinois
ZIP/Postal Code
60077
Country
United States
Facility Name
Central Indiana Cancer Centers
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46227
Country
United States
Facility Name
Cancer Care Center
City
New Albany
State/Province
Indiana
ZIP/Postal Code
47150
Country
United States
Facility Name
Michiana Hematology-Oncology
City
South Bend
State/Province
Indiana
ZIP/Postal Code
46601
Country
United States
Facility Name
Kansas City Oncology and Hematology Group, Kansas City Cancer Centers
City
Overland Park
State/Province
Kansas
ZIP/Postal Code
66210
Country
United States
Facility Name
Drs. Carroll, Sheth, and Raghavan
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40215
Country
United States
Facility Name
Southwest Oncology Associates
City
Lafayette
State/Province
Louisiana
ZIP/Postal Code
70503
Country
United States
Facility Name
APMC
City
Metairie
State/Province
Louisiana
ZIP/Postal Code
70006
Country
United States
Facility Name
Louisiana State University Health Sciences Center
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70112
Country
United States
Facility Name
Tulane University Health Sciences Center
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70112
Country
United States
Facility Name
Mercy Medical Center
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21202
Country
United States
Facility Name
Chesapeake Oncology-Hematology Associates
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21225
Country
United States
Facility Name
Associates in Oncology/Hematology PC
City
Rockville
State/Province
Maryland
ZIP/Postal Code
20850
Country
United States
Facility Name
Berkshire Hematology Oncology, PC
City
Pittsfield
State/Province
Massachusetts
ZIP/Postal Code
01201
Country
United States
Facility Name
University of Michigan Medical Center
City
Ann Arbor
State/Province
Michigan
ZIP/Postal Code
48109
Country
United States
Facility Name
Providence Cancer Institute
City
Southfield
State/Province
Michigan
ZIP/Postal Code
48075
Country
United States
Facility Name
St. Lukes Hospital
City
Duluth
State/Province
Minnesota
ZIP/Postal Code
55805
Country
United States
Facility Name
Minnesota Oncology Hematology, P.A.
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55407
Country
United States
Facility Name
Missouri Cancer Associates
City
Columbia
State/Province
Missouri
ZIP/Postal Code
65201
Country
United States
Facility Name
Hematology Oncology Centers of the Northern Rockies
City
Billings
State/Province
Montana
ZIP/Postal Code
59101
Country
United States
Facility Name
Montana Cancer & Infectious Disease Specialists
City
Missoula
State/Province
Montana
ZIP/Postal Code
59802
Country
United States
Facility Name
Cancer and Blood Specialists of Nevada
City
Henderson
State/Province
Nevada
ZIP/Postal Code
89014
Country
United States
Facility Name
Nevada Cancer Center
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89109
Country
United States
Facility Name
Dartmouth-Hitchcock Medical Center
City
Lebanon
State/Province
New Hampshire
ZIP/Postal Code
03756
Country
United States
Facility Name
Orange Medical Group
City
East Orange
State/Province
New Jersey
ZIP/Postal Code
07018
Country
United States
Facility Name
VA New Jersey Health Care System
City
East Orange
State/Province
New Jersey
ZIP/Postal Code
07018
Country
United States
Facility Name
Hematology-Oncology Associates of Northern NJ, PA
City
Morristown
State/Province
New Jersey
ZIP/Postal Code
07962
Country
United States
Facility Name
Somerset Hematology Oncology Associates
City
Somerset
State/Province
New Jersey
ZIP/Postal Code
08873
Country
United States
Facility Name
University of Medicine & Dentistry of NJ, School of Osteopathic Medicine
City
Stratford
State/Province
New Jersey
ZIP/Postal Code
08084
Country
United States
Facility Name
Overlook Oncology Center
City
Summit
State/Province
New Jersey
ZIP/Postal Code
07901
Country
United States
Facility Name
San Juan Oncology Associates
City
Farmington
State/Province
New Mexico
ZIP/Postal Code
87401
Country
United States
Facility Name
New York Oncology Hematology, P.C., Capital District Hematology Oncology Associates
City
Albany
State/Province
New York
ZIP/Postal Code
12208
Country
United States
Facility Name
Erie Medical Center
City
Buffalo
State/Province
New York
ZIP/Postal Code
14215
Country
United States
Facility Name
Roswell Park Cancer Institute
City
Buffalo
State/Province
New York
ZIP/Postal Code
14263
Country
United States
Facility Name
Arena Oncology Associates
City
Great Neck
State/Province
New York
ZIP/Postal Code
11021
Country
United States
Facility Name
Cancer Institute of Long Island, Inc.
