Back to resultsCombination Chemotherapy Followed By Radiation Therapy in Treating Patients With Aggressive Non-Hodgkin's Lymphoma
Primary Purpose
Lymphoma
Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
filgrastim
EPOCH regimen
cyclophosphamide
doxorubicin hydrochloride
etoposide
prednisone
vincristine sulfate
radiation therapy
Sponsored by
About this trial
This is an interventional treatment trial for Lymphoma focused on measuring contiguous stage II grade 3 follicular lymphoma, noncontiguous stage II grade 3 follicular lymphoma, stage I grade 3 follicular lymphoma, stage III grade 3 follicular lymphoma, stage IV grade 3 follicular lymphoma, contiguous stage II adult diffuse mixed cell lymphoma, noncontiguous stage II adult diffuse mixed cell lymphoma, stage I adult diffuse mixed cell lymphoma, stage III adult diffuse mixed cell lymphoma, stage IV adult diffuse mixed cell lymphoma, contiguous stage II adult diffuse large cell lymphoma, contiguous stage II adult Burkitt lymphoma, noncontiguous stage II adult diffuse large cell lymphoma, noncontiguous stage II adult Burkitt lymphoma, stage I adult diffuse large cell lymphoma, stage I adult Burkitt lymphoma, stage III adult diffuse large cell lymphoma, stage III adult Burkitt lymphoma, stage IV adult diffuse large cell lymphoma, stage IV adult Burkitt lymphoma, contiguous stage II adult immunoblastic large cell lymphoma, noncontiguous stage II adult immunoblastic large cell lymphoma, stage I adult immunoblastic large cell lymphoma, stage III adult immunoblastic large cell lymphoma, stage IV adult immunoblastic large cell lymphoma, contiguous stage II adult lymphoblastic lymphoma, noncontiguous stage II adult lymphoblastic lymphoma, stage I adult lymphoblastic lymphoma, stage III adult lymphoblastic lymphoma, stage IV adult lymphoblastic lymphoma, contiguous stage II mantle cell lymphoma, noncontiguous stage II mantle cell lymphoma, stage I mantle cell lymphoma, stage III mantle cell lymphoma, stage IV mantle cell lymphoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed aggressive non-Hodgkin's lymphoma Previously untreated disease Favorable prognosis International Prognostic Index score of 0-1 No more than 25% marrow involvement PATIENT CHARACTERISTICS: Age 18 to 60 Performance status ECOG 0-3 OR Karnofsky 40-100% Life expectancy Not specified Hematopoietic Platelet count at least 100,000/mm^3 WBC at least 2,500/mm^3 Hepatic No active hepatitis infection Renal Not specified Other HIV negative Not pregnant or nursing No relevant accompanying disease No other concurrent malignancy No contraindications to any study medications No prior noncompliance by patient PRIOR CONCURRENT THERAPY: Biologic therapy Not specified Chemotherapy No prior chemotherapy Endocrine therapy Not specified Radiotherapy No prior radiotherapy Surgery Not specified Other No other concurrent participation in another treatment study
Sites / Locations
- Haematologisch Onkologische Praxis
- Klinikum St. Marien
- Gemeinschaftspraxis Fuer Innere Medizin, Haematologie Und Internistische Onkologie
- Specialist Practice for Oncology
- II. Medizinische Klinik
- Haematologische Praxis
- Hamatologische/Onkologische Gemeinschaftspraxis - Augsburg
- Klinikum Augsburg
- Kreiskrankenhaus Aurich
- Kreiskrankenhaus
- Humaine - Clinic
- Krankenhaus Hohe Warte Mediziniche Klinik
- Onkolog - Haematolog Schwerpunktpraxis
- Charite - Campus Charite Mitte
- Hospital Complex Bernburg
- Krankenhaus Bietigheim
- Saint Agnes Hospital
- Saint Josef Hospital
- Knappschaft Krankenhaus
- Medizinische Poliklinik
- Rheinische Friedrich-Wilhelms-Universitat
- DIAKO Ev. Diakonie Krankenhaus gGmbH
- Medizinische Klinik Am Lukas - Krankenhaus
- General Hospital
- Hospital Kuchwald Chemnitz
- Carl - Thiem - Klinkum Cottbus
- Klinikum Darmstadt
- Saint Johannes Hospital Dortmund
- Universitatsklinikum Carl Gustav Carus
- Florence-Nightingale-Krankenhause, Deaconess Kaiserswerth
- St. Johannes Hospital - Medical Klinik II
- Franz Hospital Dulmen
- Hans - Susemihl - Krankenhaus
- Klinikum Erfurt
- St. Antonius Hospital
- Universitaetsklinikum Essen
- Evangelisches Krankenhaus Essen-Werden
- Klinikum Frankfurt (Oder) GmbH
- Krankenhaus Nordwest
- Evang. Deaconess Hospital Freiburg
- Municipal Hospital Complex
- Robert - Koch Hospital
- Centre for Internal Medicine Gießen
- Klinik Fuer Innere Medizin, Hematology/Oncology, Ernst Moritz Armdt Universitaet
- Staedtisches Klinikum Guetersloh
- Universitaetsklinikum Göttingen
- St. Marien Hospital - Katholisches Krankenhaus Hagen gGmbH
- Allgemeines Krankenhaus Hagen
