Doxorubicin Hydrochloride, Cisplatin, and Paclitaxel or Carboplatin and Paclitaxel in Treating Patients With Stage III-IV or Recurrent Endometrial Cancer
Recurrent Uterine Corpus Carcinoma, Stage IIIA Uterine Corpus Cancer AJCC v7, Stage IIIB Uterine Corpus Cancer AJCC v7
About this trial
This is an interventional treatment trial for Recurrent Uterine Corpus Carcinoma
Eligibility Criteria
Inclusion Criteria: Patients must have primary stage III or stage IV or recurrent endometrial carcinoma whose potential for cure by radiation therapy or surgery alone or in combination is very poor; pathological confirmation and estrogen receptor (ER)/progesterone receptor (PR) status of the primary tumor is mandatory; however, the results do not need to be available prior to registration Patients may not have received prior cytotoxic chemotherapy, including chemotherapy used for radiation sensitization; patients may have received prior radiation therapy, hormonal therapy, or therapy with biologic agents, but such therapies must be discontinued prior to entry on this study Patients in whom both radiation and chemotherapy is planned must receive radiation prior to entry on this study; at least four weeks should have elapsed since completion of radiation therapy (RT) involving the whole pelvis or over 50% of the spine Platelets >= 100,000/mcl Granulocytes (absolute neutrophil count [ANC]) >= 1,500/mcl Creatinine =< upper limit of normal (ULN) (Common Toxicity Criteria [CTC] grade 0) or calculated creatinine clearance (Jeliffe Formula) >= 60 ml/min Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) =< 3 x upper limits of normal Bilirubin =< institutional upper limits of normal Patients must have a Gynecologic Oncology Group (GOG) performance status of 0, 1, or 2 Patients must have met the pre-entry requirements Patients must have signed an approved informed consent and authorization permitting release of personal health information Exclusion Criteria: Patients with a concomitant malignancy other than non-melanoma skin cancer; with the exception of non-melanoma skin cancer, patients with a prior invasive malignancy who have been disease-free for < 5 years or who received prior chemotherapy for that malignancy Patients in whom pathological confirmation and estrogen receptor (ER)/progesterone receptor (PR) status of the tumor is not obtainable Patients for whom radiation therapy is planned during or after study chemotherapy prior to demonstrated progression Patients with concomitant medical illness such as serious uncontrolled infection, uncontrolled angina, or serious peripheral neuropathy, which, in the opinion of the treating physician, make the treatments prescribed on this study unreasonably hazardous for the patient Patients with third degree or complete heart block are not eligible unless a pacemaker is in place; patients on medications which alter cardiac conduction, such as digitalis, beta-blockers, or calcium channel blockers, or who have other conduction abnormalities or cardiac dysfunction may be placed on study at the discretion of the investigator Patients with history of myocardial infarct within 6 months before enrollment, New York Heart Association (NYHA) class II or greater heart failure or symptoms suspicious for congestive heart failure are not eligible unless a left ventricular ejection fraction in the past 6 months is documented to be 50% or greater; patients who have had a left ventricular ejection fraction (LVEF) (performed for any reason) of less than 50% in the past 6 months are ineligible Patients whose circumstances will not permit study completion or adequate follow-up Patients who are sensitive to E. coli-derived drug preparations Patients with uterine carcinosarcoma or other non-epithelial uterine malignancies
Sites / Locations
- University of Alabama at Birmingham Cancer Center
- Clearview Cancer Institute
- Mobile Infirmary Medical Center
- Providence Hospital
- Providence Alaska Medical Center
- Mayo Clinic in Arizona
