Therapy for Reading Problems in Adults After Brain Injury
Primary Purpose
Dyslexia, Acquired, Brain Injuries, Cerebrovascular Accident
Status
Completed
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
Cognitive Therapy to Improve Reading
Sponsored by
About this trial
This is an interventional treatment trial for Dyslexia, Acquired focused on measuring Cognitive therapy, Aphasia therapy, Alexia, Acquired dyslexia, Phonological deficits, Orthographic deficits, Brain disorders, Brain injury, Stroke
Eligibility Criteria
Inclusion Criteria Reading deficit subsequent to stroke, traumatic brain injury, brain surgery, or other brain damage Ability to attend 2-3 sessions per week for several months at Georgetown University in Washington, DC Exclusion Criteria History of developmental dyslexia or learning disabilities Best corrected vision less than 20/40 Less than 10 years of formal education Significant memory or comprehension problems
Sites / Locations
- Georgetown University Medical Center
Outcomes
Primary Outcome Measures
Improved accuracy and/or speed of reading individual words aloud.
Secondary Outcome Measures
Improved accuracy and/or speed of reading text aloud.
Full Information
NCT ID
NCT00064805
First Posted
July 14, 2003
Last Updated
August 13, 2014
Sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
1. Study Identification
Unique Protocol Identification Number
NCT00064805
Brief Title
Therapy for Reading Problems in Adults After Brain Injury
Official Title
Cognitively-based Treatments of Acquired Dyslexias
Study Type
Interventional
2. Study Status
Record Verification Date
April 2014
Overall Recruitment Status
Completed
Study Start Date
August 2002 (undefined)
Primary Completion Date
July 2007 (Actual)
Study Completion Date
July 2007 (Actual)
3. Sponsor/Collaborators
Name of the Sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
4. Oversight
5. Study Description
Brief Summary
Adults who sustain brain damage due to stroke, head injury, or traumatic surgery may develop difficulty reading. This study examines the effectiveness of behavior-based programs to improve reading ability in these individuals.
Detailed Description
Acquired disorders of reading (acquired dyslexia) are common in patients with aphasia subsequent to left hemisphere stroke. Even when language functions recover sufficiently to enable the patient to return to work, continuing dyslexia often interferes significantly with job performance. This study will evaluate cognitive therapies for the treatment of acquired dyslexia.
Each therapy is based upon a cognitive neuropsychological model of reading; the therapies target specific types of reading deficit and stem from the question of re-learning versus re-organization of function. The therapies focus on dyslexic disorders stemming from the following underlying deficits: 1) impaired access to the orthographic word form from the visual modality (pure alexia); 2) impaired orthographic/phonologic connections (phonologic/deep dyslexia); and 3) decreased ability to hold phonologic codes in memory (phonologic text alexia).
Participants in this study will undergo a comprehensive and detailed battery of reading and reading-related tests to determine the underlying impairment causing the reading deficit. Based upon the results of these tests, the patient's dyslexic disorder will be characterized and, if appropriate, the patient will be assigned to one of the treatment programs devised specifically for that type of deficit. Treatment programs are evaluated for efficacy by comparing the accuracy and speed of reading pre- and post-treatment.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Dyslexia, Acquired, Brain Injuries, Cerebrovascular Accident
Keywords
Cognitive therapy, Aphasia therapy, Alexia, Acquired dyslexia, Phonological deficits, Orthographic deficits, Brain disorders, Brain injury, Stroke
7. Study Design
Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Non-Randomized
Enrollment
58 (Anticipated)
8. Arms, Groups, and Interventions
Intervention Type
Behavioral
Intervention Name(s)
Cognitive Therapy to Improve Reading
Primary Outcome Measure Information:
Title
Improved accuracy and/or speed of reading individual words aloud.
Secondary Outcome Measure Information:
Title
Improved accuracy and/or speed of reading text aloud.
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria
Reading deficit subsequent to stroke, traumatic brain injury, brain surgery, or other brain damage
Ability to attend 2-3 sessions per week for several months at Georgetown University in Washington, DC
Exclusion Criteria
History of developmental dyslexia or learning disabilities
Best corrected vision less than 20/40
Less than 10 years of formal education
Significant memory or comprehension problems
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Rhonda B. Friedman, Ph.D.
Organizational Affiliation
Georgetown University Medical School
Official's Role
Principal Investigator
Facility Information:
Facility Name
Georgetown University Medical Center
City
Washington
State/Province
District of Columbia
ZIP/Postal Code
20057
Country
United States
12. IPD Sharing Statement
Citations:
PubMed Identifier
10764518
Citation
Friedman RB, Lott SN. Rapid word identification in pure alexia is lexical but not semantic. Brain Lang. 2000 May;72(3):219-37. doi: 10.1006/brln.2000.2286.
Results Reference
background
PubMed Identifier
10210630
Citation
Nitzberg Lott S, Friedman RB. Can treatment for pure alexia improve letter-by-letter reading speed without sacrificing accuracy? Brain Lang. 1999 May;67(3):188-201. doi: 10.1006/brln.1999.2054.
Results Reference
background
PubMed Identifier
11640944
Citation
Friedman RB, Sample DM, Lott SN. The role of level of representation in the use of paired associate learning for rehabilitation of alexia. Neuropsychologia. 2002;40(2):223-34. doi: 10.1016/s0028-3932(01)00098-7.
Results Reference
background
PubMed Identifier
15862852
Citation
Marchand Y, Friedman RB. Impaired oral reading in two atypical dyslexics: a comparison with a computational lexical-analogy model. Brain Lang. 2005 Jun;93(3):255-66. doi: 10.1016/j.bandl.2004.10.013. Epub 2004 Dec 15.
Results Reference
background
PubMed Identifier
18513760
Citation
Lott SN, Sample DM, Oliver RT, Lacey EH, Friedman RB. A patient with phonologic alexia can learn to read "much" from "mud pies". Neuropsychologia. 2008 Aug;46(10):2515-23. doi: 10.1016/j.neuropsychologia.2008.04.004. Epub 2008 Apr 16.
Results Reference
background
PubMed Identifier
21170161
Citation
Lott SN, Carney AS, Glezer LS, Friedman RB. Overt use of a tactile-kinesthetic strategy shifts to covert processing in rehabilitation of letter-by-letter reading. Aphasiology. 2010 Nov;24(11):1424-1442. doi: 10.1080/02687030903580333.
Results Reference
background
PubMed Identifier
20574915
Citation
Lacey EH, Lott SN, Snider SF, Sperling A, Friedman RB. Multiple Oral Re-reading treatment for alexia: The parts may be greater than the whole. Neuropsychol Rehabil. 2010 Aug;20(4):601-23. doi: 10.1080/09602011003710993. Epub 2010 Jul 6. Erratum In: Neuropsychol Rehabil. 2010 Dec;20(6):940.
Results Reference
background
PubMed Identifier
20119495
Citation
Kurland J, Cortes CR, Wilke M, Sperling AJ, Lott SN, Tagamets MA, Vanmeter J, Friedman RB. Neural Mechanisms Underlying Learning following Semantic Mediation Treatment in a case of Phonologic Alexia. Brain Imaging Behav. 2008 Sep;2(3):147. doi: 10.1007/s11682-008-9027-2.
Results Reference
background
Links:
URL
http://explore.georgetown.edu/people/friedmar/?PageTemplateID=212
Description
Cognitive Neuropsychology Lab at Georgetown University Medical Center
Learn more about this trial
Therapy for Reading Problems in Adults After Brain Injury
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