- Krankenhaus St. Elisabeth und St. Barbara
- Krankenhaus Martha-Maria Halle-Doelau gGmbH
- Universitaetsklinikum Halle
- Universitaetsklinikum Hamburg-Eppendorf
- Asklepios Klinik Nord Heidberg
- Allgemeines Krankenhaus Altona
- Haematologisch-Onkologische Praxis Altona
- Evangelische Krankenhaus Hamm
- Krankenhaus Siloah - Medizinische Klinik II
- Henriettenstiftung Krankenhaus
- Medizinische Hochschule Hannover
- Oncology Specialists Clinic
- Medizinische Universitaetsklinik und Poliklinik
- Thoraxklinik Heidelberg
- Regional Hospital Heidenheim
- Regional Hospital Am Plattenwald - Bad Friedrichhall
- Klinikum Herford
- Marienhospital at Ruhr University Bochum
- Privatklinik Dr. R. Schindlbeck GmbH & Co. KG
- Onkologische Schwerpunktpraxis
- Evang. Hospital
- Medical University Hospital Homburg
- Universitaetsklinikum des Saarlandes
- Hospital Complex Hoyerswerda
- Gemeinschaftspraxis Innere Medizin
- Klinikum der Friedrich-Schiller Universitaet Jena
- Municipal Hospital Complex of the University
- Staedtisches Klinikum Karlsruhe gGmbH
- Red Cross Hospital Kassel
- Staedtisches Krankenhaus Kiel
- Praxis fuer Haematologie und Onkologie
- Stiftungsklinikum Mittelrhein - Gesundheitszentrum Evangelisches Stift Sankt Martin Koblenz gGmbH
- Kliniken der Stadt Koeln gGmbH - Krankenhaus Merheim
- Praxis Fuer Haematologie Internistische Onkologie
- Medizinische Universitaetsklinik I at the University of Cologne
- Leonardis Clinic
- Klinikum Krefeld GmbH
- Frankenwald Klinik
- Caritas - Krakenhaus Lebach
- Medizinische Klinik und Poliklinik III - Universitaetsklinikum Leipzig
- University Leipzig Clinic of Internal Medicine
- Staedtisches Klinikum "St. Georg" Leipzig
- Klinikum Lippe - Lemgo
- St. Vincenz Hospital Limburg
- St. Bonifatius Hospital Lingen
- Dreifaltigkeits Hospital
- Klinikum Ludwigsburg
- Klinikum der Stadt Ludwigshafen am Rhein
- St. Marien Hospital Ludwighafen
- Universitaetsklinikum Schleswig-Holstein - Campus Luebeck
- Staedtisches Klinikum Magdeburg - Altstadt
- Universitaetsklinkum Magdeburg der Otto-von-Guericke-Universitaet Magdeburg
- Johannes Gutenberg University
- German CML Study Group
- Philipps-Universitaet Marburg Klinikum
- Regional Hospital Mayen
- Klinikum Minden
- Ev. Hospital Bethesda
- Hospital Maria-Hilf II
- St. Marien Hospital - Muelheim an der Ruhr
- Kreiskrankenhaus Muenchberg
- Munich Oncologic Practice at Elisenhof
- Klinikum der Universitaet Muenchen - Innenstadt Campus
- Krankenhaus Muenchen Schwabing
- Klinikum der Universitaet Muenchen - Grosshadern Campus
- Medizinische Klinik und Poliklinik A - Universitaetsklinikum Muenster
- Evangelisches Krankenhaus - Mülheim
- Regional Hospital Neumarkt
- Staedtisches Klinikum Neunkirchen gGmbH
- Lukaskrankenhaus Neuss
- Klinikum Nuernberg - Klinikum Nord
- Klinikum Offenburg
- Hematologische Praxis
- Ev. Hospital Oldenburg
- Klinikum Oldenburg
- Paracelsus - Klinik Osnabrück
- Municipal Hospital Complex
- Klinikum Ernst Von Bergmann
- Kreiskrankenhaus Radebeul
- Krankenhaus St. Elisabeth - Ravensburg
- Klinikum der Universitaet Regensburg
- Hematologische Onkologische Praxis
- Krankenhaus Barmherzige Brueder Regensburg
- Jakobi Krankenhaus
- Klinik und Poliklinik fuer Innere Medizin - Universitaet Rostock
- Klinik und Poliklinik fuer Strahlentherapie - Universitaetsklinikum Rostock
- Caritasklinik St. Theresia
- Schwerpunktpraxis fuer Haematologie und Onkologie
- St. Elizabeth-Klinik Saarlouis
- Martin - Luther Hospital
- Deaconess Hospital
- Leopoldina - Krankenhaus
- Evang. Jung-Stilling Hospital
- St. Lukas - Clinic Solingen
- Klinik fuer Onkologie - Katharinenhospital Stuttgart
- Diakonie Klinikum Stuttgart
- Klinikum Stuttgart - Buergerhospital
- Hospital Bad Cannstatt
- Robert-Bosch-Krankenhaus
- St. Elisabeth Hospital Thuine
- Regional Hospital Traunstein
- Krankenanstalt Mutterhaus der Borromaerinnen
- Krankenhaus Der Barmherzigen Brueder
- Hospital Tutzing
- Comprehensive Cancer Center Ulm at Universitaetsklinikum Ulm
- Ev. Hospital Unna
- St. Marienhospital - Vechta
- Klinikum Der Stadt Villingen - Schwenningen
- Regional Hospital Waldbrol
- Hospital Wetzler
- Deutsche Klinik fuer Diagnostik
- Dr. Horst-Schmidt-Kliniken
- Ev. Hospital Witten-Herdecke
- University Wurzburg
- Kliniken St. Antonius
- Municipal Hospital Complex Zwickau
- UniversitaetsSpital Zuerich
- City Hospital Triemli
Arms of the Study
Arm 1
Arm 2
Arm Type
Active Comparator
Experimental
Arm Label
CHOEP-21
high CHOEP-21
Arm Description
CHOEP-21-Schema: Cyclophosphamid (750 mg/m2 i.v. d1), Doxorubicin (50 mg/m2 i.v. d1), Vincristin (2 mg i.v. d1), Etoposid (100 mg/m² i.v. d1-3), Prednison (100 mg p.o. d1-5)
