Hormone Therapy With or Without Docetaxel And Estramustine in Treating Patients With Prostate Cancer That is Locally Advanced or At High Risk of Relapse
Prostate Cancer

About this trial
This is an interventional treatment trial for Prostate Cancer focused on measuring stage III prostate cancer, stage IIB prostate cancer, stage IIA prostate cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed adenocarcinoma of the prostate Locally advanced disease or at high risk for relapse No clinically or radiologically suspected metastases Prior lymphadenectomy required Meets at least 1 of the following criteria for poor prognosis: Gleason score greater than 7 T3 or T4 disease Prostate-specific antigen greater than 20 ng/mL N1 disease PATIENT CHARACTERISTICS: Age Under 80 Performance status ECOG 0-2 Life expectancy More than 10 years Hematopoietic Absolute neutrophil count greater than 1,500/mm^3 Platelet count at least 100,000/mm^3 Hepatic AST and ALT no greater than 1.5 times upper limit of normal (ULN) Bilirubin no greater than ULN Renal Creatinine less than 1.6 mg/dL OR Creatinine clearance greater than 60 mL/min Cardiovascular No uncontrolled or severe cardiovascular disease No prior thrombosis Pulmonary No prior pulmonary embolus Other No active infection No intolerance to aspirin No other prior malignancy except basal cell skin cancer No physical or psychological condition that would preclude study compliance PRIOR CONCURRENT THERAPY: Biologic therapy No concurrent immunotherapy Chemotherapy No prior chemotherapy No other concurrent chemotherapy Endocrine therapy No prior hormonal therapy No other concurrent hormonal therapy Radiotherapy Not specified Surgery See Disease Characteristics Other No other concurrent anticancer therapy
Sites / Locations
- Centre Paul Papin
- Hopital Saint Andre
- Institut Bergonie
- Hopital Ambroise Pare
- Centre Regional Francois Baclesse
- Polyclinique du Parc
- Centre Hospitalier Universitaire Henri Mondor
- Clinique Sainte-Marguerite
- Centre Hospitalier Departemental
- Centre Hospital Universitaire Hop Huriez
- Centre Hospital Regional Universitaire de Limoges
- Polyclinique des Quatre Pavillons
- Centre Leon Berard
- Marseille Institute of Cancer - Institut J. Paoli and I. Calmettes
- CHU de la Timone
- Hopital Notre-Dame de Bon Secours
- Hopital Clinique Claude Bernard
- Centre Hospitalier General de Mont de Marsan
- Hopital Lapeyronie-CHU Montpellier
- Centre Regional de Lutte Contre le Cancer - Centre Val d'Aurelle
- Centre Catherine de Sienne
- Centre Antoine Lacassagne
- Hopital Europeen Georges Pompidou
- Hopital de la Croix St. Simon
- Institut Curie Hopital
- Hopital Saint Joseph
- Hopital Tenon
- Institut Jean Godinot
- Centre Eugene Marquis
- Centre Hospitalier de Rodez
- Centre Henri Becquerel
- Centre Rene Huguenin
- CRLCC Nantes - Atlantique
- Hopital Foch
- Institut Claudius Regaud
- Centre Hospitalier Universitaire Bretonneau de Tours
- Centre Alexis Vautrin
- Institut Gustave Roussy
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Chemotherapy
Without Chemotherapy