Interstitial Brachytherapy With or Without External-Beam Radiation Therapy in Treating Patients With Prostate Cancer
Prostate Cancer
About this trial
This is an interventional treatment trial for Prostate Cancer focused on measuring stage IIB prostate cancer, stage IIA prostate cancer, adenocarcinoma of the prostate
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed adenocarcinoma of the prostate T1c-T2b, N0, M0 Intermediate-risk disease, as defined by 1 of the following: Gleason score < 7 AND prostate-specific antigen (PSA) 10-20 ng/mL Gleason score 7 AND PSA < 10 ng/mL No evidence of distant metastases Prostate volume ≤ 60 cc by transrectal ultrasonography American Urological Association voiding symptom score no greater than 15 (alpha blockers allowed) PATIENT CHARACTERISTICS: Age 18 and over Performance status Zubrod 0-1 Life expectancy Not specified Hematopoietic Not specified Hepatic Not specified Renal Not specified Other Patients must use effective contraception No other malignancy within the past 5 years except basal cell or squamous cell skin cancer or carcinoma in situ at any other site No major medical or psychiatric illness that would preclude study therapy No hip prosthesis PRIOR CONCURRENT THERAPY: Biologic therapy Not specified Chemotherapy No prior chemotherapy Endocrine therapy Prior neoadjuvant hormonal therapy allowed provided the following are true: Therapy was initiated within 2-6 months of study enrollment Therapy was no more than 6 months in duration Use of 5-alpha reductase inhibitors (e.g., finasteride) is discontinued before registration No concurrent hormonal therapy Radiotherapy No prior pelvic radiotherapy Surgery No prior radical surgery for prostate cancer No prior transurethral resection of the prostate No prior cryosurgery Other No prior transurethral needle ablation of the prostate No prior transurethral microwave thermotherapy of the prostate
Sites / Locations
- Arizona Oncology Services Foundation
- Auburn Radiation Oncology
- Alta Bates Summit Comprehensive Cancer Center
- Peninsula Medical Center
- Radiation Oncology Centers - Cameron Park
- Mercy Cancer Center at Mercy San Juan Medical Center
- East Bay Radiation Oncology Center
- Valley Medical Oncology Consultants - Castro Valley
- Valley Medical Oncology
- California Cancer Center - Woodward Park Office
- Kaiser Permanente Medical Center - Hayward
- Contra Costa Regional Medical Center
- El Camino Hospital Cancer Center
- Sutter Health - Western Division Cancer Research Group
- Alta Bates Summit Medical Center - Summit Campus
- Bay Area Breast Surgeons, Incorporated
- CCOP - Bay Area Tumor Institute
- Larry G Strieff MD Medical Corporation
- Tom K Lee, Incorporated
- Kaiser Permanente - Division of Research - Oakland
- Kaiser Permanente Medical Center - Oakland
- Kaiser Permanente Medical Center - Rancho Cordova
- Kaiser Permanente Medical Center - Redwood City
- Kaiser Permanente Medical Center - Richmond
- Rohnert Park Cancer Center
- Kaiser Permanente Medical Center - Roseville
- Radiation Oncology Center - Roseville
- Radiological Associates of Sacramento Medical Group, Incorporated
- Mercy General Hospital
- South Sacramento Cancer Center
- South Sacramento Kaiser-Permanente Medical Center
- Kaiser Permanente Medical Center - Sacramento
- Kaiser Permanente Medical Center - San Francisco Geary Campus
- UCSF Helen Diller Family Comprehensive Cancer Center
- California Pacific Medical Center - California Campus
- Kaiser Permanente Medical Center - Santa Teresa
- Kaiser Foundation Hospital - San Rafael
- Kaiser Permanente Medical Center - Santa Clara Kiely Campus
- Kaiser Permanente Medical Center - Santa Rosa
- Kaiser Permanente Medical Center - South San Francisco
- Kaiser Permanente Medical Facility - Stockton
- Solano Radiation Oncology Center
- Sutter Solano Medical Center
- Kaiser Permanente Medical Center - Walnut Creek
- Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
- Hospital of Saint Raphael
- CCOP - Christiana Care Health Services
- Sibley Memorial Hospital
- Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
- Ella Milbank Foshay Cancer Center at Jupiter Medical Center
- CCOP - Mount Sinai Medical Center
- Northeast Georgia Medical Center
- Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
- Cancer Institute at St. John's Hospital
- Regional Cancer Center at Memorial Medical Center
- Menorah Medical Center
- CCOP - Kansas City
- Greenebaum Cancer Center at University of Maryland Medical Center
- St. Agnes Hospital Cancer Center
- Cape Cod Hospital
- Shields Radiation Oncology Center - Mansfield
- South Suburban Oncology Center