High-CHOEP-21-Schema: Cyclophosphamid (1400 mg/m2 i.v. d1), Doxorubicin (32,5 mg/m2 i.v. d1+2), Vincristin (2 mg i.v. d1), Etoposid (175 mg/m² i.v. d1-3), Prednison (100 mg p.o. d1-5)
Outcomes
Primary Outcome Measures
Time to treatment failure (TTF) at first relapse
Time to Treatment failure using the Kaplan_Meier-Method
Secondary Outcome Measures
Complete response rate at first relapse
Number of complete remission (CR) and unconfirmed complete Remission (CRu)
Survival time
Time till death (whatever cause)
Tumor control
Calcution of treatment Duration using the Kaplan-Meier method
Disease-free survival
Time of disease-free survivial
Full Information
NCT ID
NCT00053768
First Posted
February 5, 2003
Last Updated
May 14, 2021
Sponsor
German High-Grade Non-Hodgkin's Lymphoma Study Group
1. Study Identification
Unique Protocol Identification Number
NCT00053768
Brief Title
Combination Chemotherapy Followed By Radiation Therapy in Treating Patients With Aggressive Non-Hodgkin's Lymphoma
Official Title
Randomised Trial Comparing Chemotherapy Mit CHOEP (Cyclophosphamid, Doxorubicin, Vincristin, Etoposid Und Prednison) In 21-Day Intervals In Standard And Escalated Doses In Patients Aged 18-60 Years Of Age With Aggresive Non-Hodgkin-Lymphomas Favourable Prognoses
Study Type
Interventional
2. Study Status
Record Verification Date
May 2021
Overall Recruitment Status
Completed
Study Start Date
April 2002 (undefined)
Primary Completion Date
December 5, 2006 (Actual)
Study Completion Date
December 5, 2006 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
German High-Grade Non-Hodgkin's Lymphoma Study Group
4. Oversight
5. Study Description
Brief Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug and giving the drugs in different ways may kill more cancer cells. Radiation therapy uses high-energy x-rays to damage cancer cells. It is not yet known which combination chemotherapy regimen followed by radiation therapy is more effective in treating aggressive non-Hodgkin's lymphoma.
PURPOSE: This randomized phase III trial is studying two combination chemotherapy regimens followed by radiation therapy to compare how well they work in treating patients with aggressive non-Hodgkin's lymphoma.
Detailed Description
OBJECTIVES:
Compare the efficacy of standard-dose vs high-dose cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone followed by radiotherapy, in terms of time to treatment failure, in patients with aggressive non-Hodgkin's lymphoma.
Compare the acute and long-term toxic effects of these regimens in these patients.
Compare the complete response rate, survival and tumor control, and disease-free survival in patients treated with these regimens.
Analyze the time to relapse after radiotherapy in these patients.
OUTLINE: This is a randomized, open-label, multicenter study. Patients are stratified according to LDH levels (no greater than upper limit of normal [ULN] vs greater than ULN), initial bulky disease (yes vs no), stage (I or II vs II or IV), ECOG performance status (0 or 1 vs 2 or 3), and participating center. Patients are randomized to 1 of 2 treatment arms as follows:
Arm I (Standard dose): Patients receive cyclophosphamide IV, doxorubicin IV, and vincristine IV on day 1; etoposide IV on days 1-3; and oral prednisone on days 1-5 (CHOEP) in standard doses.
Arm II (Escalated dose): Patients receive high-dose CHOEP as in arm I. Patients also receive filgrastim (G-CSF) subcutaneously on days 6-12.
In both arms, treatment repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity.
After completion of CHOEP chemotherapy, patients with initial bulky disease or extranodal involvement undergo radiotherapy 5 days a week for 4 weeks.
Patients who undergo radiotherapy are followed at 2 months after radiotherapy. All patients (including those who undergo radiotherapy) are followed every 3 months for 2 years and then every 6 months for 3 years.
PROJECTED ACCRUAL: A total of 389 patients were accrued for this study.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Lymphoma
Keywords
