A Study of Physical and Metabolic Abnormalities in HIV Infected and Uninfected Children and Youth
HIV Infections, HIV-Associated Lipodystrophy Syndrome, HIV Lipodystrophy Syndrome
About this trial
This is an observational trial for HIV Infections focused on measuring HIV-Associated Lipodystrophy Syndrome, HIV Lipodystrophy Syndrome, Treatment Experienced, Lipodystrophy, Dyslipidemia, Osteoporosis, Osteopenia
Eligibility Criteria
Inclusion Criteria For HIV uninfected participants (Group 1) HIV-1 negative (perinatally HIV-exposed but uninfected participants are eligible) For HIV infected participants (Groups 2 and 3) Mother-to-child (vertically) transmitted HIV infection Confirmed diagnosis of HIV-1 infection by two positive assays from two different samples For Group 2, cannot have taken a PI-containing regimen in the 12 months prior to study entry or have ever received a PI for 2 or more weeks For Group 3, must currently be taking the same PI-containing regimen taken continuously for at least 12 months prior to study entry For all participants Accessible medical and medications history Parent, legal guardian, or participant willing to give informed consent and willing to comply with study requirements Females who have begun menstruating must have negative pregnancy test Exclusion Criteria Receipt of certain medications, including growth hormone, megestrol acetate, anabolic agents, anticytokine agents, systemic ketoconazole, systemic glucocorticoids (except if receiving stable physiologic doses), or drugs to treat osteoporosis Type II diabetes mellitus and unable to omit medication prior to specimen collection Pregnancy within the last 12 months, currently pregnant, or breastfeeding History of eating disorder
Sites / Locations
- UAB, Dept. of Ped., Div. of Infectious Diseases
- Usc La Nichd Crs
- Long Beach Memorial Med. Ctr., Miller Children's Hosp.
- UCSD Mother-Child-Adolescent Program CRS
- UCSF Pediatric AIDS CRS
- Harbor - UCLA Med. Ctr. - Dept. of Peds., Div. of Infectious Diseases
- Univ. of Colorado Denver NICHD CRS
- Yale Univ. School of Medicine - Dept. of Peds., Div. of Infectious Disease
- Children's National Med. Ctr., ACTU
- Howard Univ. Washington DC NICHD CRS
- South Florida CDTC Ft Lauderdale NICHD CRS
- Univ. of Florida College of Medicine-Dept of Peds, Div. of Immunology, Infectious Diseases & Allergy
- USF - Tampa NICHD CRS
- Med. College of Georgia School of Medicine, Dept. of Peds., Div. of Infectious Diseases
- Mt. Sinai Hosp. Med. Ctr. - Chicago, Womens & Childrens HIV Program
- Chicago Children's CRS
- Tulane/LSU Maternal/Child CRS
- Johns Hopkins Hosp. & Health System - Dept. of Peds., Div. of Infectious Diseases
- HMS - Children's Hosp. Boston, Div. of Infectious Diseases
- UMDNJ - Robert Wood Johnson Med. School, Div. of Allergy, Immunology & Infectious Diseases
- Rutgers - New Jersey Medical School CRS
- Lincoln Med. & Mental Health Ctr.
- Bronx-Lebanon Hosp. IMPAACT CRS
- Jacobi Med. Ctr.
- SUNY Downstate Med. Ctr., Children's Hosp. at Downstate NICHD CRS
- Nyu Ny Nichd Crs
- Metropolitan Hosp. Ctr.
- Mt. Sinai School of Medicine, Div. of Ped. Infectious Diseases
- Harlem Hosp. Ctr. NY NICHD CRS
- Strong Memorial Hospital Rochester NY NICHD CRS
- SUNY Stony Brook NICHD CRS
- SUNY Upstate Med. Univ., Dept. of Peds.
- UNC at Chapel Hill School of Medicine - Dept. of Peds., Div. of Immunology & Infectious Diseases
- DUMC Ped. CRS
- St. Jude/UTHSC CRS
- Texas Children's Hosp. CRS
- Univ. of Puerto Rico Ped. HIV/AIDS Research Program CRS
- San Juan City Hosp. PR NICHD CRS