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Imatinib Mesylate or Dasatinib in Treating Patients With Previously Untreated Chronic Phase Chronic Myelogenous Leukemia

Primary Purpose

Chronic Myeloid Leukemia, BCR-ABL1 Positive

Status

Active

Phase

Phase 2

Locations

International

Study Type

Interventional

Intervention

Dasatinib

Imatinib Mesylate

Laboratory Biomarker Analysis

About this trial

This is an interventional treatment trial for Chronic Myeloid Leukemia, BCR-ABL1 Positive

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria: Patients must have CML in chronic phase based on bone marrow aspiration and biopsy and peripheral blood counts obtained within 28 days before registration Patients must be registered on this study within 180 days after the date of first being diagnosed with CML, based on a cytogenetic or molecular analysis of peripheral blood or bone marrow, demonstrating the presence of the Philadelphia chromosome or variants of the (9;22) translocation or testing positive for Bcr-Abl by real time-polymerase chain reaction (RT-PCR); patients may have secondary chromosomal abnormalities in addition to the Philadelphia chromosome and remain eligible Patients must have Zubrod performance status 0-2 Patients must not have received prior treatment for CML with the exception of hydroxyurea and/or anagrelide Patients must not have received any prior chemotherapy regimen for peripheral blood stem cell mobilization; (prior collection of unmobilized peripheral blood stem cells is permitted) Serum bilirubin =< 2.0 x the institutional upper limit of the normal (IULN) Serum glutamic oxaloacetic transaminase (SGOT)/aspartate aminotransferase (AST) or serum glutamate pyruvate transaminase (SGPT)/alanine transaminase (ALT) =< 2.0 x the IULN Patients (Southwestern Oncology Group [SWOG] institutions only) must be registered on SWOG-9007, "Cytogenetic Studies in Leukemia Patients;" collection of the pretreatment bone marrow specimen must be completed within 28 days prior to registration; the pretreatment bone marrow specimen must be submitted to an approved Southwest Oncology Group Cytogenetics Laboratory for cytogenetic analysis as described, and an aliquot of the bone marrow (or peripheral blood if the marrow aspiration is a dry tap) must be submitted for fluorescent in situ hybridization (FISH) analysis; note that protocol SWOG-9007 also requires submission of bone marrow specimens at the time of progression to the accelerated or blastic phase of CML or the loss of complete hematologic response and every six months while the patient is on this study Patients (SWOG institutions only) must be registered on S9910, "Leukemia Centralized Reference Laboratories and Tissue Repositories, Ancillary;" specimens of peripheral blood and bone marrow must be submitted to the Southwest Oncology Group Lymphoid Leukemia and CML Centralized Laboratory in Seattle, Washington; collection of pretreatment blood and marrow specimens must be completed within 28 days prior to registration; note that this study also requires submission of peripheral blood and bone marrow specimens at various times after entry into the study Patients must not have undergone major surgery within 28 days before registration, and must have fully recovered from any other prior major surgery Patients must not be pregnant or nursing; women/men of reproductive potential must have agreed to use an effective contraceptive method No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, cervical carcinoma in situ, adequately treated stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease-free for five years Patients must have an electrocardiogram (ECG) within 42 days prior to registration, and must not have any of the following cardiac symptoms prior to entry on study: Uncontrolled angina, congestive heart failure or myocardial infarction (MI) within 6 months of study entry Diagnosed or suspected congenital long QT syndrome Any history of clinically significant ventricular arrhythmias (such as ventricular tachycardia, ventricular fibrillation, or Torsades de pointes) Prolonged corrected QT (QTc) interval on pre-entry electrocardiogram (> 450 msec) Uncontrolled hypertension Patients must not have a history of significant bleeding disorder unrelated to cancer, including: Congenital bleeding disorders (e.g., von Willebrand's disease) Acquired bleeding disorder within one year (e.g., acquired anti-factor VIII antibodies) All patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines At the time of patient registration, the treating institution's name and identification (ID) number must be provided to the Data Operations Center in Seattle in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered into the data base

