Natural History of West Nile Virus Infection
West Nile Virus, Encephalitis, Myelitis
About this trial
This is an observational trial for West Nile Virus focused on measuring West Nile Virus, Encephalitis, Virus, Mosquito, Fever, WNV, Myelitis
Eligibility Criteria
INCLUSION CRITERIA: Patients, regardless of race or gender, who consent and meet entry criteria will be enrolled, according to the following criteria. Note: Due to the low case incidence and the lack of validation of the neurologic scoring systems in children, enrollment will be restricted to adults. Two cohorts of patients will be enrolled: Neuroinvasive Disease and West Nile Fever. Greater than or equal to 18 years of age. Documented WNV infection (fever or neuroinvasive disease) that began within four months prior to study entry. Illnesss onset is defined as the first visit to a medical care provider where compatible symptoms (see cohort A or B below) are documented. Local laboratory documentation of WNV infection as defined by positive IgM and/or PCR for WNV in serum or CSF concurrent with or following illness onset. Qualification for Cohort A or B: A. Neuroinvasive Disease Cohort: - Fever (temperature greater than 38 C) documented by a health care provider AND: at least one of the following, as documented by a health care provider and in the absence of a more likely clinical explanation: Acutely altered mental status (e.g., disorientation, obtundation, stupor, or coma), Other acute signs of central or peripheral neurologic dysfunction (e.g., paresis or paralysis, nerve palsies, sensory deficits, abnormal reflexes, generalized convulsions, or abnormal movements), or Cerebrospinal fluid (CSF) pleocytosis (white blood cell count greater than or equal to 4 per mm(3) corrected for red blood cell contamination in CSF) associated with illness clinically compatible with meningitis (e.g., headache or stiff neck) B. West Nile Fever Cohort: - Temperature greater than 38 C as documented by a health care provider. EXCLUSION CRITERIA: Unable to obtain valid informed consent. Alternate explanation (as determined by the investigator) for clinical findings (such as structural brain lesion, cerebrovascular accident, or other infectious disease). Evidence of a microbial organism demonstrable on gram or fungal stain of CSF within four months prior to study entry. Investigator's opinion that patient would be unable to adhere to protocol requirements.
Sites / Locations
- National Institutes of Health Clinical Center, 9000 Rockville Pike