City
Great Neck
State/Province
New York
ZIP/Postal Code
11023
Country
United States
Facility Name
Cancer Research of Long Island, Inc.
City
Great Neck
State/Province
New York
ZIP/Postal Code
11023
Country
United States
Facility Name
Broome Oncology, LLC
City
Johnson City
State/Province
New York
ZIP/Postal Code
13790
Country
United States
Facility Name
New York Presbyterian Hospital, Weill Medical College of Cornell University
City
New York
State/Province
New York
ZIP/Postal Code
10021
Country
United States
Facility Name
Columbia Presbyterian Medical Center
City
New York
State/Province
New York
ZIP/Postal Code
10032
Country
United States
Facility Name
VA Medical Center
City
Northport
State/Province
New York
ZIP/Postal Code
11768
Country
United States
Facility Name
New York Oncology Hematology, P.C., Riverview Cancer Care Medical Associates
City
Rexford
State/Province
New York
ZIP/Postal Code
12148
Country
United States
Facility Name
South Shore Hematology Oncology Associates, PC
City
Rockville Centre
State/Province
New York
ZIP/Postal Code
11570
Country
United States
Facility Name
Raleigh Hematology Oncology Clinic
City
Cary
State/Province
North Carolina
ZIP/Postal Code
27511
Country
United States
Facility Name
Northwest Carolina Oncology and Hematology, P.A.
City
Hickory
State/Province
North Carolina
ZIP/Postal Code
28602
Country
United States
Facility Name
Nashat Y. Gabrail, MD, Inc.
City
Canton
State/Province
Ohio
ZIP/Postal Code
44718
Country
United States
Facility Name
University of Cincinnati, Barrett Cancer Center
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45219
Country
United States
Facility Name
Columbus Community Clinical Oncology Program
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43206
Country
United States
Facility Name
Dayton Oncology/Hematology Consultants
City
Dayton
State/Province
Ohio
ZIP/Postal Code
45439
Country
United States
Facility Name
University of Oklahoma Health Sciences Center
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73104
Country
United States
Facility Name
Cancer Care Associates - Mercy Campus
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73120
Country
United States
Facility Name
Cancer Care Associates
City
Tulsa
State/Province
Oklahoma
ZIP/Postal Code
74136
Country
United States
Facility Name
Oncology/Hematology, Kaiser Permanente Northwest
City
Portland
State/Province
Oregon
ZIP/Postal Code
97227
Country
United States
Facility Name
Oncology Hematology of Lehigh Valley, PC
City
Bethlehem
State/Province
Pennsylvania
ZIP/Postal Code
18015
Country
United States
Facility Name
Medical Oncology Associates of Wyoming Valley, PC
City
Kingston
State/Province
Pennsylvania
ZIP/Postal Code
18704
Country
United States
Facility Name
Charleston Hematology Oncology P.A.
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29403
Country
United States
Facility Name
Liberty Hematology/Oncology
City
Columbia
State/Province
South Carolina
ZIP/Postal Code
29203
Country
United States
Facility Name
WJB Dorn VA Medical Center
City
Columbia
State/Province
South Carolina
ZIP/Postal Code
29209
Country
United States
Facility Name
Cancer Centers of the Carolinas
City
Seneca
State/Province
South Carolina
ZIP/Postal Code
29672
Country
United States
Facility Name
Santee Hematology/Oncology
City
Sumter
State/Province
South Carolina
ZIP/Postal Code
29150
Country
United States
Facility Name
Thompson Cancer Survival Center
City
Knoxville
State/Province
Tennessee
ZIP/Postal Code
37916
Country
United States
Facility Name
Boston Baskin Cancer Group
City
Memphis
State/Province
Tennessee
ZIP/Postal Code
38104
Country
United States
Facility Name
Texas Oncology, P.A.