- Highlands Oncology Group PA - Fayetteville
- Washington Regional Medical Center - Fayetteville
- University of Arkansas for Medical Sciences
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
- John Muir Medical Center-Concord Campus
- City of Hope Comprehensive Cancer Center
- Kaiser Permanente-Fremont
- Saint Jude Medical Center
- Marin Cancer Care Inc
- Long Beach Memorial Medical Center-Todd Cancer Institute
- Kaiser Permanente Los Angeles Medical Center
- USC / Norris Comprehensive Cancer Center
- Cedars Sinai Medical Center
- UCLA / Jonsson Comprehensive Cancer Center
- Community Hospital of Los Gatos
- Doctors Medical Center
- Memorial Medical Center
- Kaiser Permanente-Oakland
- UC Irvine Health/Chao Family Comprehensive Cancer Center
- Stanford Cancer Institute Palo Alto
- Kaiser Permanente-Redwood City
- Kaiser Permanente-Richmond
- Kaiser Permanente-Roseville
- Sutter Roseville Medical Center
- Sutter Medical Center Sacramento
- University of California Davis Comprehensive Cancer Center
- Kaiser Permanente-South Sacramento
- Kaiser Permanente - Sacramento
- Salinas Valley Memorial
- University of California San Diego
- Alvarado Hospital Medical Center
- Zuckerberg San Francisco General Hospital
- Kaiser Permanente-San Francisco
- UCSF Medical Center-Mount Zion
- Kaiser Permanente-Santa Teresa-San Jose
- Kaiser Permanente San Leandro
- Kaiser Permanente-San Rafael
- Cancer Center of Santa Barbara
- Ridley-Tree Cancer Center
- Sansum Clinic Inc
- Kaiser Permanente Medical Center - Santa Clara
- Kaiser Permanente-Santa Rosa
- Ridley-Tree Cancer Center-Solvang
- Kaiser Permanente-South San Francisco
- Kaiser Permanente-Stockton
- Olive View-University of California Los Angeles Medical Center
- Kaiser Permanente-Vallejo
- Kaiser Permanente-Walnut Creek
- John Muir Medical Center-Walnut Creek
- Colorado Gynecologic Oncology Group
- University of Colorado
- Rocky Mountain Gynecologic Oncology PC
- Poudre Valley Hospital
- Hartford Hospital
- Smilow Cancer Hospital Care Center at Saint Francis
- The Hospital of Central Connecticut
- Yale University
- Beebe Medical Center
- Christiana Care Health System-Christiana Hospital
- TidalHealth Nanticoke / Allen Cancer Center
- Saint Francis Hospital - Wilmington
- MedStar Washington Hospital Center
- Morton Plant Hospital
- Broward Health Medical Center
- Florida Gynecologic Oncology
- Saint Vincent's Medical Center
- Mayo Clinic in Florida
- Jupiter Medical Center
- Mercy Hospital
- University of Miami Miller School of Medicine-Sylvester Cancer Center
- AdventHealth Orlando
- Orlando Health Cancer Institute
- Bayfront Outpatient Health Clinic
- Sarasota Memorial Hospital
- Moffitt Cancer Center
- Florida Cancer Specialists-West Palm Beach
- Southeastern Gynecologic Oncology LLP
- Piedmont Hospital
- Atlanta Regional CCOP
- Emory Saint Joseph's Hospital
- Northside Hospital
- Augusta University Medical Center
- WellStar Cobb Hospital
- John B Amos Cancer Center
- Dekalb Medical Center
- Northeast Georgia Medical Center-Gainesville
- Northside Hospital - Gwinnett
- Central Georgia Gynecologic Oncology
- Wellstar Kennestone Hospital
- Southern Regional Medical Center
- Harbin Clinic Medical Oncology and Clinical Research
- Memorial Health University Medical Center
- Pali Momi Medical Center
- Hawaii Cancer Care Inc - Waterfront Plaza
- Queen's Medical Center
- Straub Clinic and Hospital
- University of Hawaii Cancer Center
- Queen's Cancer Center - Kuakini
- The Cancer Center of Hawaii-Liliha
- Kapiolani Medical Center for Women and Children
- Pacific Cancer Institute of Maui
- Saint Anthony's Health
- Northwest Community Hospital
- Rush - Copley Medical Center
- Saint Joseph Medical Center
- Graham Hospital Association
- Memorial Hospital
- Mount Sinai Hospital Medical Center
- Northwestern University
- Rush University Medical Center
- University of Illinois
- Swedish Covenant Hospital
- University of Chicago Comprehensive Cancer Center
- Decatur Memorial Hospital
- Heartland Cancer Research NCORP
