Fludarabine and Busulfan Followed by Allogeneic Stem Cell Transplant in Treating Older Patients With Acute Myeloid Leukemia in First Complete Remission

Eligibility Criteria: Patients with acute myeloid leukemia (AML) (excluding French-American-British [FAB] classification system M3) who have achieved a first morphologic complete remission and who meet the criteria below; patients with preceding myelodysplastic syndrome (MDS) or treatment-related AML are eligible; patients with prior central nervous system (CNS) involvement are eligible as long as disease is in remission at transplant; patients with acute leukemia following blast transformation of prior chronic myeloid leukemia (CML) or other myeloproliferative disease are excluded Complete remission (CR) will be defined according to the revised recommendations of the International Working Group (24) as all of the following: Normal bone marrow morphology with < 5% blasts Absolute neutrophil count (ANC) > 1,000/uL, referring to the count needed to confirm that the patient achieved a CR Platelet count > 100,000/uL No extramedullary leukemia No blasts in peripheral blood CR was achieved after one or two (but no more than two) cycles of induction chemotherapy with standard cytotoxic chemotherapy (e.g., cytarabine and an anthracycline) or after no more than four cycles of a hypomethylating agent containing regimen including either 5-azacytidine or decitabine Patients may have received as many as but no more than two cycles of consolidation therapy prior to transplant; any consolidation regimen that does not require transplant can be used; no more than 6 months can elapse from documentation of morphologic CR to transplant; the platelet count does not need to be > 100,000/uL after consolidation, as long as the bone marrow assessment prior to transplant does not show relapse Identification of hematopoietic cell donor >= 4 weeks since prior chemotherapy, radiation therapy, and surgery Performance status 0-2 Diffusion capacity of carbon monoxide (DLCO) > 40% with no symptomatic pulmonary disease Left ventricular ejection fraction (LVEF) by multi gated acquisition scan (MUGA) or echocardiogram (ECHO) >= 30% No uncontrolled diabetes mellitus or active serious infection requiring antibiotics No known hypersensitivity to E. coli-derived products No human immunodeficiency virus (HIV) infection Calculated creatinine clearance >= 40 cc/min Bilirubin < 2 mg/dL * If bilirubin is 2-3 mg/dL, but direct bilirubin is normal then patient will be considered eligible Aspartate aminotransferase (AST) < 3 x upper limit of normal DONOR: HLA-identical sibling (6/6); the donor must be determined to be an human leukocyte antigen (HLA)-identical sibling (6/6) by serologic typing for class (A, B) and low resolution molecular typing for class II (DRB1) DONOR: Matched unrelated donor (10/10); high resolution molecular typing at the following loci is required: HLA-A, -B, -C, -DRB1, and -DQB1 DONOR: the donor must be healthy and must be an acceptable donor as per institutional standards for stem cell donation DONOR: the donor must have no significant cardiopulmonary, renal, endocrine, or hepatic disease DONOR: there is no donor age restriction if the donor is a matched sibling DONOR: syngeneic donors are not eligible