City
Arlington
State/Province
Texas
ZIP/Postal Code
76012
Country
United States
Facility Name
South Austin Cancer Center
City
Austin
State/Province
Texas
ZIP/Postal Code
78745
Country
United States
Facility Name
Lone Star Oncology Consultants, P.A.
City
Austin
State/Province
Texas
ZIP/Postal Code
78759
Country
United States
Facility Name
Cancer Specialists of South Texas, PA
City
Corpus Christi
State/Province
Texas
ZIP/Postal Code
78412
Country
United States
Facility Name
Texas Cancer Center at Medical City
City
Dallas
State/Province
Texas
ZIP/Postal Code
75230
Country
United States
Facility Name
Texas Oncology, P.A.
City
Dallas
State/Province
Texas
ZIP/Postal Code
75246
Country
United States
Facility Name
Texas Oncology, P.A.
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76104
Country
United States
Facility Name
Texas Oncology, P.A.
City
Garland
State/Province
Texas
ZIP/Postal Code
75042
Country
United States
Facility Name
University of Texas, MD Anderson Cancer Center
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Allison Cancer Center
City
Midland
State/Province
Texas
ZIP/Postal Code
79701
Country
United States
Facility Name
West Texas Cancer Center
City
Odessa
State/Province
Texas
ZIP/Postal Code
79761
Country
United States
Facility Name
Hope Oncology
City
Richardson
State/Province
Texas
ZIP/Postal Code
75080
Country
United States
Facility Name
Hematology & Oncology Associates of South Texas
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229
Country
United States
Facility Name
Tyler Cancer Center
City
Tyler
State/Province
Texas
ZIP/Postal Code
75702
Country
United States
Facility Name
Texoma Cancer Center
City
Wichita Falls
State/Province
Texas
ZIP/Postal Code
76310
Country
United States
Facility Name
Utah Cancer Specialists
City
Salt Lake City
State/Province
Utah
ZIP/Postal Code
84106
Country
United States
Facility Name
Arlington Fairfax Hematology Oncology
City
Arlington
State/Province
Virginia
ZIP/Postal Code
22205
Country
United States
Facility Name
Hematology Oncology Patient Enterprises, Center for Cancer Care
City
Charlottesville
State/Province
Virginia
ZIP/Postal Code
22902
Country
United States
Facility Name
Danville Hematology & Oncology, Inc.
City
Danville
State/Province
Virginia
ZIP/Postal Code
24541
Country
United States
Facility Name
Virginia Oncology Associates
City
Norfolk
State/Province
Virginia
ZIP/Postal Code
23502
Country
United States
Facility Name
Stark MD, PC
City
Portsmouth
State/Province
Virginia
ZIP/Postal Code
23707
Country
United States
Facility Name
Virginia Cancer Institute
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23230
Country
United States
Facility Name
Yakima Regional Cancer Care Center, Internal Medicine Associates of Yakima, Inc.