contiguous stage II grade 3 follicular lymphoma, noncontiguous stage II grade 3 follicular lymphoma, stage I grade 3 follicular lymphoma, stage III grade 3 follicular lymphoma, stage IV grade 3 follicular lymphoma, contiguous stage II adult diffuse mixed cell lymphoma, noncontiguous stage II adult diffuse mixed cell lymphoma, stage I adult diffuse mixed cell lymphoma, stage III adult diffuse mixed cell lymphoma, stage IV adult diffuse mixed cell lymphoma, contiguous stage II adult diffuse large cell lymphoma, contiguous stage II adult Burkitt lymphoma, noncontiguous stage II adult diffuse large cell lymphoma, noncontiguous stage II adult Burkitt lymphoma, stage I adult diffuse large cell lymphoma, stage I adult Burkitt lymphoma, stage III adult diffuse large cell lymphoma, stage III adult Burkitt lymphoma, stage IV adult diffuse large cell lymphoma, stage IV adult Burkitt lymphoma, contiguous stage II adult immunoblastic large cell lymphoma, noncontiguous stage II adult immunoblastic large cell lymphoma, stage I adult immunoblastic large cell lymphoma, stage III adult immunoblastic large cell lymphoma, stage IV adult immunoblastic large cell lymphoma, contiguous stage II adult lymphoblastic lymphoma, noncontiguous stage II adult lymphoblastic lymphoma, stage I adult lymphoblastic lymphoma, stage III adult lymphoblastic lymphoma, stage IV adult lymphoblastic lymphoma, contiguous stage II mantle cell lymphoma, noncontiguous stage II mantle cell lymphoma, stage I mantle cell lymphoma, stage III mantle cell lymphoma, stage IV mantle cell lymphoma
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
392 (Actual)
8. Arms, Groups, and Interventions
Arm Title
CHOEP-21
Arm Type
Active Comparator
Arm Description
CHOEP-21-Schema:
Cyclophosphamid (750 mg/m2 i.v. d1), Doxorubicin (50 mg/m2 i.v. d1), Vincristin (2 mg i.v. d1), Etoposid (100 mg/m² i.v. d1-3), Prednison (100 mg p.o. d1-5)
Arm Title
high CHOEP-21
Arm Type
Experimental
Arm Description
High-CHOEP-21-Schema:
Cyclophosphamid (1400 mg/m2 i.v. d1), Doxorubicin (32,5 mg/m2 i.v. d1+2), Vincristin (2 mg i.v. d1), Etoposid (175 mg/m² i.v. d1-3), Prednison (100 mg p.o. d1-5)
Intervention Type
Biological
Intervention Name(s)
filgrastim
Intervention Type
Drug
Intervention Name(s)
EPOCH regimen
Intervention Type
Drug
Intervention Name(s)
cyclophosphamide
Intervention Type
Drug
Intervention Name(s)
doxorubicin hydrochloride
Intervention Type
Drug
Intervention Name(s)
etoposide
Intervention Type
Drug
Intervention Name(s)
prednisone
Intervention Type
Drug
Intervention Name(s)
vincristine sulfate
Intervention Type
Radiation
Intervention Name(s)
radiation therapy
Primary Outcome Measure Information:
Title
Time to treatment failure (TTF) at first relapse
Description
Time to Treatment failure using the Kaplan_Meier-Method
Time Frame
3 years within study and periodically after study completion
Secondary Outcome Measure Information:
Title
Complete response rate at first relapse
Description
Number of complete remission (CR) and unconfirmed complete Remission (CRu)
Time Frame
3 years within study and periodically after study completion
Title
Survival time
Description
Time till death (whatever cause)
Time Frame
3 years within study and periodically after study completion
Title
Tumor control
Description
Calcution of treatment Duration using the Kaplan-Meier method
Time Frame
thought the treatment
Title
Disease-free survival
Description
Time of disease-free survivial
Time Frame
3 years within study and periodically after study completion
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
60 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
DISEASE CHARACTERISTICS:
Histologically confirmed aggressive non-Hodgkin's lymphoma
Previously untreated disease
Favorable prognosis
International Prognostic Index score of 0-1
No more than 25% marrow involvement
PATIENT CHARACTERISTICS:
Age
18 to 60
Performance status
ECOG 0-3 OR
Karnofsky 40-100%
Life expectancy
Not specified
Hematopoietic
Platelet count at least 100,000/mm^3
WBC at least 2,500/mm^3
Hepatic
No active hepatitis infection
Renal
Not specified
Other
HIV negative
Not pregnant or nursing
No relevant accompanying disease
No other concurrent malignancy
No contraindications to any study medications
No prior noncompliance by patient
PRIOR CONCURRENT THERAPY:
Biologic therapy
Not specified
Chemotherapy
No prior chemotherapy
Endocrine therapy
Not specified
Radiotherapy
No prior radiotherapy
Surgery
Not specified
Other
No other concurrent participation in another treatment study
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Michael G.M. Pfreundschuh, MD
Organizational Affiliation
Universitaetsklinikum des Saarlandes
Official's Role
Study Chair
Facility Information:
Facility Name
Haematologisch Onkologische Praxis
City
Aachen
ZIP/Postal Code
52070
Country
Germany
Facility Name
Klinikum St. Marien
City
Amberg
ZIP/Postal Code
D-92224
Country
Germany
Facility Name
Gemeinschaftspraxis Fuer Innere Medizin, Haematologie Und Internistische Onkologie
City
Ansbach
ZIP/Postal Code
D-91522
Country
Germany
Facility Name
Specialist Practice for Oncology
City
Aschaffenburg