Sites / Locations

Providence Saint Joseph Medical Center/Disney Family Cancer Center
City of Hope Comprehensive Cancer Center
Kaiser Permanente-Fremont
USC / Norris Comprehensive Cancer Center
Kaiser Permanente-Oakland
Kaiser Permanente-Redwood City
Kaiser Permanente-Richmond
Kaiser Permanente-Roseville
Kaiser Permanente-South Sacramento
Kaiser Permanente - Sacramento
Kaiser Permanente-San Francisco
Kaiser Permanente-Santa Teresa-San Jose
Kaiser Permanente San Leandro
Kaiser Permanente-San Rafael
Kaiser Permanente Medical Center - Santa Clara
Kaiser Permanente-Santa Rosa
Kaiser Permanente-South San Francisco
Kaiser Permanente-Stockton
Kaiser Permanente-Vallejo
Kaiser Permanente-Walnut Creek
Rocky Mountain Regional VA Medical Center
University of Colorado
Poudre Valley Hospital
Montrose Memorial Hospital
SCL Health Lutheran Medical Center
Beebe Medical Center
Christiana Care Health System-Christiana Hospital
Saint Francis Hospital - Wilmington
Baptist MD Anderson Cancer Center
Mayo Clinic in Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center
Orlando Health Cancer Institute
Moffitt Cancer Center
Saint Anthony's Health
Rush - Copley Medical Center
Saint Joseph Medical Center
Graham Hospital Association
Memorial Hospital
Hematology and Oncology Associates
Northwestern University
Jesse Brown Veterans Affairs Medical Center
University of Illinois
Mercy Hospital and Medical Center
Swedish Covenant Hospital
University of Chicago Comprehensive Cancer Center
Decatur Memorial Hospital
Heartland Cancer Research NCORP
Eureka Hospital
Galesburg Cottage Hospital
Illinois CancerCare-Galesburg
Western Illinois Cancer Treatment Center
Mason District Hospital
Hopedale Medical Complex - Hospital
Midwest Center for Hematology Oncology
Duly Health and Care Joliet
Kewanee Hospital
Deerpath Medical Associates
AMG Libertyville - Oncology
Mcdonough District Hospital
Loyola University Medical Center
Good Samaritan Regional Health Center
DuPage Medical Group-Ogden
Illinois Cancer Specialists-Niles
Bromenn Regional Medical Center
Carle Cancer Institute Normal
Illinois CancerCare-Ottawa Clinic
Ottawa Regional Hospital and Healthcare Center
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
Pekin Hospital
Proctor Hospital
Illinois CancerCare-Peoria
Methodist Medical Center of Illinois
OSF Saint Francis Medical Center
Illinois Valley Hospital
Valley Radiation Oncology
Perry Memorial Hospital
Swedish American Hospital
Edward H Kaplan MD and Associates
Hematology Oncology Associates of Illinois - Skokie
Midwest Cancer Research Group Incorporated
Saint Margaret's Hospital
Memorial Medical Center
Carle Cancer Center
Franciscan Saint Francis Health-Beech Grove
Fort Wayne Medical Oncology and Hematology Inc-Parkview
Franciscan Saint Anthony Health-Michigan City
Reid Health
McFarland Clinic - Ames
Memorial Hospital of Arkansas City
Cancer Center of Kansas - Chanute
Cancer Center of Kansas - Dodge City
Cancer Center of Kansas - El Dorado
Cancer Center of Kansas-Independence
Providence Medical Center
Cancer Center of Kansas-Kingman
Lawrence Memorial Hospital
Southwest Medical Center
Cancer Center of Kansas - Newton
Cancer Center of Kansas - Ottawa
Menorah Medical Center
Radiation Oncology Practice Corporation Southwest
Cancer Center of Kansas - Parsons
Kansas City NCI Community Oncology Research Program
Cancer Center of Kansas - Pratt
Cancer Center of Kansas - Salina
Salina Regional Health Center
Advent Health - Shawnee Mission Medical Center
Cotton O'Neil Cancer Center / Stormont Vail Health
University of Kansas Health System Saint Francis Campus
Cancer Center of Kansas - Wellington
Associates In Womens Health
Cancer Center of Kansas-Wichita Medical Arts Tower
Ascension Via Christi Hospitals Wichita
Cancer Center of Kansas - Wichita
Wichita NCI Community Oncology Research Program
Cancer Center of Kansas - Winfield
Baton Rouge General Medical Center
Mary Bird Perkins Cancer Center
Louisiana State University Health Science Center
University Medical Center New Orleans
Eastern Maine Medical Center
York Hospital
Christiana Care - Union Hospital
Unspecified Site
Massachusetts General Hospital Cancer Center
Brigham and Women's Hospital
Dana-Farber Cancer Institute
Michigan Cancer Research Consortium NCORP
Saint Joseph Mercy Hospital
University of Michigan Comprehensive Cancer Center
Bronson Battle Creek
Spectrum Health Big Rapids Hospital
Beaumont Hospital - Dearborn
Henry Ford Hospital
Ascension Saint John Hospital
Hurley Medical Center
Genesys Regional Medical Center-West Flint Campus
Cancer Research Consortium of West Michigan NCORP
Spectrum Health at Butterworth Campus
Trinity Health Grand Rapids Hospital
Holland Community Hospital
Allegiance Health
Bronson Methodist Hospital
West Michigan Cancer Center
Borgess Medical Center
Sparrow Hospital
Trinity Health Saint Mary Mercy Livonia Hospital
Mercy Health Partners-Hackley Campus
McLaren Cancer Institute-Northern Michigan
Saint Joseph Mercy Oakland
Lake Huron Medical Center
Ascension Saint Mary's Hospital
Ascension Providence Hospitals - Southfield
Munson Medical Center
Saint John Macomb-Oakland Hospital
University of Michigan Health - West
Fairview Ridges Hospital
Mercy Hospital
Fairview Southdale Hospital
Unity Hospital
Hutchinson Area Health Care
Meeker County Memorial Hospital
Minnesota Oncology Hematology PA-Maplewood
Saint John's Hospital - Healtheast
Abbott-Northwestern Hospital
Virginia Piper Cancer Institute
Hennepin County Medical Center
North Memorial Medical Health Center
Mayo Clinic in Rochester
Metro Minnesota Community Oncology Research Consortium
Park Nicollet Clinic - Saint Louis Park
Regions Hospital
Saint Joseph's Hospital - Healtheast
United Hospital
Saint Francis Regional Medical Center
Ridgeview Medical Center
Minnesota Oncology Hematology PA-Woodbury
Woodwinds Health Campus
Singing River Hospital
Southeast Missouri Hospital
Saint Francis Medical Center
Missouri Cancer Associates
Centerpoint Medical Center LLC
Truman Medical Centers
Saint Luke's Hospital of Kansas City
Radiation Oncology Practice Corporation South
Saint Joseph Health Center
North Kansas City Hospital
Research Medical Center
Radiation Oncology Practice Corporation - North
Liberty Radiation Oncology Center
Heartland Regional Medical Center
SSM Health Saint Louis University Hospital
Saint Louis Cancer and Breast Institute-South City
Mercy Hospital Saint Louis
Saint Louis-Cape Girardeau CCOP
Billings Clinic Cancer Center
Northern Rockies Radiation Oncology Center
Saint Vincent Healthcare
Montana Cancer Consortium NCORP
Saint Vincent Frontier Cancer Center
Deaconess Medical Center
Bozeman Deaconess Hospital
Internal Medicine of Bozeman
Saint James Community Hospital and Cancer Treatment Center
Benefis Healthcare- Sletten Cancer Institute
Berdeaux, Donald MD (UIA Investigator)
Great Falls Clinic
Saint Peter's Community Hospital
Glacier Oncology PLLC
Kalispell Medical Oncology
Kalispell Regional Medical Center
Eastern Montana Cancer Center
Montana Cancer Specialists
Saint Patrick Hospital - Community Hospital
Community Medical Hospital
Guardian Oncology and Center for Wellness
Cooper Hospital University Medical Center
Riverview Medical Center/Booker Cancer Center
University of New Mexico Cancer Center
Montefiore Medical Center-Wakefield Campus
Mary Imogene Bassett Hospital
Hematology Oncology Associates of Central New York-East Syracuse
Adirondack Cancer Center
Glens Falls Hospital
Interlakes Foundation Inc-Rochester
University of Rochester
Stony Brook University Medical Center
State University of New York Upstate Medical University
Syracuse Veterans Administration Medical Center
Carolinas Medical Center/Levine Cancer Institute
Wayne Memorial Hospital
Wayne Radiation Oncology
Lenoir Memorial Hospital
Vidant Oncology-Kinston
Rutherford Hospital
Iredell Memorial Hospital
Wilson Medical Center
Southeast Clinical Oncology Research Consortium NCORP
Wake Forest University Health Sciences
Mary Rutan Hospital
Aultman Health Foundation
Adena Regional Medical Center
University of Cincinnati Cancer Center-UC Medical Center
Ohio State University Comprehensive Cancer Center
Riverside Methodist Hospital
Columbus NCI Community Oncology Research Program
Grant Medical Center
Mount Carmel Health Center West
Doctors Hospital
Grandview Hospital
Good Samaritan Hospital - Dayton
Miami Valley Hospital
Miami Valley Hospital North
Dayton Veterans Affairs Medical Center
Dayton NCI Community Oncology Research Program
Grady Memorial Hospital
Blanchard Valley Hospital
Atrium Medical Center-Middletown Regional Hospital
Kettering Medical Center
Fairfield Medical Center
Saint Rita's Medical Center
OhioHealth Mansfield Hospital
Marietta Memorial Hospital
Licking Memorial Hospital
Springfield Regional Medical Center
Upper Valley Medical Center
Saint Ann's Hospital
Wright-Patterson Medical Center
Greene Memorial Hospital
Tod Children's Hospital - Forum Health
Genesis Healthcare System Cancer Care Center
Natalie Warren Bryant Cancer Center at Saint Francis
Kaiser Permanente Northwest
Oregon Health and Science University
Saint Luke's University Hospital-Bethlehem Campus
Geisinger Medical Center
Penn State Milton S Hershey Medical Center
Lewistown Hospital
Jefferson Torresdale Hospital
West Penn Hospital
Geisinger Medical Group
Mount Nittany Medical Center
Geisinger Wyoming Valley/Henry Cancer Center
AnMed Health Hospital
Medical University of South Carolina
McLeod Regional Medical Center
Spartanburg Medical Center
Sanford Cancer Center Oncology Clinic
Avera Cancer Institute
Medical X-Ray Center
Avera McKennan Hospital and University Health Center
Sanford USD Medical Center - Sioux Falls
Brooke Army Medical Center
Wilford Hall Medical Center
Audie L Murphy VA Hospital
Cancer Therapy and Research Center at The UT Health Science Center at San Antonio
University Hospital
University of Texas Health Science Center at San Antonio
Huntsman Cancer Institute/University of Utah
PeaceHealth Saint Joseph Medical Center
Harrison HealthPartners Hematology and Oncology-Bremerton
Kadlec Clinic Hematology and Oncology
Skagit Valley Hospital
Harborview Medical Center
Minor and James Medical PLLC
Fred Hutchinson Cancer Research Center
Kaiser Permanente Washington
Swedish Medical Center-First Hill
University of Washington Medical Center - Montlake
PeaceHealth United General Medical Center
Cancer Care Northwest - Spokane South
PeaceHealth Southwest Medical Center
Central Washington Hospital
Wenatchee Valley Hospital and Clinics
West Virginia University Healthcare
HSHS Sacred Heart Hospital
Marshfield Clinic Cancer Center at Sacred Heart
Gundersen Lutheran Medical Center
Marshfield Medical Center-Marshfield
Marshfield Medical Center
Medical College of Wisconsin
Marshfield Clinic-Minocqua Center
Ascension Saint Mary's Hospital
Marshfield Medical Center-Rice Lake
Ascension Saint Michael's Hospital
Marshfield Clinic-Wausau Center
Marshfield Medical Center - Weston
Marshfield Clinic - Wisconsin Rapids Center
Welch Cancer Center
Cross Cancer Institute
CancerCare Manitoba
The Moncton Hospital
Doctor H. Bliss Murphy Cancer Centre
QEII Health Sciences Centre/Nova Scotia Health Authority
Juravinski Cancer Centre at Hamilton Health Sciences
London Regional Cancer Program
University Health Network-Princess Margaret Hospital
Verdun Hospital Centre
Allan Blair Cancer Centre
Saskatoon Cancer Centre

