Improving Retention of Hispanics Receiving Antidepressant Therapy

Inclusion Criteria: Diagnostic Statistical Manual, 4th edition criteria for Major Depressive Disorder Patients who self-identify as Hispanic and are Spanish-dominant, English-dominant, or bilingual Acceptable methods of contraception Hamilton Depression Rating Scale score >= 18 at Visit 1 Sertraline or venlafaxine ER is clinically appropriate Exclusion Criteria: History of schizophrenia, bipolar affective disorder, schizoaffective disorder, depression with psychotic symptoms, or organic brain syndrome DSM-IV criteria for alcohol or substance abuse or dependence during the 6 months prior to screening Pregnancy or breast-feeding At risk for committing suicide Clinically significant renal, pulmonary, cerebrovascular, cardiovascular, gastrointestinal, or endocrine disorders Glaucoma, history of increased intraocular pressure (IOP), or at risk for having increased IOP Untreated or unstable hypertension Clinically significant laboratory abnormalities or abnormal electrocardiogram Medical conditions that might interfere with the process of drug absorption, metabolism, or elimination Clinically significant thyroid dysfunction (except patients who are stable and asymptomatic on thyroid replacement therapy) Current or past history of seizure disorder (except febrile seizure in childhood) History of failed sertraline or venlafaxine treatment for at least 4 weeks at adequate doses Allergy or hypersensitivity to sertraline or venlafaxine History of two failed selective serotonin reuptake inhibitor (SSRI) trials for major depression at adequate doses and duration Monoamine oxidase inhibitors (MAOIs) or fluoxetine within 4 weeks prior to screening, or other SSRIs, antidepressants, neuroleptics, mood stabilizers, buspirone, benzodiazepines, or other psychotropic drugs (except zolpidem for insomnia) within 2 weeks prior to screening Electroconvulsive Therapy (ECT) within the last 3 months Effective medication or psychotherapy