- Eureka Hospital
- NorthShore University HealthSystem-Evanston Hospital
- Saint Francis Hospital
- Galesburg Cottage Hospital
- Illinois CancerCare-Galesburg
- Western Illinois Cancer Treatment Center
- Ingalls Memorial Hospital
- Mason District Hospital
- Hinsdale Hematology Oncology Associates Incorporated
- Hopedale Medical Complex - Hospital
- Duly Health and Care Joliet
- Presence Saint Mary's Hospital
- Kewanee Hospital
- Mcdonough District Hospital
- Loyola University Medical Center
- Good Samaritan Regional Health Center
- Bromenn Regional Medical Center
- Carle Cancer Institute Normal
- Franciscan St. James Health-Olympia Fields Campus
- Illinois CancerCare-Ottawa Clinic
- Ottawa Regional Hospital and Healthcare Center
- Chicago Gynecologic Oncology SC
- Advocate Lutheran General Hospital
- OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
- Pekin Hospital
- Proctor Hospital
- Illinois CancerCare-Peoria
- Methodist Medical Center of Illinois
- OSF Saint Francis Medical Center
- Illinois Valley Hospital
- Valley Radiation Oncology
- Perry Memorial Hospital
- Swedish American Hospital
- OSF Saint Anthony Medical Center
- Sarah Culbertson Memorial Hospital
- Saint Margaret's Hospital
- Memorial Medical Center
- Carle Cancer Center
- Franciscan Saint Francis Health-Beech Grove
- Elkhart General Hospital
- Fort Wayne Medical Oncology and Hematology Inc-Parkview
- Indiana University/Melvin and Bren Simon Cancer Center
- Saint Vincent Hospital and Health Care Center
- Community Howard Regional Health
- IU Health La Porte Hospital
- Franciscan Saint Anthony Health-Michigan City
- Saint Joseph Regional Medical Center-Mishawaka
- Reid Health
- Memorial Hospital of South Bend
- Michiana Hematology Oncology PC-South Bend
- South Bend Clinic
- Northern Indiana Cancer Research Consortium
- McFarland Clinic PC - Ames
- University of Iowa Healthcare Cancer Services Quad Cities
- Saint Luke's Hospital
- Mercy Hospital
- Oncology Associates at Mercy Medical Center
- Medical Oncology and Hematology Associates-West Des Moines
- Genesis Medical Center - East Campus
- Genesis Cancer Care Institute
- Mercy Capitol
- Iowa Methodist Medical Center
- Iowa-Wide Oncology Research Coalition NCORP
- Medical Oncology and Hematology Associates-Des Moines
- Medical Oncology and Hematology Associates-Laurel
- Mercy Medical Center - Des Moines
- Iowa Lutheran Hospital
- University of Iowa/Holden Comprehensive Cancer Center
- Mercy Medical Center - North Iowa
- Siouxland Regional Cancer Center
- Mercy Medical Center-Sioux City
- Saint Luke's Regional Medical Center
- Cancer Center of Kansas - Chanute
- Cancer Center of Kansas - Dodge City
- Cancer Center of Kansas - El Dorado
- Cancer Center of Kansas-Independence
- Providence Medical Center
- University of Kansas Cancer Center
- Cancer Center of Kansas-Kingman
- Lawrence Memorial Hospital
- Southwest Medical Center
- Cancer Center of Kansas - Newton
- Menorah Medical Center
- Radiation Oncology Practice Corporation Southwest
- Cancer Center of Kansas - Parsons
- Ascension Via Christi - Pittsburg
- Cancer Center of Kansas - Pratt
- Cancer Center of Kansas - Salina
- Advent Health - Shawnee Mission Medical Center
- Cotton O'Neil Cancer Center / Stormont Vail Health
- University of Kansas Health System Saint Francis Campus
- Cancer Center of Kansas - Wellington
- Associates In Womens Health
- Cancer Center of Kansas-Wichita Medical Arts Tower
- Ascension Via Christi Hospitals Wichita
- Cancer Center of Kansas - Wichita
- Wichita NCI Community Oncology Research Program
- Cancer Center of Kansas - Winfield
- Saint Elizabeth Medical Center South
- University of Kentucky/Markey Cancer Center
- Norton Hospital Pavilion and Medical Campus
- The James Graham Brown Cancer Center at University of Louisville
- Baton Rouge General Medical Center
- Mary Bird Perkins Cancer Center
- Woman's Hospital
- Louisiana State University Health Science Center
- Tulane University Health Sciences Center
- University Medical Center New Orleans