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Arm Label

Arm I (QD imatinib mesylate)

Arm II (BID imatinib mesylate)

Arm III (dasatinib)

Arm Description

Patients receive imatinib mesylate PO QD. Treatment repeats every 4 weeks for up to 5 years in the absence of disease progression or unacceptable toxicity.

Patients receive imatinib mesylate PO BID. Treatment repeats every 4 weeks for up to 12 months in the absence of disease progression or unacceptable toxicity.

Patients receive dasatinib PO BID. Treatment repeats every 4 weeks for up to 5 years in the absence of disease progression or unacceptable toxicity.

Outcomes

Primary Outcome Measures

Molecular Response Rate at 12 Months

Median value of baseline bcr-abl/bcr ratio from pretreatment was used as the baseline value for assessing each patient's molecular response. Molecular response criteria were: 1) not failed treatment on or before 12-month evaluation; 2) met criteria for hemalotogic response; 3) bcr-abl/bcr ration at 12-months must be 10,000 times smaller than the pretreatment ratio.

Secondary Outcome Measures

Hematologic Response

Hematologic response assesses whether patients' blood counts return to normal

2-year Overall Survival (OS)

Overall survival was measured from the date of registration to study until death from any cause with observations censored at the date of last contact for patients last known to be alive.

Two Year Relapse-free Survival

Relapse-free survival is measured from the date of documented (possibly unconfirmed) hematologic complete remission until loss of hematologic complete remission or death from any cause. Observations are censored at the date of last contact for patients last known to be alive with report of loss of hematologic complete remission.

Toxicity

Number of patients with Grade 3-5 adverse events that are related to study drug by given type of adverse event

Full Information

NCT ID

NCT00070499

First Posted

October 3, 2003

Last Updated

August 24, 2023

Sponsor

National Cancer Institute (NCI)

1. Study Identification

Unique Protocol Identification Number

NCT00070499

Brief Title

Imatinib Mesylate or Dasatinib in Treating Patients With Previously Untreated Chronic Phase Chronic Myelogenous Leukemia

Official Title

A Phase IIb Study of Molecular Responses to Imatinib, at Standard or Increased Doses, or Dasatinib (BMS-354825) (NSC-732517) for Previously Untreated Patients With Chronic Myelogenous Leukemia (CML) in Chronic Phase

Study Type

Interventional

2. Study Status

Record Verification Date

August 2023

Overall Recruitment Status

Active, not recruiting

Study Start Date

August 15, 2004 (Actual)

Primary Completion Date

November 1, 2010 (Actual)

Study Completion Date

undefined (undefined)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

National Cancer Institute (NCI)

4. Oversight

Data Monitoring Committee

Yes

5. Study Description

Brief Summary

This randomized phase IIB trial studies imatinib mesylate at two different doses and dasatinib to see how well they work in treating patients with previously untreated chronic phase chronic myelogenous leukemia. Imatinib mesylate or dasatinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.