ZIP/Postal Code
63739
Country
Germany
Facility Name
II. Medizinische Klinik
City
Aschaffenburg
ZIP/Postal Code
D-63739
Country
Germany
Facility Name
Haematologische Praxis
City
Augsburg
ZIP/Postal Code
86150
Country
Germany
Facility Name
Hamatologische/Onkologische Gemeinschaftspraxis - Augsburg
City
Augsburg
ZIP/Postal Code
86150
Country
Germany
Facility Name
Klinikum Augsburg
City
Augsburg
ZIP/Postal Code
D-86156
Country
Germany
Facility Name
Kreiskrankenhaus Aurich
City
Aurich
ZIP/Postal Code
D-26603
Country
Germany
Facility Name
Kreiskrankenhaus
City
Bad Hersfeld
ZIP/Postal Code
D-36251
Country
Germany
Facility Name
Humaine - Clinic
City
Bad Saarow
ZIP/Postal Code
D-15526
Country
Germany
Facility Name
Krankenhaus Hohe Warte Mediziniche Klinik
City
Bayreuth
ZIP/Postal Code
D-95445
Country
Germany
Facility Name
Onkolog - Haematolog Schwerpunktpraxis
City
Berlin
ZIP/Postal Code
13357
Country
Germany
Facility Name
Charite - Campus Charite Mitte
City
Berlin
ZIP/Postal Code
D-13125
Country
Germany
Facility Name
Hospital Complex Bernburg
City
Bernburg
ZIP/Postal Code
D-06406
Country
Germany
Facility Name
Krankenhaus Bietigheim
City
Bietigheim
ZIP/Postal Code
D-74319
Country
Germany
Facility Name
Saint Agnes Hospital
City
Bocholt
ZIP/Postal Code
D-46397
Country
Germany
Facility Name
Saint Josef Hospital
City
Bochum
ZIP/Postal Code
D-44791
Country
Germany
Facility Name
Knappschaft Krankenhaus
City
Bochum
ZIP/Postal Code
D-44892
Country
Germany
Facility Name
Medizinische Poliklinik
City
Bonn
ZIP/Postal Code
D-53111
Country
Germany
Facility Name
Rheinische Friedrich-Wilhelms-Universitat
City
Bonn
ZIP/Postal Code
D-53113
Country
Germany
Facility Name
DIAKO Ev. Diakonie Krankenhaus gGmbH
City
Bremen
ZIP/Postal Code
D-28239
Country
Germany
Facility Name
Medizinische Klinik Am Lukas - Krankenhaus
City
Bunde
ZIP/Postal Code
D-32257
Country
Germany
Facility Name
General Hospital
City
Celle
ZIP/Postal Code
D-29223
Country
Germany
Facility Name
Hospital Kuchwald Chemnitz
City
Chemnitz
ZIP/Postal Code
D-09113
Country
Germany
City
Cologne-Kalk
ZIP/Postal Code
D-51105
Country
Germany
Facility Name
Carl - Thiem - Klinkum Cottbus
City
Cottbus
ZIP/Postal Code
D-03048
Country
Germany
Facility Name
Klinikum Darmstadt
City
Darmstadt
ZIP/Postal Code
D-64283
Country
Germany
Facility Name
Saint Johannes Hospital Dortmund
City
Dortmund
ZIP/Postal Code
D-44137
Country
Germany
Facility Name
Universitatsklinikum Carl Gustav Carus
City
Dresden
ZIP/Postal Code
D-01307
Country
Germany
Facility Name
Florence-Nightingale-Krankenhause, Deaconess Kaiserswerth
City
Duesseldorf
ZIP/Postal Code
D-40489
Country
Germany
Facility Name
St. Johannes Hospital - Medical Klinik II
City
Duisburg
ZIP/Postal Code
D-47166
Country
Germany
Facility Name
Franz Hospital Dulmen
City
Dulmen
ZIP/Postal Code
D-48249
Country
Germany
Facility Name
Hans - Susemihl - Krankenhaus
City
Emden
ZIP/Postal Code
D-26721
Country
Germany
Facility Name
Klinikum Erfurt
City
Erfurt
ZIP/Postal Code
99089
Country
Germany
Facility Name
St. Antonius Hospital
City
Eschweiler
ZIP/Postal Code
52249
Country
Germany
Facility Name
Universitaetsklinikum Essen
City
Essen
ZIP/Postal Code
D-45147
Country
Germany
Facility Name
Evangelisches Krankenhaus Essen-Werden
City
Essen
ZIP/Postal Code
D-45239
Country
Germany
Facility Name
Klinikum Frankfurt (Oder) GmbH
City
Frankfurt/Oder
ZIP/Postal Code
15236
Country
Germany
Facility Name
Krankenhaus Nordwest
City
Frankfurt
ZIP/Postal Code
60488
Country
Germany
Facility Name
Evang. Deaconess Hospital Freiburg
City
Freiburg
ZIP/Postal Code
D-79110
Country
Germany
Facility Name
Municipal Hospital Complex
City
Fulda
ZIP/Postal Code
36043
Country
Germany
Facility Name
Robert - Koch Hospital
City
Gehrden
ZIP/Postal Code
30989
Country
Germany
Facility Name
Centre for Internal Medicine Gießen
City
Gießen
ZIP/Postal Code
D-35392
Country
Germany
Facility Name
Klinik Fuer Innere Medizin, Hematology/Oncology, Ernst Moritz Armdt Universitaet
City
Greifswald
ZIP/Postal Code
D-17489
Country
Germany
Facility Name
Staedtisches Klinikum Guetersloh
City
Gutersloh
ZIP/Postal Code
33332
Country
Germany
Facility Name
Universitaetsklinikum Göttingen
City
Göttingen
ZIP/Postal Code
D-37075
Country
Germany
Facility Name
St. Marien Hospital - Katholisches Krankenhaus Hagen gGmbH
City
Hagen
ZIP/Postal Code
58095
Country
Germany
Facility Name
Allgemeines Krankenhaus Hagen
City
Hagen
ZIP/Postal Code
D-58095
Country
Germany
Facility Name
Krankenhaus St. Elisabeth und St. Barbara
City
Halle/Saale
ZIP/Postal Code
06110
Country
Germany
Facility Name
Krankenhaus Martha-Maria Halle-Doelau gGmbH