- Ochsner Medical Center Jefferson
- Maine Medical Center-Bramhall Campus
- University of Maryland/Greenebaum Cancer Center
- Greater Baltimore Medical Center
- MedStar Franklin Square Medical Center/Weinberg Cancer Institute
- Johns Hopkins University/Sidney Kimmel Cancer Center
- University of Maryland Shore Medical Center at Easton
- Christiana Care - Union Hospital
- Kaiser Permanente - Largo Medical Center
- Kaiser Permanente - Towson Medical Center
- Kaiser Permanente - Shady Grove Medical Center
- TidalHealth Peninsula Regional
- Tufts Medical Center
- Massachusetts General Hospital Cancer Center
- Brigham and Women's Hospital
- Dana-Farber Cancer Institute
- Dana Farber Community Cancer Care-Quincy
- Baystate Medical Center
- UMass Memorial Medical Center - University Campus
- Bixby Medical Center
- Hickman Cancer Center
- Michigan Cancer Research Consortium NCORP
- Saint Joseph Mercy Hospital
- University of Michigan Comprehensive Cancer Center
- Bronson Battle Creek
- Spectrum Health Big Rapids Hospital
- Beaumont Hospital - Dearborn
- Wayne State University/Karmanos Cancer Institute
- Henry Ford Hospital
- Ascension Saint John Hospital
- Green Bay Oncology - Escanaba
- Hurley Medical Center
- Genesys Regional Medical Center-West Flint Campus
- Cancer Research Consortium of West Michigan NCORP
- Mercy Health Saint Mary's
- Spectrum Health at Butterworth Campus
- Spectrum Health-Blodgett Campus
- Holland Community Hospital
- Green Bay Oncology - Iron Mountain
- Allegiance Health
- Bronson Methodist Hospital
- West Michigan Cancer Center
- Kalamazoo Center for Medical Studies
- Borgess Medical Center
- Sparrow Hospital
- Saint Mary Mercy Hospital
- Mercy Memorial Hospital
- Toledo Clinic Cancer Centers-Monroe
- Mercy Health Partners-Hackley Campus
- Mercy Health Mercy Campus
- McLaren Cancer Institute-Northern Michigan
- Saint Joseph Mercy Oakland
- Lake Huron Medical Center
- William Beaumont Hospital-Royal Oak
- Ascension Saint Mary's Hospital
- Lakeland Medical Center Saint Joseph
- Ascension Providence Hospitals - Southfield
- Munson Medical Center
- Saint John Macomb-Oakland Hospital
- Metro Health Hospital
- Sanford Joe Lueken Cancer Center
- Fairview Ridges Hospital
- Mercy Hospital
- Essentia Health Cancer Center
- Essentia Health Saint Mary's Medical Center
- Miller-Dwan Hospital
- Fairview Southdale Hospital
- Unity Hospital
- Minnesota Oncology Hematology PA-Maplewood
- Abbott-Northwestern Hospital
- University of Minnesota/Masonic Cancer Center
- North Memorial Medical Health Center
- Mayo Clinic in Rochester
- Metro Minnesota Community Oncology Research Consortium
- Park Nicollet Clinic - Saint Louis Park
- United Hospital
- Saint Francis Regional Medical Center
- Ridgeview Medical Center
- Minnesota Oncology Hematology PA-Woodbury
- Saint Dominic-Jackson Memorial Hospital
- University of Mississippi Medical Center
- Keesler Medical Center
- Singing River Hospital
- Southeast Missouri Hospital
- Saint Francis Medical Center
- University of Missouri - Ellis Fischel
- Centerpoint Medical Center LLC
- Freeman Health System
- Truman Medical Centers
- Saint Luke's Hospital of Kansas City
- Radiation Oncology Practice Corporation South
- Saint Joseph Health Center
- North Kansas City Hospital
- Research Medical Center
- Radiation Oncology Practice Corporation - North
- Liberty Radiation Oncology Center
- Heartland Regional Medical Center
- SSM Health Saint Louis University Hospital
- Saint Louis Cancer and Breast Institute-South City
- Washington University School of Medicine
- Saint Mary's Hospital
- Missouri Baptist Medical Center
- Center for Cancer Care and Research
- Mercy Hospital Saint Louis
- Saint Louis-Cape Girardeau CCOP
- Cancer Research for the Ozarks NCORP
- Mercy Hospital Springfield
- CoxHealth South Hospital
- Billings Clinic Cancer Center
- Northern Rockies Radiation Oncology Center
- Saint Vincent Healthcare
- Montana Cancer Consortium NCORP
- Saint Vincent Frontier Cancer Center
- Deaconess Medical Center