Detailed Description

PRIMARY OBJECTIVES: I. To compare the molecular response rates, as measured by the decrease in breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 (BCR-ABL) transcripts after 12 months of treatment, in patients with previously untreated chronic myelogenous leukemia (CML) in chronic phase who are treated with either dasatinib 100 mg/day or imatinib (STI571, Gleevec) (imatinib mesylate) 400 mg/day. II. To test whether increasing the dose of imatinib (STI571, Gleevec®) from 400 mg/day to 800 mg/day increases the rate of molecular response, as measured by the decrease in BCR-ABL transcripts after 12 months of treatment, in patients with previously untreated CML in chronic phase. III. To estimate rates of cytogenetic and hematologic responses to imatinib 400 mg/day, imatinib 800 mg/day, and dasatinib 100 mg/day. IV. To evaluate in a preliminary manner the prognostic effects of derivative (der)(9) and der(22) chromosomal deletions for response in CML patients treated with imatinib and dasatinib. V. To investigate in a preliminary manner changes in gene expression at relapse or progression compared to pre-treatment. VI. To estimate the frequency and severity of toxicities of the three treatment regimens. VII. To evaluate, in a preliminary manner, the overall survival and relapse-free survival of patients treated with these regimens. OUTLINE: Patients are randomized to 1 of 3 treatment arms. ARM I: Patients receive imatinib mesylate orally (PO) once daily (QD). Treatment repeats every 4 weeks for up to 5 years in the absence of disease progression or unacceptable toxicity. ARM II: Patients receive imatinib mesylate PO twice daily (BID). Treatment repeats every 4 weeks for up to 12 months in the absence of disease progression or unacceptable toxicity. ARM III: Patients receive dasatinib PO BID. Treatment repeats every 4 weeks for up to 5 years in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up for 15 years.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Chronic Myeloid Leukemia, BCR-ABL1 Positive

7. Study Design

Primary Purpose

Treatment

Study Phase

Phase 2

Interventional Study Model

Parallel Assignment

Masking

None (Open Label)

Allocation

Randomized

Enrollment

406 (Actual)

8. Arms, Groups, and Interventions

Arm Title

Arm I (QD imatinib mesylate)

Arm Type

Experimental

Arm Description

Patients receive imatinib mesylate PO QD. Treatment repeats every 4 weeks for up to 5 years in the absence of disease progression or unacceptable toxicity.

Arm Title

Arm II (BID imatinib mesylate)

Arm Type

Experimental

Arm Description

Patients receive imatinib mesylate PO BID. Treatment repeats every 4 weeks for up to 12 months in the absence of disease progression or unacceptable toxicity.

Arm Title

Arm III (dasatinib)

Arm Type

Experimental

Arm Description

Patients receive dasatinib PO BID. Treatment repeats every 4 weeks for up to 5 years in the absence of disease progression or unacceptable toxicity.

Intervention Type

Drug

Intervention Name(s)

Dasatinib

Other Intervention Name(s)

BMS-354825, Dasatinib Hydrate, Dasatinib Monohydrate, Sprycel

Intervention Description

Given PO

Intervention Type

Drug

Intervention Name(s)

Imatinib Mesylate

Other Intervention Name(s)

CGP 57148, CGP57148B, Gleevec, Glivec, STI 571, STI-571, STI571

Intervention Description

Given PO

Intervention Type

Other

Intervention Name(s)

Laboratory Biomarker Analysis

Intervention Description

Correlative studies

Primary Outcome Measure Information:

Title

Molecular Response Rate at 12 Months

Description

Time Frame

pretreatment and after 12 months of treatment

Secondary Outcome Measure Information:

Title

Hematologic Response

Description

Hematologic response assesses whether patients' blood counts return to normal

Time Frame

1 month after starting treatment

Title

2-year Overall Survival (OS)

Description

Overall survival was measured from the date of registration to study until death from any cause with observations censored at the date of last contact for patients last known to be alive.

Time Frame

Every three months for the first year, every six months in years 2 and 3, and annually for years 4 and 5

Title

Two Year Relapse-free Survival

Description

Time Frame

every 3 months for the first year, every six months for years 2 and 3, annually for years 4 and 5

Title

Toxicity

Description

Number of patients with Grade 3-5 adverse events that are related to study drug by given type of adverse event

Time Frame

Patients were assessed for adverse events monthly every 4 weeks for the first year, every 6 months for years 2 and 3, and annually for years 4 and 5.

10. Eligibility

Sex

All

Minimum Age & Unit of Time

18 Years

Accepts Healthy Volunteers

Eligibility Criteria

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Brian J Druker

Organizational Affiliation

SWOG Cancer Research Network

Official's Role

Principal Investigator

Facility Information:

Facility Name

Providence Saint Joseph Medical Center/Disney Family Cancer Center

City

Burbank

State/Province

California

ZIP/Postal Code

91505

Country

United States

Facility Name

City of Hope Comprehensive Cancer Center

City

Duarte

State/Province

California

ZIP/Postal Code

91010

Country

United States

Facility Name

Kaiser Permanente-Fremont

City

Fremont

State/Province

California

ZIP/Postal Code

94538

Country

United States

Facility Name

USC / Norris Comprehensive Cancer Center

City

Los Angeles

State/Province

California

ZIP/Postal Code

90033

Country

United States

Facility Name

Kaiser Permanente-Oakland

City

Oakland

State/Province

California

ZIP/Postal Code

94611

Country

United States

Facility Name

Kaiser Permanente-Redwood City

City

Redwood City

State/Province

California

ZIP/Postal Code

94063

Country

United States

Facility Name

Kaiser Permanente-Richmond

City

Richmond

State/Province

California

ZIP/Postal Code

94801

Country

United States

Facility Name

Kaiser Permanente-Roseville

City

Roseville

State/Province

California

ZIP/Postal Code

95661

Country

United States

Facility Name

Kaiser Permanente-South Sacramento

City

Sacramento

State/Province

California

ZIP/Postal Code

95823

Country

United States

Facility Name

Kaiser Permanente - Sacramento

City

Sacramento

State/Province

California

ZIP/Postal Code

95825

Country

United States

Facility Name

Kaiser Permanente-San Francisco

City

San Francisco

State/Province

California

ZIP/Postal Code

94115

Country

United States

Facility Name

Kaiser Permanente-Santa Teresa-San Jose

City

San Jose

State/Province

California

ZIP/Postal Code

95119

Country

United States

Facility Name

Kaiser Permanente San Leandro

City

San Leandro

State/Province

California

ZIP/Postal Code

94577

Country

United States

Facility Name

Kaiser Permanente-San Rafael

City

San Rafael

State/Province

California

ZIP/Postal Code

94903

Country

United States

Facility Name

Kaiser Permanente Medical Center - Santa Clara

City

Santa Clara

State/Province

California

ZIP/Postal Code

95051

Country

United States

Facility Name

Kaiser Permanente-Santa Rosa

City

Santa Rosa

State/Province

California

ZIP/Postal Code

95403

Country

United States

Facility Name

Kaiser Permanente-South San Francisco

City

South San Francisco

State/Province

California

ZIP/Postal Code

94080

Country

United States

Facility Name

Kaiser Permanente-Stockton

City

Stockton

State/Province

California

ZIP/Postal Code

95210

Country

United States

Facility Name

Kaiser Permanente-Vallejo

City

Vallejo

State/Province

California

ZIP/Postal Code

94589

Country

United States

Facility Name

Kaiser Permanente-Walnut Creek

City

Walnut Creek

State/Province

California

ZIP/Postal Code

94596

Country

United States

Facility Name

Rocky Mountain Regional VA Medical Center

City

Aurora

State/Province

Colorado

ZIP/Postal Code

80045

Country

United States

Facility Name

University of Colorado

City

Denver

State/Province

Colorado

ZIP/Postal Code

80217-3364

Country

United States

Facility Name

Poudre Valley Hospital

City

Fort Collins

State/Province

Colorado

ZIP/Postal Code

80524

Country

United States

Facility Name

Montrose Memorial Hospital

City

Montrose

State/Province

Colorado

ZIP/Postal Code

81401

Country

United States

Facility Name

SCL Health Lutheran Medical Center

City

Wheat Ridge

State/Province

Colorado

ZIP/Postal Code

80033

Country

United States

Facility Name

Beebe Medical Center

City

Lewes

State/Province

Delaware

ZIP/Postal Code

19958

Country

United States

Facility Name

Christiana Care Health System-Christiana Hospital

City

Newark

State/Province

Delaware

ZIP/Postal Code

19718

Country

United States

Facility Name

Saint Francis Hospital - Wilmington

City

Wilmington

State/Province

Delaware

ZIP/Postal Code

19805

Country

United States

Facility Name

Baptist MD Anderson Cancer Center

City

Jacksonville

State/Province

Florida

ZIP/Postal Code

32207

Country

United States

Facility Name

Mayo Clinic in Florida

City

Jacksonville

State/Province

Florida

ZIP/Postal Code

32224-9980

Country

United States

Facility Name

University of Miami Miller School of Medicine-Sylvester Cancer Center

City

Miami

State/Province

Florida

ZIP/Postal Code

33136

Country

United States

Facility Name

Orlando Health Cancer Institute

City

Orlando

State/Province

Florida

ZIP/Postal Code

32806

Country

United States

Facility Name

Moffitt Cancer Center

City

Tampa

State/Province

Florida

ZIP/Postal Code

33612

Country

United States

Facility Name

Saint Anthony's Health

City

Alton

State/Province

Illinois

ZIP/Postal Code

62002

Country

United States

Facility Name

Rush - Copley Medical Center

City

Aurora

State/Province

Illinois

ZIP/Postal Code

60504

Country

United States

Facility Name

Saint Joseph Medical Center

City

Bloomington

State/Province

Illinois

ZIP/Postal Code

61701

Country

United States

Facility Name

Graham Hospital Association

City

Canton

State/Province

Illinois

ZIP/Postal Code

61520

Country

United States

Facility Name

Memorial Hospital

City

Carthage

State/Province

Illinois

ZIP/Postal Code

62321

Country

United States

Facility Name

Hematology and Oncology Associates

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60611

Country

United States

Facility Name

Northwestern University

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60611

Country

United States

Facility Name

Jesse Brown Veterans Affairs Medical Center

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60612

Country

United States

Facility Name

University of Illinois

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60612

Country

United States

Facility Name

Mercy Hospital and Medical Center

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60616

Country

United States

Facility Name

Swedish Covenant Hospital

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60625

Country

United States

Facility Name

University of Chicago Comprehensive Cancer Center

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60637

Country

United States

Facility Name

Decatur Memorial Hospital

City

Decatur

State/Province

Illinois

ZIP/Postal Code

62526

Country

United States

Facility Name

Heartland Cancer Research NCORP

City

Decatur

State/Province

Illinois

ZIP/Postal Code

62526

Country

United States

Facility Name

Eureka Hospital

City

Eureka

State/Province

Illinois

ZIP/Postal Code

61530

Country

United States

Facility Name

Galesburg Cottage Hospital

City

Galesburg

State/Province

Illinois

ZIP/Postal Code

61401

Country

United States

Facility Name

Illinois CancerCare-Galesburg

City

Galesburg

State/Province

Illinois

ZIP/Postal Code

61401

Country

United States

Facility Name

Western Illinois Cancer Treatment Center

City

Galesburg

State/Province

Illinois

ZIP/Postal Code

61401

Country