City
Halle
ZIP/Postal Code
06120
Country
Germany
Facility Name
Universitaetsklinikum Halle
City
Halle
ZIP/Postal Code
D-06097
Country
Germany
City
Hamburg
ZIP/Postal Code
20095
Country
Germany
Facility Name
Universitaetsklinikum Hamburg-Eppendorf
City
Hamburg
ZIP/Postal Code
D-20251
Country
Germany
Facility Name
Asklepios Klinik Nord Heidberg
City
Hamburg
ZIP/Postal Code
D-22413
Country
Germany
Facility Name
Allgemeines Krankenhaus Altona
City
Hamburg
ZIP/Postal Code
D-22763
Country
Germany
Facility Name
Haematologisch-Onkologische Praxis Altona
City
Hamburg
ZIP/Postal Code
D-22767
Country
Germany
Facility Name
Evangelische Krankenhaus Hamm
City
Hamm
ZIP/Postal Code
D-59063
Country
Germany
City
Hannover
ZIP/Postal Code
30159
Country
Germany
Facility Name
Krankenhaus Siloah - Medizinische Klinik II
City
Hannover
ZIP/Postal Code
30449
Country
Germany
Facility Name
Henriettenstiftung Krankenhaus
City
Hannover
ZIP/Postal Code
30559
Country
Germany
Facility Name
Medizinische Hochschule Hannover
City
Hannover
ZIP/Postal Code
30625
Country
Germany
Facility Name
Oncology Specialists Clinic
City
Harrislee
ZIP/Postal Code
D-24955
Country
Germany
Facility Name
Medizinische Universitaetsklinik und Poliklinik
City
Heidelberg
ZIP/Postal Code
69115
Country
Germany
Facility Name
Thoraxklinik Heidelberg
City
Heidelberg
ZIP/Postal Code
D-69126
Country
Germany
Facility Name
Regional Hospital Heidenheim
City
Heidenheim
ZIP/Postal Code
89522
Country
Germany
Facility Name
Regional Hospital Am Plattenwald - Bad Friedrichhall
City
Heilbronn
ZIP/Postal Code
D-74172
Country
Germany
Facility Name
Klinikum Herford
City
Herford
ZIP/Postal Code
32049
Country
Germany
Facility Name
Marienhospital at Ruhr University Bochum
City
Herne
ZIP/Postal Code
44625
Country
Germany
Facility Name
Privatklinik Dr. R. Schindlbeck GmbH & Co. KG
City
Herrsching Am Ammersee
ZIP/Postal Code
D-82211
Country
Germany
Facility Name
Onkologische Schwerpunktpraxis
City
Hildesheim
ZIP/Postal Code
31134
Country
Germany
Facility Name
Evang. Hospital
City
Holzminden
ZIP/Postal Code
D-37603
Country
Germany
Facility Name
Medical University Hospital Homburg
City
Homburg
ZIP/Postal Code
66421
Country
Germany
Facility Name
Universitaetsklinikum des Saarlandes
City
Homburg
ZIP/Postal Code
D-66424
Country
Germany
Facility Name
Hospital Complex Hoyerswerda
City
Hoyerswerda
ZIP/Postal Code
D-02977
Country
Germany
Facility Name
Gemeinschaftspraxis Innere Medizin
City
Jena
ZIP/Postal Code
D-07743
Country
Germany
Facility Name
Klinikum der Friedrich-Schiller Universitaet Jena
City
Jena
ZIP/Postal Code
D-07747
Country
Germany
Facility Name
Municipal Hospital Complex of the University
City
Kaiserslautern
ZIP/Postal Code
D-67655
Country
Germany
Facility Name
Staedtisches Klinikum Karlsruhe gGmbH
City
Karlsruhe
ZIP/Postal Code
D-76133
Country
Germany
Facility Name
Red Cross Hospital Kassel
City
Kassel
ZIP/Postal Code
D-34121
Country
Germany
Facility Name
Staedtisches Krankenhaus Kiel
City
Kiel
ZIP/Postal Code
D-23116
Country
Germany
Facility Name
Praxis fuer Haematologie und Onkologie
City
Koblenz
ZIP/Postal Code
D-56068
Country
Germany
Facility Name
Stiftungsklinikum Mittelrhein - Gesundheitszentrum Evangelisches Stift Sankt Martin Koblenz gGmbH
City
Koblenz
ZIP/Postal Code
D-56068
Country
Germany
Facility Name
Kliniken der Stadt Koeln gGmbH - Krankenhaus Merheim
City
Koln-Merheim
ZIP/Postal Code
D-51109
Country
Germany
Facility Name
Praxis Fuer Haematologie Internistische Onkologie
City
Koln
ZIP/Postal Code
D-50677
Country
Germany
Facility Name
Medizinische Universitaetsklinik I at the University of Cologne
City
Koln
ZIP/Postal Code
D-50924
Country
Germany
Facility Name
Leonardis Clinic
City
Kornwestheim
ZIP/Postal Code
D-70806
Country
Germany
Facility Name
Klinikum Krefeld GmbH
City
Krefeld
ZIP/Postal Code
D-47805
Country
Germany
Facility Name
Frankenwald Klinik
City
Kronach
ZIP/Postal Code
D-96317
Country
Germany
Facility Name
Caritas - Krakenhaus Lebach
City
Lebach
ZIP/Postal Code
D-66822
Country
Germany
Facility Name
Medizinische Klinik und Poliklinik III - Universitaetsklinikum Leipzig
City
Leipzig
ZIP/Postal Code
D-04103
Country
Germany
Facility Name
University Leipzig Clinic of Internal Medicine
City
Leipzig
ZIP/Postal Code
D-04103
Country
Germany
City
Leipzig
ZIP/Postal Code
D-04103
Country
Germany
Facility Name
Staedtisches Klinikum "St. Georg" Leipzig
City
Leipzig
ZIP/Postal Code
D-04129
Country
Germany
Facility Name
Klinikum Lippe - Lemgo
City
Lemgo
ZIP/Postal Code
D-32657
Country
Germany
Facility Name
St. Vincenz Hospital Limburg
City
Limburg
ZIP/Postal Code
D-65549
Country