- Winchester Hospital Radiation Oncology Center
- Hickman Cancer Center at Bixby Medical Center
- Saint Joseph Mercy Cancer Center
- CCOP - Michigan Cancer Research Consortium
- Oakwood Cancer Center at Oakwood Hospital and Medical Center
- Genesys Hurley Cancer Institute
- Hurley Medical Center
- Van Elslander Cancer Center at St. John Hospital and Medical Center
- Foote Memorial Hospital
- Sparrow Regional Cancer Center
- St. Mary Mercy Hospital
- St. Joseph Mercy Oakland
- Mercy Regional Cancer Center at Mercy Hospital
- Seton Cancer Institute at Saint Mary's - Saginaw
- St. John Macomb Hospital
- Mayo Clinic Cancer Center
- Saint Luke's Cancer Institute at Saint Luke's Hospital
- St. Joseph Medical Center
- North Kansas City Hospital
- Parvin Radiation Oncology
- Research Medical Center
- Liberty Hospital
- Heartland Regional Medical Center
- Saint Joseph Oncology, Incorporated
- Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
- Barnes-Jewish West County Hospital
- Siteman Cancer Center at Barnes-Jewish St. Peters Hospital - St. Peters
- CCOP - Nevada Cancer Research Foundation
- Nevada Cancer Institute
- Renown Institute for Cancer at Renown Regional Medical Center
- Kingsbury Center for Cancer Care at Cheshire Medical Center
- Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
- Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
- Fox Chase Virtua Health Cancer Program at Virtua West Jersey
- New York Methodist Hospital
- Roswell Park Cancer Institute
- Sands Cancer Center
- Beth Israel Medical Center - Petrie Division
- Highland Hospital of Rochester
- University Radiation Oncology at Parkridge Hospital
- James P. Wilmot Cancer Center at University of Rochester Medical Center
- Blumenthal Cancer Center at Carolinas Medical Center
- Coleman Radiation Oncology Center at Carter General Hospital
- CarolinaEast Cancer Care
- South Atlantic Radiation Oncology, LLC
- Coastal Carolina Radiation Oncology Center
- Summa Center for Cancer Care at Akron City Hospital
- Radiation Oncology Center
- Barberton Citizens Hospital
- Adena Regional Medical Center
- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center
- Riverside Methodist Hospital Cancer Care
- CCOP - Columbus
- Grant Medical Center Cancer Care
- Mount Carmel Health - West Hospital
- Doctors Hospital at Ohio Health
- Grady Memorial Hospital
- Community Cancer Center
- Hematology Oncology Center
- Lima Memorial Hospital
- Strecker Cancer Center at Marietta Memorial Hospital
- Northwest Ohio Oncology Center
- Licking Memorial Cancer Care Program at Licking Memorial Hospital
- St. Charles Mercy Hospital
- Cancer Care Center, Incorporated
- North Coast Cancer Care, Incorporated
- Community Hospital of Springfield and Clark County
- Flower Hospital Cancer Center
- Mercy Hospital of Tiffin
- Toledo Hospital
- St. Vincent Mercy Medical Center
- Medical University of Ohio Cancer Center
- CCOP - Toledo Community Hospital
- St. Anne Mercy Hospital
- Toledo Clinic, Incorporated - Main Clinic
- Mount Carmel St. Ann's Cancer Center
- Cancer Treatment Center
- Genesis - Good Samaritan Hospital
- Geisinger Cancer Institute at Geisinger Health
- Fox Chase Cancer Center - Philadelphia
- McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center
- Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
- York Cancer Center at Apple Hill Medical Center
- M. D. Anderson Cancer Center at University of Texas
- Sandra L. Maxwell Cancer Center
- Logan Regional Hospital
- Jon and Karen Huntsman Cancer Center at Intermountain Medical Center
- Val and Ann Browning Cancer Center at McKay-Dee Hospital Center
- Utah Valley Regional Medical Center - Provo
- Dixie Regional Medical Center - East Campus
- Utah Cancer Specialists at UCS Cancer Center
- LDS Hospital
- Norris Cotton Cancer Center - North
- Fredericksburg Oncology, Incorporated
- Veterans Affairs Medical Center - Richmond
- St. Francis Hospital
- Good Samaritan Cancer Center
- Franciscan Cancer Center at St. Joseph Medical Center
- CCOP - Northwest
- MultiCare Regional Cancer Center at Tacoma General Hospital
- Columbia Saint Mary's Hospital - Ozaukee
- Columbia-Saint Mary's Cancer Care Center
- Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center
- All Saints Cancer Center at Wheaton Franciscan Healthcare
- West Allis Memorial Hospital
- Cross Cancer Institute at University of Alberta
- Princess Margaret Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
EBRT + Brachytherapy
Brachytherapy Only
External beam radiation therapy (EBRT) and transperineal interstitial permanent brachytherapy (100/110)
Transperineal interstitial permanent brachytherapy (125/145)