Field Administration of Stroke Therapy - Magnesium (FAST-MAG) Trial (FAST-MAG)
Cerebrovascular Accident
About this trial
This is an interventional treatment trial for Cerebrovascular Accident focused on measuring stroke, brain attack, magnesium sulfate, neuroprotection, prehospital care, emergency medical services
Eligibility Criteria
Inclusion Criteria: Suspected stroke identified by the Los Angeles Prehospital Stroke Screen Age 40-95, inclusive Last known well time within 2 hours of treatment initiation Deficit present for >/= 15 minutes Exclusion Criteria: Coma Rapidly improving neurologic deficit Pre-existing neurologic, psychiatric, or advanced systemic disease that would confound the neurological or functional outcome evaluations Systolic Blood Pressure (SBP) < 90 or > 220 Known severe renal dysfunction (on dialysis or known chronic creatinine > 3.0) Severe respiratory distress (O2 sat < 90% or respiratory rate < 12 or >/= 24) Known second or third degree heart block with no pacemaker in place Major head trauma in the last 24 hours Recent stroke within prior 30 days Patient unable to give informed consent and no available on scene consent or assent provider
Sites / Locations
- The Clinical Coordinating Center is: UCLA School of Medicine, 710 Westwood Plaza
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Magnesium Sulfate
Normal saline
Magnesium sulfate (Mg) was administered intravenously with a 15 minute bolus load followed by a 24 hour infusion. The bolus-loading dose consisted of 4 grams Mg in 54 ml normal saline. The maintenance infusion contained 16 grams Mg diluted in 240 ml 0.9% normal saline, infused at 10 ml/hr for 24 hours. Paramedics in the field initiated the bolus-loading dose, administered at 216 ml/hr over 15 minutes through a rate controlled IV infusion set. The maintenance infusion was initiated in hospital immediately upon completion of the loading dose.
Normal saline was administered intravenously with a 15 minute bolus load followed by a 24 hour infusion. Paramedics in the field initiated the bolus-loading dose of 54 ml normal saline, administered at 216 ml/hr over 15 minutes through a rate controlled IV infusion set. The maintenance infusion was initiated in hospital immediately upon completion of the loading dose at 10 ml/hr for 24 hours.