- Bozeman Deaconess Hospital
- Internal Medicine of Bozeman
- Saint James Community Hospital and Cancer Treatment Center
- Benefis Healthcare- Sletten Cancer Institute
- Berdeaux, Donald MD (UIA Investigator)
- Great Falls Clinic
- Northern Montana Hospital
- Saint Peter's Community Hospital
- Glacier Oncology PLLC
- Kalispell Medical Oncology
- Kalispell Regional Medical Center
- Eastern Montana Cancer Center
- Montana Cancer Specialists
- Saint Patrick Hospital - Community Hospital
- Community Medical Hospital
- Guardian Oncology and Center for Wellness
- CHI Health Good Samaritan
- Bryan LGH Medical Center West
- Bryan LGH Medical Center East
- Nebraska Cancer Research Center
- Saint Elizabeth Regional Medical Center
- Nebraska Methodist Hospital
- Alegent Health Immanuel Medical Center
- Alegent Health Bergan Mercy Medical Center
- Creighton University Medical Center
- University of Nebraska Medical Center
- University Medical Center of Southern Nevada
- Nevada Cancer Research Foundation NCORP
- Center of Hope at Renown Medical Center
- Renown Regional Medical Center
- Women's Cancer Center at Washoe
- Saint Mary's Regional Medical Center
- Dartmouth Hitchcock Medical Center
- Cooper Hospital University Medical Center
- Hunterdon Medical Center
- Saint Barnabas Medical Center
- Mountainside Hospital
- Morristown Medical Center
- Virtua Memorial
- Inspira Medical Center Mullica Hill
- Jersey Shore Medical Center
- Rutgers Cancer Institute of New Jersey
- Rutgers New Jersey Medical School
- AtlantiCare Regional Medical Center -Main Campus
- Riverview Medical Center/Booker Cancer Center
- Sparta Cancer Treatment Center
- Overlook Hospital
- Inspira Medical Center Vineland
- Virtua Voorhees
- University of New Mexico Cancer Center
- Southwest Gynecologic Oncology Associates Inc
- New York Oncology Hematology PC - Albany Medical Center
- Women's Cancer Care Associates LLC
- New York Oncology Hematology PC - Amsterdam
- Island Gynecologic Oncology
- Montefiore Medical Center-Einstein Campus
- Montefiore Medical Center-Wakefield Campus
- Montefiore Medical Center - Moses Campus
- State University of New York Downstate Medical Center
- Roswell Park Cancer Institute
- New York Oncology Hematology PC - Clifton Park
- New York Oncology Hematology PC-Hudson
- Northwell Health NCORP
- North Shore University Hospital
- Long Island Jewish Medical Center
- Laura and Isaac Perlmutter Cancer Center at NYU Langone
- Mount Sinai Hospital
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
- Memorial Sloan Kettering Cancer Center
- South Nassau Communities
- Stony Brook University Medical Center
- Good Samaritan Hospital Medical Center
- Randolph Hospital
- Hope Women's Cancer Centers-Asheville
- Cone Health Cancer Center at Alamance Regional
- UNC Lineberger Comprehensive Cancer Center
- Carolinas Medical Center/Levine Cancer Institute
- Novant Health Presbyterian Medical Center
- Duke University Medical Center
- Moorehead Memorial Hospital
- Wayne Memorial Hospital
- Wayne Radiation Oncology
- Cone Health Cancer Center
- Gynecologic Oncology Network
- Vidant Medical Center
- Vidant Oncology-Kinston
- FirstHealth of the Carolinas-Moore Regional Hospital
- Annie Penn Memorial Hospital
- Wilson Medical Center
- Novant Health Oncology Specialists
- Wake Forest University Health Sciences
- Mid Dakota Clinic
- Saint Alexius Medical Center
- Sanford Bismarck Medical Center
- Sanford Broadway Medical Center
- Summa Health System - Akron Campus
- Cleveland Clinic Akron General
- Saint Elizabeth Boardman Hospital
- Toledo Clinic Cancer Centers-Bowling Green
- Cleveland Clinic Mercy Hospital
- Aultman Health Foundation
- University of Cincinnati Cancer Center-UC Medical Center
- Good Samaritan Hospital - Cincinnati
- Case Western Reserve University
- MetroHealth Medical Center
- Cleveland Clinic Cancer Center/Fairview Hospital
- Cleveland Clinic Foundation
- North Coast Cancer Care-Clyde
- Ohio State University Comprehensive Cancer Center
- Riverside Methodist Hospital