United States

Facility Name

Mason District Hospital

City

Havana

State/Province

Illinois

ZIP/Postal Code

62644

Country

United States

Facility Name

Hopedale Medical Complex - Hospital

City

Hopedale

State/Province

Illinois

ZIP/Postal Code

61747

Country

United States

Facility Name

Midwest Center for Hematology Oncology

City

Joliet

State/Province

Illinois

ZIP/Postal Code

60432

Country

United States

Facility Name

Duly Health and Care Joliet

City

Joliet

State/Province

Illinois

ZIP/Postal Code

60435

Country

United States

Facility Name

Kewanee Hospital

City

Kewanee

State/Province

Illinois

ZIP/Postal Code

61443

Country

United States

Facility Name

Deerpath Medical Associates

City

Lake Forest

State/Province

Illinois

ZIP/Postal Code

60045

Country

United States

Facility Name

AMG Libertyville - Oncology

City

Libertyville

State/Province

Illinois

ZIP/Postal Code

60048

Country

United States

Facility Name

Mcdonough District Hospital

City

Macomb

State/Province

Illinois

ZIP/Postal Code

61455

Country

United States

Facility Name

Loyola University Medical Center

City

Maywood

State/Province

Illinois

ZIP/Postal Code

60153

Country

United States

Facility Name

Good Samaritan Regional Health Center

City

Mount Vernon

State/Province

Illinois

ZIP/Postal Code

62864

Country

United States

Facility Name

DuPage Medical Group-Ogden

City

Naperville

State/Province

Illinois

ZIP/Postal Code

60563

Country

United States

Facility Name

Illinois Cancer Specialists-Niles

City

Niles

State/Province

Illinois

ZIP/Postal Code

60714

Country

United States

Facility Name

Bromenn Regional Medical Center

City

Normal

State/Province

Illinois

ZIP/Postal Code

61761

Country

United States

Facility Name

Carle Cancer Institute Normal

City

Normal

State/Province

Illinois

ZIP/Postal Code

61761

Country

United States

Facility Name

Illinois CancerCare-Ottawa Clinic

City

Ottawa

State/Province

Illinois

ZIP/Postal Code

61350

Country

United States

Facility Name

Ottawa Regional Hospital and Healthcare Center

City

Ottawa

State/Province

Illinois

ZIP/Postal Code

61350

Country

United States

Facility Name

OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center

City

Pekin

State/Province

Illinois

ZIP/Postal Code

61554

Country

United States

Facility Name

Pekin Hospital

City

Pekin

State/Province

Illinois

ZIP/Postal Code

61554

Country

United States

Facility Name

Proctor Hospital

City

Peoria

State/Province

Illinois

ZIP/Postal Code

61614

Country

United States

Facility Name

Illinois CancerCare-Peoria

City

Peoria

State/Province

Illinois

ZIP/Postal Code

61615

Country

United States

Facility Name

Methodist Medical Center of Illinois

City

Peoria

State/Province

Illinois

ZIP/Postal Code

61636

Country

United States

Facility Name

OSF Saint Francis Medical Center

City

Peoria

State/Province

Illinois

ZIP/Postal Code

61637

Country

United States

Facility Name

Illinois Valley Hospital

City

Peru

State/Province

Illinois

ZIP/Postal Code

61354

Country

United States

Facility Name

Valley Radiation Oncology

City

Peru

State/Province

Illinois

ZIP/Postal Code

61354

Country

United States

Facility Name

Perry Memorial Hospital

City

Princeton

State/Province

Illinois

ZIP/Postal Code

61356

Country

United States

Facility Name

Swedish American Hospital

City

Rockford

State/Province

Illinois

ZIP/Postal Code

61104

Country

United States

Facility Name

Edward H Kaplan MD and Associates

City

Skokie

State/Province

Illinois

ZIP/Postal Code

60076

Country

United States

Facility Name

Hematology Oncology Associates of Illinois - Skokie

City

Skokie

State/Province

Illinois

ZIP/Postal Code

60076

Country

United States

Facility Name

Midwest Cancer Research Group Incorporated

City

Skokie

State/Province

Illinois

ZIP/Postal Code

60077

Country

United States

Facility Name

Saint Margaret's Hospital

City

Spring Valley

State/Province

Illinois

ZIP/Postal Code

61362

Country

United States

Facility Name

Memorial Medical Center

City

Springfield

State/Province

Illinois

ZIP/Postal Code

62781

Country

United States

Facility Name

Carle Cancer Center

City

Urbana

State/Province

Illinois

ZIP/Postal Code

61801

Country

United States

Facility Name

Franciscan Saint Francis Health-Beech Grove

City

Beech Grove

State/Province

Indiana

ZIP/Postal Code

46107

Country

United States

Facility Name

Fort Wayne Medical Oncology and Hematology Inc-Parkview

City

Fort Wayne

State/Province

Indiana

ZIP/Postal Code

46845

Country

United States

Facility Name

Franciscan Saint Anthony Health-Michigan City

City

Michigan City

State/Province

Indiana

ZIP/Postal Code

46360

Country

United States

Facility Name

Reid Health

City

Richmond

State/Province

Indiana

ZIP/Postal Code

47374

Country

United States

Facility Name

McFarland Clinic - Ames

City

Ames

State/Province

Iowa

ZIP/Postal Code

50010

Country

United States

Facility Name

Memorial Hospital of Arkansas City

City

Arkansas City

State/Province

Kansas

ZIP/Postal Code

67005

Country

United States

Facility Name

Cancer Center of Kansas - Chanute

City

Chanute

State/Province

Kansas

ZIP/Postal Code

66720

Country

United States

Facility Name

Cancer Center of Kansas - Dodge City

City

Dodge City

State/Province

Kansas

ZIP/Postal Code

67801

Country

United States

Facility Name

Cancer Center of Kansas - El Dorado

City

El Dorado

State/Province

Kansas

ZIP/Postal Code

67042

Country

United States

Facility Name

Cancer Center of Kansas-Independence

City

Independence

State/Province

Kansas

ZIP/Postal Code

67301

Country

United States

Facility Name

Providence Medical Center

City

Kansas City

State/Province

Kansas

ZIP/Postal Code

66112

Country

United States

Facility Name

Cancer Center of Kansas-Kingman

City

Kingman

State/Province

Kansas

ZIP/Postal Code

67068

Country

United States

Facility Name

Lawrence Memorial Hospital

City

Lawrence

State/Province

Kansas

ZIP/Postal Code

66044

Country

United States

Facility Name

Southwest Medical Center

City

Liberal

State/Province

Kansas

ZIP/Postal Code

67901

Country

United States

Facility Name

Cancer Center of Kansas - Newton

City

Newton

State/Province

Kansas

ZIP/Postal Code

67114

Country

United States

Facility Name

Cancer Center of Kansas - Ottawa

City

Ottawa

State/Province

Kansas

ZIP/Postal Code

66067

Country

United States

Facility Name

Menorah Medical Center

City

Overland Park

State/Province

Kansas

ZIP/Postal Code

66209

Country

United States

Facility Name

Radiation Oncology Practice Corporation Southwest

City

Overland Park

State/Province

Kansas

ZIP/Postal Code

66210

Country

United States

Facility Name

Cancer Center of Kansas - Parsons

City

Parsons

State/Province

Kansas

ZIP/Postal Code

67357

Country

United States

Facility Name

Kansas City NCI Community Oncology Research Program

City