Germany
Facility Name
St. Bonifatius Hospital Lingen
City
Lingen
ZIP/Postal Code
D-49808
Country
Germany
Facility Name
Dreifaltigkeits Hospital
City
Lippstadt
ZIP/Postal Code
D-59555
Country
Germany
Facility Name
Klinikum Ludwigsburg
City
Ludwigsburg
ZIP/Postal Code
D-71460
Country
Germany
Facility Name
Klinikum der Stadt Ludwigshafen am Rhein
City
Ludwigshafen
ZIP/Postal Code
D-67063
Country
Germany
Facility Name
St. Marien Hospital Ludwighafen
City
Ludwigshafen
ZIP/Postal Code
D-67067
Country
Germany
Facility Name
Universitaetsklinikum Schleswig-Holstein - Campus Luebeck
City
Luebeck
ZIP/Postal Code
D-23538
Country
Germany
Facility Name
Staedtisches Klinikum Magdeburg - Altstadt
City
Magdeburg
ZIP/Postal Code
D-39104
Country
Germany
Facility Name
Universitaetsklinkum Magdeburg der Otto-von-Guericke-Universitaet Magdeburg
City
Magdeburg
ZIP/Postal Code
D-39120
Country
Germany
Facility Name
Johannes Gutenberg University
City
Mainz
ZIP/Postal Code
D-55131
Country
Germany
Facility Name
German CML Study Group
City
Manheim
ZIP/Postal Code
D-68305
Country
Germany
City
Marburg
ZIP/Postal Code
D-35037
Country
Germany
Facility Name
Philipps-Universitaet Marburg Klinikum
City
Marburg
ZIP/Postal Code
D-35043
Country
Germany
Facility Name
Regional Hospital Mayen
City
Mayen
ZIP/Postal Code
D-56727
Country
Germany
Facility Name
Klinikum Minden
City
Minden
ZIP/Postal Code
D-32423
Country
Germany
City
Minden
ZIP/Postal Code
D-32427
Country
Germany
Facility Name
Ev. Hospital Bethesda
City
Monchenglabach
ZIP/Postal Code
D-41061
Country
Germany
Facility Name
Hospital Maria-Hilf II
City
Monchengladbach
ZIP/Postal Code
D-41063
Country
Germany
City
Monchenglasbach/Rheydt
ZIP/Postal Code
D-41239
Country
Germany
Facility Name
St. Marien Hospital - Muelheim an der Ruhr
City
Mulheim/Ruhr
ZIP/Postal Code
D-45468
Country
Germany
Facility Name
Kreiskrankenhaus Muenchberg
City
Munchberg
ZIP/Postal Code
D-95213
Country
Germany
Facility Name
Munich Oncologic Practice at Elisenhof
City
Munchen
ZIP/Postal Code
D-80335
Country
Germany
Facility Name
Klinikum der Universitaet Muenchen - Innenstadt Campus
City
Munchen
ZIP/Postal Code
D-80336
Country
Germany
Facility Name
Krankenhaus Muenchen Schwabing
City
Munich
ZIP/Postal Code
D-80804
Country
Germany
Facility Name
Klinikum der Universitaet Muenchen - Grosshadern Campus
City
Munich
ZIP/Postal Code
D-81377
Country
Germany
Facility Name
Medizinische Klinik und Poliklinik A - Universitaetsklinikum Muenster
City
Munster
ZIP/Postal Code
D-48129
Country
Germany
Facility Name
Evangelisches Krankenhaus - Mülheim
City
Mülheim
ZIP/Postal Code
D-45466
Country
Germany
Facility Name
Regional Hospital Neumarkt
City
Neumarkt
ZIP/Postal Code
D-92318
Country
Germany
Facility Name
Staedtisches Klinikum Neunkirchen gGmbH
City
Neunkirchen
ZIP/Postal Code
D-66538
Country
Germany
Facility Name
Lukaskrankenhaus Neuss
City
Neuss
ZIP/Postal Code
D-41464
Country
Germany
Facility Name
Klinikum Nuernberg - Klinikum Nord
City
Nurnberg
ZIP/Postal Code
D-90340
Country
Germany
Facility Name
Klinikum Offenburg
City
Offenburg
ZIP/Postal Code
D-77654
Country
Germany
Facility Name
Hematologische Praxis
City
Oldenburg
ZIP/Postal Code
D-26121
Country
Germany
Facility Name
Ev. Hospital Oldenburg
City
Oldenburg
ZIP/Postal Code
D-26122
Country
Germany
Facility Name
Klinikum Oldenburg
City
Oldenburg
ZIP/Postal Code
D-26133
Country
Germany
Facility Name
Paracelsus - Klinik Osnabrück
City
Osnabrück
ZIP/Postal Code
D-49076
Country
Germany
Facility Name
Municipal Hospital Complex
City
Pforzheim
ZIP/Postal Code
D-49 7231 9690
Country
Germany
Facility Name
Klinikum Ernst Von Bergmann
City
Potsdam
ZIP/Postal Code
D-14467
Country
Germany
Facility Name
Kreiskrankenhaus Radebeul
City
Radebeul
ZIP/Postal Code
D-01445
Country
Germany
Facility Name
Krankenhaus St. Elisabeth - Ravensburg
City
Ravensburg
ZIP/Postal Code
D-88212
Country
Germany
Facility Name
Klinikum der Universitaet Regensburg
City
Regensburg
ZIP/Postal Code
D-93042
Country
Germany
Facility Name
Hematologische Onkologische Praxis
City
Regensburg
ZIP/Postal Code
D-93047
Country
Germany
Facility Name
Krankenhaus Barmherzige Brueder Regensburg
City
Regensburg
ZIP/Postal Code
D-93049
Country
Germany
Facility Name
Jakobi Krankenhaus
City
Rheine
ZIP/Postal Code
D-48431
Country
Germany
Facility Name
Klinik und Poliklinik fuer Innere Medizin - Universitaet Rostock
City
Rostock
ZIP/Postal Code
D-18057
Country
Germany
Facility Name
Klinik und Poliklinik fuer Strahlentherapie - Universitaetsklinikum Rostock
City
Rostock
ZIP/Postal Code
D-18057
Country
Germany
City
Rostock
ZIP/Postal Code
D-18257
Country