- Mount Carmel Health Center West
- Grandview Hospital
- Good Samaritan Hospital - Dayton
- Miami Valley Hospital
- Miami Valley Hospital North
- Dayton Veterans Affairs Medical Center
- Dayton NCI Community Oncology Research Program
- Hematology Oncology Center Incorporated
- Blanchard Valley Hospital
- Atrium Medical Center-Middletown Regional Hospital
- Fremont Memorial Hospital
- Kettering Medical Center
- Saint Rita's Medical Center
- Lima Memorial Hospital
- Saint Luke's Hospital
- Toledo Clinic Cancer Centers-Maumee
- Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
- Hillcrest Hospital Cancer Center
- UH Seidman Cancer Center at Lake Health Mentor Campus
- Saint Charles Hospital
- Toledo Clinic Cancer Centers-Oregon
- UH Seidman Cancer Center at Salem Regional Medical Center
- Firelands Regional Medical Center
- North Coast Cancer Care
- ProMedica Flower Hospital
- Mercy Hospital of Tiffin
- ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
- Saint Vincent Mercy Medical Center
- University of Toledo
- Toledo Community Hospital Oncology Program CCOP
- Mercy Health - Saint Anne Hospital
- Toledo Clinic Cancer Centers-Toledo
- Upper Valley Medical Center
- Saint Joseph Warren Hospital
- Fulton County Health Center
- Clinton Memorial Hospital
- Cancer Treatment Center
- Wright-Patterson Medical Center
- Greene Memorial Hospital
- Saint Elizabeth Youngstown Hospital
- University of Oklahoma Health Sciences Center
- Oklahoma Cancer Specialists and Research Institute-Tulsa
- Three Rivers Community Hospital
- Asante Health System
- Providence Medford Medical Center
- Rogue Valley Medical Center
- Legacy Good Samaritan Hospital and Medical Center
- Compass Oncology Rose Quarter
- Kaiser Permanente Northwest
- Oregon Health and Science University
- Jefferson Abington Hospital
- Lehigh Valley Hospital-Cedar Crest
- Saint Luke's University Hospital-Bethlehem Campus
- Bryn Mawr Hospital
- Marion Community Hospital
- Mercy Fitzgerald Hospital
- Oncology Hematology Associates of Northern Pennsylvania
- Pocono Medical Center
- Ephrata Cancer Center
- Penn State Milton S Hershey Medical Center
- Riddle Memorial Hospital
- Paoli Memorial Hospital
- Drexel University School of Medicine
- University of Pennsylvania/Abramson Cancer Center
- Pennsylvania Hospital
- Thomas Jefferson University Hospital
- Fox Chase Cancer Center
- Jefferson Torresdale Hospital
- Temple University Hospital
- Einstein Medical Center Philadelphia
- UPMC-Magee Womens Hospital
- West Penn Hospital
- Guthrie Medical Group PC-Robert Packer Hospital
- Mercy Hospital
- Hematology and Oncology Associates of North East Pennsylvania
- Moses Taylor Hospital
- Scranton Hematology Oncology
- Associates In Hematology Oncology PC-Upland
- Reading Hospital
- Lankenau Medical Center
- Main Line Health NCORP
- Women and Infants Hospital
- Medical University of South Carolina
- Prisma Health Richland Hospital
- University of South Carolina School of Medicine
- South Carolina Oncology Associates PA
- Black Hills Obstetrics and Gynecology
- Sanford Cancer Center Oncology Clinic
- Sanford USD Medical Center - Sioux Falls
- Chattanooga's Program in Women's Oncology
- East Tennessee State University
- Southeast Gynecologic Oncology Associates
- East Tennessee Baptist Hospital-Mercy Health Partners
- Knoxville Gynecologic Cancer Specialists PC
- Baptist Memorial Hospital and Cancer Center-Memphis
- University of Tennessee Health Science Center
- Meharry Medical College
- Vanderbilt University/Ingram Cancer Center
- The Don and Sybil Harrington Cancer Center
- Parkland Memorial Hospital
- Clements University Hospital
- UT Southwestern/Simmons Cancer Center-Dallas
- Brooke Army Medical Center
- University of Texas Medical Branch
- Houston Methodist Hospital
- M D Anderson Cancer Center
- Texas Tech University Health Sciences Center-Lubbock
- Scott and White Memorial Hospital
- American Fork Hospital / Huntsman Intermountain Cancer Center
- Sandra L Maxwell Cancer Center
