Drug Treatment for Pathologic Gambling Disorder
Gambling
About this trial
This is an interventional treatment trial for Gambling focused on measuring Impulse Control Disorders
Eligibility Criteria
Inclusion Criteria: Diagnostic and Statistical Manual IV criteria for Pathological Gambling Disorder Moderate or severe gambling urge assessed by the Gambling Symptom Assessment Scale No psychiatric drug use for 2 weeks or more Score >= 5 on The South Oaks Gambling Screen Hamilton Depression Rating Scale and Anxiety Rating score < 26. An increase (up to 10 points) of the scores is allowed unless the subject shows the risks of suicide. Completion of complete blood count, urinalysis, liver and thyroid function tests, and pregnancy tests, with no evidence of significant lab abnormalities Reliable birth control in women of child-bearing potential
Sites / Locations
- University of Minnesota Medical School
Arms of the Study
Arm 1
Arm 2
Placebo Comparator
Placebo Comparator
Naltrexone
Placebo
17 weeks of double-blind Naltrexone. Subjects were randomized into one of these three conditions (if they weren't randomized to placebo): naltrexone 50mg/day, 100mg/day, 150mg/day. To minimize nausea, treatment for all subjects was initiated at 25mg/day naltrexone for two days, then the dose was increased to 50mg/day. At week 3, subjects were randomly assigned to 50mg/day continued at that dose, while subjects who were randomized to naltrexone 100mg/day or 150mg/day were raised to the higher doses.
Subjects who were assigned to placebo in the 17 week double-blind phase.