Prairie Village

State/Province

Kansas

ZIP/Postal Code

66208

Country

United States

Facility Name

Cancer Center of Kansas - Pratt

City

Pratt

State/Province

Kansas

ZIP/Postal Code

67124

Country

United States

Facility Name

Cancer Center of Kansas - Salina

City

Salina

State/Province

Kansas

ZIP/Postal Code

67401

Country

United States

Facility Name

Salina Regional Health Center

City

Salina

State/Province

Kansas

ZIP/Postal Code

67401

Country

United States

Facility Name

Advent Health - Shawnee Mission Medical Center

City

Shawnee Mission

State/Province

Kansas

ZIP/Postal Code

66204

Country

United States

Facility Name

Cotton O'Neil Cancer Center / Stormont Vail Health

City

Topeka

State/Province

Kansas

ZIP/Postal Code

66606

Country

United States

Facility Name

University of Kansas Health System Saint Francis Campus

City

Topeka

State/Province

Kansas

ZIP/Postal Code

66606

Country

United States

Facility Name

Cancer Center of Kansas - Wellington

City

Wellington

State/Province

Kansas

ZIP/Postal Code

67152

Country

United States

Facility Name

Associates In Womens Health

City

Wichita

State/Province

Kansas

ZIP/Postal Code

67208

Country

United States

Facility Name

Cancer Center of Kansas-Wichita Medical Arts Tower

City

Wichita

State/Province

Kansas

ZIP/Postal Code

67208

Country

United States

Facility Name

Ascension Via Christi Hospitals Wichita

City

Wichita

State/Province

Kansas

ZIP/Postal Code

67214

Country

United States

Facility Name

Cancer Center of Kansas - Wichita

City

Wichita

State/Province

Kansas

ZIP/Postal Code

67214

Country

United States

Facility Name

Wichita NCI Community Oncology Research Program

City

Wichita

State/Province

Kansas

ZIP/Postal Code

67214

Country

United States

Facility Name

Cancer Center of Kansas - Winfield

City

Winfield

State/Province

Kansas

ZIP/Postal Code

67156

Country

United States

Facility Name

Baton Rouge General Medical Center

City

Baton Rouge

State/Province

Louisiana

ZIP/Postal Code

70806

Country

United States

Facility Name

Mary Bird Perkins Cancer Center

City

Baton Rouge

State/Province

Louisiana

ZIP/Postal Code

70809

Country

United States

Facility Name

Louisiana State University Health Science Center

City

New Orleans

State/Province

Louisiana

ZIP/Postal Code

70112

Country

United States

Facility Name

University Medical Center New Orleans

City

New Orleans

State/Province

Louisiana

ZIP/Postal Code

70112

Country

United States

Facility Name

Eastern Maine Medical Center

City

Bangor

State/Province

Maine

ZIP/Postal Code

04401

Country

United States

Facility Name

York Hospital

City

York

State/Province

Maine

ZIP/Postal Code

03909

Country

United States

Facility Name

Christiana Care - Union Hospital

City

Elkton

State/Province

Maryland

ZIP/Postal Code

21921

Country

United States

Facility Name

Unspecified Site

City

Rockville

State/Province

Maryland

ZIP/Postal Code

20852

Country

United States

Facility Name

Massachusetts General Hospital Cancer Center

City

Boston

State/Province

Massachusetts

ZIP/Postal Code

02114

Country

United States

Facility Name

Brigham and Women's Hospital

City

Boston

State/Province

Massachusetts

ZIP/Postal Code

02115

Country

United States

Facility Name

Dana-Farber Cancer Institute

City

Boston

State/Province

Massachusetts

ZIP/Postal Code

02215

Country

United States

Facility Name

Michigan Cancer Research Consortium NCORP

City

Ann Arbor

State/Province

Michigan

ZIP/Postal Code

48106

Country

United States

Facility Name

Saint Joseph Mercy Hospital

City

Ann Arbor

State/Province

Michigan

ZIP/Postal Code

48106

Country

United States

Facility Name

University of Michigan Comprehensive Cancer Center

City

Ann Arbor

State/Province

Michigan

ZIP/Postal Code

48109

Country

United States

Facility Name

Bronson Battle Creek

City

Battle Creek

State/Province

Michigan

ZIP/Postal Code

49017

Country

United States

Facility Name

Spectrum Health Big Rapids Hospital

City

Big Rapids

State/Province

Michigan

ZIP/Postal Code

49307

Country

United States

Facility Name

Beaumont Hospital - Dearborn

City

Dearborn

State/Province

Michigan

ZIP/Postal Code

48124

Country

United States

Facility Name

Henry Ford Hospital

City

Detroit

State/Province

Michigan

ZIP/Postal Code

48202

Country

United States

Facility Name

Ascension Saint John Hospital

City

Detroit

State/Province

Michigan

ZIP/Postal Code

48236

Country

United States

Facility Name

Hurley Medical Center

City

Flint

State/Province

Michigan

ZIP/Postal Code

48503

Country

United States

Facility Name

Genesys Regional Medical Center-West Flint Campus

City

Flint

State/Province

Michigan

ZIP/Postal Code

48532

Country

United States

Facility Name

Cancer Research Consortium of West Michigan NCORP

City

Grand Rapids

State/Province

Michigan

ZIP/Postal Code

49503

Country

United States

Facility Name

Spectrum Health at Butterworth Campus

City

Grand Rapids

State/Province

Michigan

ZIP/Postal Code

49503

Country

United States

Facility Name

Trinity Health Grand Rapids Hospital

City

Grand Rapids

State/Province

Michigan

ZIP/Postal Code

49503

Country

United States

Facility Name

Holland Community Hospital

City

Holland

State/Province

Michigan

ZIP/Postal Code

49423

Country

United States

Facility Name

Allegiance Health

City

Jackson

State/Province

Michigan

ZIP/Postal Code

49201

Country

United States

Facility Name

Bronson Methodist Hospital

City

Kalamazoo

State/Province

Michigan

ZIP/Postal Code

49007

Country

United States

Facility Name

West Michigan Cancer Center

City

Kalamazoo

State/Province

Michigan

ZIP/Postal Code

49007

Country

United States

Facility Name

Borgess Medical Center

City

Kalamazoo

State/Province

Michigan

ZIP/Postal Code

49048

Country

United States

Facility Name

Sparrow Hospital

City

Lansing

State/Province

Michigan

ZIP/Postal Code

48912

Country

United States

Facility Name

Trinity Health Saint Mary Mercy Livonia Hospital

City

Livonia

State/Province

Michigan

ZIP/Postal Code

48154

Country

United States

Facility Name

Mercy Health Partners-Hackley Campus

City

Muskegon

State/Province

Michigan

ZIP/Postal Code

49442

Country

United States

Facility Name

McLaren Cancer Institute-Northern Michigan

City

Petoskey

State/Province

Michigan

ZIP/Postal Code

49770

Country

United States

Facility Name

Saint Joseph Mercy Oakland

City

Pontiac

State/Province

Michigan

ZIP/Postal Code

48341

Country

United States

Facility Name

Lake Huron Medical Center

City

Port Huron

State/Province

Michigan

ZIP/Postal Code

48060

Country

United States

Facility Name

Ascension Saint Mary's Hospital

City

Saginaw

State/Province

Michigan

ZIP/Postal Code

48601

Country

United States

Facility Name

Ascension Providence Hospitals - Southfield

City

Southfield

State/Province

Michigan

ZIP/Postal Code

48075