City
Yakima
State/Province
Washington
ZIP/Postal Code
98902
Country
United States
Facility Name
Morgantown Internal Medicine Group
City
Morgantown
State/Province
West Virginia
ZIP/Postal Code
26505
Country
United States
Facility Name
Allgemeines offentliches Krankenhaus der barmherzigen Schwestern vom Heiligen Kreuz Pneumologie
City
Wels
ZIP/Postal Code
4600
Country
Austria
Facility Name
Sozialmedizinisches Zentrum
City
Wien
ZIP/Postal Code
1145
Country
Austria
Facility Name
Kaiser-Franz-Josef-Spital
City
Wien
ZIP/Postal Code
A-1100
Country
Austria
Facility Name
Algoma Regional Cancer Program - Sault Area Hospital
City
Sault Ste. Marie
State/Province
Ontario
ZIP/Postal Code
P6A 2C4
Country
Canada
Facility Name
Humber River Regional Hospital
City
Weston
State/Province
Ontario
ZIP/Postal Code
M9N 1N8
Country
Canada
Facility Name
S.M.B.D. Jewish General Hospital
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H3T 1E2
Country
Canada
Facility Name
Centre Hospitalier du Pays d'Aix
City
Aix en Provence, Cedex 01
ZIP/Postal Code
13616
Country
France
Facility Name
Centre Hospitalier General de la Region Annecienne
City
Annecy Cedex
ZIP/Postal Code
47011
Country
France
Facility Name
Centre Hospitalier d'Antibes-Juan-Les-Pins
City
Antibes Cedex
ZIP/Postal Code
06606
Country
France
Facility Name
CHRU Hopital de Bois Guillaume
City
Bois Guillaume
ZIP/Postal Code
76230
Country
France
Facility Name
DOP International
City
Creteil
ZIP/Postal Code
94010
Country
France
Facility Name
Hopital de Draguignan
City
Draguignan
ZIP/Postal Code
83300
Country
France
Facility Name
Centre Hospitalier General
City
Gap Cedex
ZIP/Postal Code
05007
Country
France
Facility Name
Hopital du Cluzeau
City
Limoges Cedex
ZIP/Postal Code
87042
Country
France
Facility Name
CHU Hopital St. Marguerite
City
Marseille, Cedex 09
ZIP/Postal Code
29274
Country
France
Facility Name
Centre Regional de Lutte contre le Cancer (CRLC), Val d'Aurelle-Paul Lamarque
City
Montpellier, Cedex 05
ZIP/Postal Code
34298
Country
France
Facility Name
Hopital Saint Antoine
City
Paris, Cedex 12
ZIP/Postal Code
75571
Country
France
Facility Name
CHU - Hopital Nord
City
St. Etienne, Cedex 2
ZIP/Postal Code
42055
Country
France
Facility Name
Hopital Saint Anne
City
Toulon Naval
ZIP/Postal Code
83800
Country
France
Facility Name
Service de Pneumology, Hopital Adulte de Brabois
City
Vandoeuvre les Nancy
ZIP/Postal Code
54511
Country
France
Facility Name
Centre Hospitalier
City
Villefranche sur Soane
ZIP/Postal Code
69655
Country
France
Facility Name
Dept. of Internal Medicine, St. Nikolaus-Stiftshospital Andernach
City
Andernach
ZIP/Postal Code
D-56626
Country
Germany
Facility Name
Aesklepios-Fachkliniken Muchen-Gauting
City
Gauting
ZIP/Postal Code
D-82131
Country
Germany
Facility Name
Krankenhaus GroBhansdorf, Zentrum fur Pneumologie und Thoraxchirurgie
City
GroBhansdorf
ZIP/Postal Code
22927
Country
Germany
Facility Name
Ludwig-Maximilians Universitat Munchen
City
Munchen
ZIP/Postal Code
80336
Country
Germany
Facility Name
Charite Universitatsklinikum der Humboldt-Universitat zu Berlin
City
SchumannstraBe, Berlin
ZIP/Postal Code
10117
Country
Germany
Facility Name
Hospital Provincial de Castellon
City
Castellon
ZIP/Postal Code
12002
Country
Spain
Facility Name
Hospital Clinico San Carlos
City
Madrid
ZIP/Postal Code
28040
Country
Spain
Facility Name
Hospital Universitario Doctor Peset
City
Valencia
ZIP/Postal Code
46 017
Country
Spain
Facility Name
Hospital Universitario La Fe Servicio de Oncologia
City
Valencia
ZIP/Postal Code
46018
Country
Spain
Facility Name
Hospital Arnau de Villanova, Servicio de Oncologia
City
Valencia
ZIP/Postal Code
46039
Country
Spain
Facility Name
Hospital Clinico Universitario, Servicio Hematologia y Oncologia
City
Valencia
ZIP/Postal Code
46044
Country
Spain
Facility Name
Hospital de Sagunto Servicio de Oncologia
City
Valencia
ZIP/Postal Code
46520
Country
Spain
12. IPD Sharing Statement
Links:
URL
http://www.Ligand.com
Description
Related Info
Learn more about this trial
Evaluation of Efficacy, Safety and Tolerability of Targretin Capsules in Patients With Advanced or Metastatic Non-small Cell Lung Cancer
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