- Logan Regional Hospital
- Cottonwood Hospital Medical Center
- Intermountain Medical Center
- McKay-Dee Hospital Center
- Utah Valley Regional Medical Center
- Dixie Medical Center Regional Cancer Center
- Intermountain Health Care
- Utah Cancer Specialists-Salt Lake City
- Huntsman Cancer Institute/University of Utah
- LDS Hospital
- University of Vermont Medical Center
- Northern Virginia Pelvic Surgery Associates
- University of Virginia Cancer Center
- Danville Regional Medical Center
- Kaiser Permanente - Fair Oaks Medical Center
- Southside Community Hospital
- Fredericksburg Oncology Inc
- Peninsula Cancer Institute-Gloucester
- Virginia Oncology Associates-Hampton
- Rappahannock General Hospital
- Peninsula Cancer Institute-Newport News
- Bon Secours Mary Immaculate Hospital
- Virginia Oncology Associates - Lake Wright
- Bon Secours Saint Mary's Hospital
- Richmond Radiation Oncology Center
- Virginia Commonwealth University/Massey Cancer Center
- Oncology and Hematology Associates of Southwest Virginia
- Carilion Clinic Gynecological Oncology
- VCU Community Memorial Health Center
- Peninsula Cancer Institute-Williamsburg
- Fred Hutchinson Cancer Research Center
- University of Washington Medical Center - Montlake
- MultiCare Tacoma General Hospital
- Northwest Medical Specialties PLLC
- PeaceHealth Southwest Medical Center
- HSHS Sacred Heart Hospital
- Marshfield Clinic Cancer Center at Sacred Heart
- Saint Agnes Hospital/Agnesian Cancer Center
- Green Bay Oncology at Saint Vincent Hospital
- Saint Vincent Hospital Cancer Center Green Bay
- Green Bay Oncology Limited at Saint Mary's Hospital
- Saint Vincent Hospital Cancer Center at Saint Mary's
- Gundersen Lutheran Medical Center
- University of Wisconsin Hospital and Clinics
- Holy Family Memorial Hospital
- Bay Area Medical Center
- Marshfield Medical Center-Marshfield
- Marshfield Medical Center
- Ascension Columbia Saint Mary's Hospital Ozaukee
- Ascension Columbia Saint Mary's Hospital - Milwaukee
- Aurora Saint Luke's Medical Center
- Medical College of Wisconsin
- Marshfield Clinic-Minocqua Center
- ProHealth Oconomowoc Memorial Hospital
- Saint Vincent Hospital Cancer Center at Oconto Falls
- Ascension All Saints Hospital
- Ascension Saint Mary's Hospital
- Marshfield Medical Center-Rice Lake
- Vince Lombardi Cancer Clinic-Sheboygan
- Vince Lombardi Cancer Clinic - Slinger
- Ascension Saint Michael's Hospital
- Green Bay Oncology - Sturgeon Bay
- ProHealth Waukesha Memorial Hospital
- Marshfield Clinic-Wausau Center
- Aurora West Allis Medical Center
- Marshfield Medical Center - Weston
- Marshfield Clinic - Wisconsin Rapids Center
- Welch Cancer Center
- McGill University Health Centre at Royal Victoria Hospital
- Montreal General Hospital
- Saint Mary's Hospital
- CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)
- Tohoku University School of Medicine
- Kure National Hospital
- Hokkaido University Hospital
- Iwate Medical University Hospital
- Kagoshima City Hospital
- Jikei University Aoto Hospital
- Keio University
- Hiroshima University Hospital
- National Hospital Organization-Kobe Medical Center
- Shikoku Cancer Center
- National Kyushu Cancer Center
- Jikei University School of Medicine
- Saitama Medical University International Medical Center
- National Cancer Center Hospital
- Tottori University
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Arm I (doxorubicin hydrochloride, cisplatin, paclitaxel)
Arm II (paclitaxel, carboplatin)
Patients receive doxorubicin hydrochloride IV over approximately 15-30 minutes on day 1, cisplatin IV over 60-90 minutes on day 1, paclitaxel IV over 3 hours on day 2, and filgrastim SC on days 3-12 or pegfilgrastim SC on day 3. Treatment repeats every 21 days for 7 courses in the absence of disease progression or unacceptable toxicity.
Patients receive paclitaxel IV over 3 hours and carboplatin IV over 30-60 minutes on day 1. Treatment repeats every 21 days for 7 courses in the absence of disease progression or unacceptable toxicity.