Germany
Facility Name
Caritasklinik St. Theresia
City
Saarbrucken
ZIP/Postal Code
D-66113
Country
Germany
Facility Name
Schwerpunktpraxis fuer Haematologie und Onkologie
City
Saarbrucken
ZIP/Postal Code
D-66113
Country
Germany
Facility Name
St. Elizabeth-Klinik Saarlouis
City
Saarlouis
ZIP/Postal Code
D-66713
Country
Germany
Facility Name
Martin - Luther Hospital
City
Schleswig
ZIP/Postal Code
D-24837
Country
Germany
Facility Name
Deaconess Hospital
City
Schwabisch Hall
ZIP/Postal Code
D-74523
Country
Germany
Facility Name
Leopoldina - Krankenhaus
City
Schweinfurt
ZIP/Postal Code
D-97422
Country
Germany
Facility Name
Evang. Jung-Stilling Hospital
City
Siegen
ZIP/Postal Code
D-57074
Country
Germany
Facility Name
St. Lukas - Clinic Solingen
City
Solingen
ZIP/Postal Code
D-42697
Country
Germany
Facility Name
Klinik fuer Onkologie - Katharinenhospital Stuttgart
City
Stuttgart
ZIP/Postal Code
D-70174
Country
Germany
Facility Name
Diakonie Klinikum Stuttgart
City
Stuttgart
ZIP/Postal Code
D-70176
Country
Germany
Facility Name
Klinikum Stuttgart - Buergerhospital
City
Stuttgart
ZIP/Postal Code
D-70191
Country
Germany
Facility Name
Hospital Bad Cannstatt
City
Stuttgart
ZIP/Postal Code
D-70374
Country
Germany
Facility Name
Robert-Bosch-Krankenhaus
City
Stuttgart
ZIP/Postal Code
D-70376
Country
Germany
Facility Name
St. Elisabeth Hospital Thuine
City
Thuine
ZIP/Postal Code
D-49832
Country
Germany
Facility Name
Regional Hospital Traunstein
City
Traunstein
ZIP/Postal Code
D-83278
Country
Germany
Facility Name
Krankenanstalt Mutterhaus der Borromaerinnen
City
Trier
ZIP/Postal Code
D-54290
Country
Germany
City
Trier
ZIP/Postal Code
D-54290
Country
Germany
Facility Name
Krankenhaus Der Barmherzigen Brueder
City
Trier
ZIP/Postal Code
D-54292
Country
Germany
Facility Name
Hospital Tutzing
City
Tutzing
ZIP/Postal Code
D-82327
Country
Germany
Facility Name
Comprehensive Cancer Center Ulm at Universitaetsklinikum Ulm
City
Ulm
ZIP/Postal Code
D-89081
Country
Germany
Facility Name
Ev. Hospital Unna
City
Unna
ZIP/Postal Code
D-59403
Country
Germany
Facility Name
St. Marienhospital - Vechta
City
Vechta
ZIP/Postal Code
D-49377
Country
Germany
Facility Name
Klinikum Der Stadt Villingen - Schwenningen
City
Villingen-Schwenningen
ZIP/Postal Code
D-78045
Country
Germany
Facility Name
Regional Hospital Waldbrol
City
Waldbrol
ZIP/Postal Code
D-51545
Country
Germany
Facility Name
Hospital Wetzler
City
Wetzlar
ZIP/Postal Code
D-35578
Country
Germany
Facility Name
Deutsche Klinik fuer Diagnostik
City
Wiesbaden
ZIP/Postal Code
D-65191
Country
Germany
Facility Name
Dr. Horst-Schmidt-Kliniken
City
Wiesbaden
ZIP/Postal Code
D-65199
Country
Germany
Facility Name
Ev. Hospital Witten-Herdecke
City
Witten
ZIP/Postal Code
D-58455
Country
Germany
Facility Name
University Wurzburg
City
Wuerzburg
ZIP/Postal Code
D-97070
Country
Germany
Facility Name
Kliniken St. Antonius
City
Wuppertal
ZIP/Postal Code
D-42283
Country
Germany
Facility Name
Municipal Hospital Complex Zwickau
City
Zwickau
ZIP/Postal Code
D-08060
Country
Germany
Facility Name
UniversitaetsSpital Zuerich
City
Zurich
ZIP/Postal Code
CH-8091
Country
Switzerland
Facility Name
City Hospital Triemli
City
Zurich
ZIP/Postal Code
D-8063
Country
Switzerland
12. IPD Sharing Statement
Citations:
PubMed Identifier
18212092
Citation
Trumper L, Zwick C, Ziepert M, Hohloch K, Schmits R, Mohren M, Liersch R, Bentz M, Graeven U, Wruck U, Hoffmann M, Metzner B, Hasenclever D, Loeffler M, Pfreundschuh M; German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL). Dose-escalated CHOEP for the treatment of young patients with aggressive non-Hodgkin's lymphoma: I. A randomized dose escalation and feasibility study with bi- and tri-weekly regimens. Ann Oncol. 2008 Mar;19(3):538-44. doi: 10.1093/annonc/mdm497. Epub 2008 Jan 22.
Results Reference
background
PubMed Identifier
18065407
Citation
Pfreundschuh M, Zwick C, Zeynalova S, Duhrsen U, Pfluger KH, Vrieling T, Mesters R, Mergenthaler HG, Einsele H, Bentz M, Lengfelder E, Trumper L, Rube C, Schmitz N, Loeffler M; German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL). Dose-escalated CHOEP for the treatment of young patients with aggressive non-Hodgkin's lymphoma: II. Results of the randomized high-CHOEP trial of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL). Ann Oncol. 2008 Mar;19(3):545-52. doi: 10.1093/annonc/mdm514. Epub 2007 Dec 6.
Results Reference
result
Learn more about this trial
Combination Chemotherapy Followed By Radiation Therapy in Treating Patients With Aggressive Non-Hodgkin's Lymphoma
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