Country

United States

Facility Name

Munson Medical Center

City

Traverse City

State/Province

Michigan

ZIP/Postal Code

49684

Country

United States

Facility Name

Saint John Macomb-Oakland Hospital

City

Warren

State/Province

Michigan

ZIP/Postal Code

48093

Country

United States

Facility Name

University of Michigan Health - West

City

Wyoming

State/Province

Michigan

ZIP/Postal Code

49519

Country

United States

Facility Name

Fairview Ridges Hospital

City

Burnsville

State/Province

Minnesota

ZIP/Postal Code

55337

Country

United States

Facility Name

Mercy Hospital

City

Coon Rapids

State/Province

Minnesota

ZIP/Postal Code

55433

Country

United States

Facility Name

Fairview Southdale Hospital

City

Edina

State/Province

Minnesota

ZIP/Postal Code

55435

Country

United States

Facility Name

Unity Hospital

City

Fridley

State/Province

Minnesota

ZIP/Postal Code

55432

Country

United States

Facility Name

Hutchinson Area Health Care

City

Hutchinson

State/Province

Minnesota

ZIP/Postal Code

55350

Country

United States

Facility Name

Meeker County Memorial Hospital

City

Litchfield

State/Province

Minnesota

ZIP/Postal Code

55355

Country

United States

Facility Name

Minnesota Oncology Hematology PA-Maplewood

City

Maplewood

State/Province

Minnesota

ZIP/Postal Code

55109

Country

United States

Facility Name

Saint John's Hospital - Healtheast

City

Maplewood

State/Province

Minnesota

ZIP/Postal Code

55109

Country

United States

Facility Name

Abbott-Northwestern Hospital

City

Minneapolis

State/Province

Minnesota

ZIP/Postal Code

55407

Country

United States

Facility Name

Virginia Piper Cancer Institute

City

Minneapolis

State/Province

Minnesota

ZIP/Postal Code

55407

Country

United States

Facility Name

Hennepin County Medical Center

City

Minneapolis

State/Province

Minnesota

ZIP/Postal Code

55415

Country

United States

Facility Name

North Memorial Medical Health Center

City

Robbinsdale

State/Province

Minnesota

ZIP/Postal Code

55422

Country

United States

Facility Name

Mayo Clinic in Rochester

City

Rochester

State/Province

Minnesota

ZIP/Postal Code

55905

Country

United States

Facility Name

Metro Minnesota Community Oncology Research Consortium

City

Saint Louis Park

State/Province

Minnesota

ZIP/Postal Code

55416

Country

United States

Facility Name

Park Nicollet Clinic - Saint Louis Park

City

Saint Louis Park

State/Province

Minnesota

ZIP/Postal Code

55416

Country

United States

Facility Name

Regions Hospital

City

Saint Paul

State/Province

Minnesota

ZIP/Postal Code

55101

Country

United States

Facility Name

Saint Joseph's Hospital - Healtheast

City

Saint Paul

State/Province

Minnesota

ZIP/Postal Code

55102

Country

United States

Facility Name

United Hospital

City

Saint Paul

State/Province

Minnesota

ZIP/Postal Code

55102

Country

United States

Facility Name

Saint Francis Regional Medical Center

City

Shakopee

State/Province

Minnesota

ZIP/Postal Code

55379

Country

United States

Facility Name

Ridgeview Medical Center

City

Waconia

State/Province

Minnesota

ZIP/Postal Code

55387

Country

United States

Facility Name

Minnesota Oncology Hematology PA-Woodbury

City

Woodbury

State/Province

Minnesota

ZIP/Postal Code

55125

Country

United States

Facility Name

Woodwinds Health Campus

City

Woodbury

State/Province

Minnesota

ZIP/Postal Code

55125

Country

United States

Facility Name

Singing River Hospital

City

Pascagoula

State/Province

Mississippi

ZIP/Postal Code

39581

Country

United States

Facility Name

Southeast Missouri Hospital

City

Cape Girardeau

State/Province

Missouri

ZIP/Postal Code

63701

Country

United States

Facility Name

Saint Francis Medical Center

City

Cape Girardeau

State/Province

Missouri

ZIP/Postal Code

63703

Country

United States

Facility Name

Missouri Cancer Associates

City

Columbia

State/Province

Missouri

ZIP/Postal Code

65201

Country

United States

Facility Name

Centerpoint Medical Center LLC

City

Independence

State/Province

Missouri

ZIP/Postal Code

64057

Country

United States

Facility Name

Truman Medical Centers

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64108

Country

United States

Facility Name

Saint Luke's Hospital of Kansas City

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64111

Country

United States

Facility Name

Radiation Oncology Practice Corporation South

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64114

Country

United States

Facility Name

Saint Joseph Health Center

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64114

Country

United States

Facility Name

North Kansas City Hospital

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64116

Country

United States

Facility Name

Research Medical Center

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64132

Country

United States

Facility Name

Radiation Oncology Practice Corporation - North

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64154

Country

United States

Facility Name

Liberty Radiation Oncology Center

City

Liberty

State/Province

Missouri

ZIP/Postal Code

64068

Country

United States

Facility Name

Heartland Regional Medical Center

City

Saint Joseph

State/Province

Missouri

ZIP/Postal Code

64506

Country

United States

Facility Name

SSM Health Saint Louis University Hospital

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63104

Country

United States

Facility Name

Saint Louis Cancer and Breast Institute-South City

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63109

Country

United States

Facility Name

Mercy Hospital Saint Louis

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63141

Country

United States

Facility Name

Saint Louis-Cape Girardeau CCOP

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63141

Country

United States

Facility Name

Billings Clinic Cancer Center

City

Billings

State/Province

Montana

ZIP/Postal Code

59101

Country

United States

Facility Name

Northern Rockies Radiation Oncology Center

City

Billings

State/Province

Montana

ZIP/Postal Code

59101

Country

United States

Facility Name

Saint Vincent Healthcare

City

Billings

State/Province

Montana

ZIP/Postal Code

59101

Country

United States

Facility Name

Montana Cancer Consortium NCORP

City

Billings

State/Province

Montana

ZIP/Postal Code

59102

Country

United States

Facility Name

Saint Vincent Frontier Cancer Center

City

Billings

State/Province

Montana

ZIP/Postal Code

59102

Country

United States

Facility Name

Deaconess Medical Center

City

Billings

State/Province

Montana

ZIP/Postal Code

59107

Country

United States

Facility Name

Bozeman Deaconess Hospital

City

Bozeman

State/Province

Montana

ZIP/Postal Code

59715

Country

United States

Facility Name

Internal Medicine of Bozeman

City

Bozeman

State/Province

Montana

ZIP/Postal Code

59715

Country

United States

Facility Name

Saint James Community Hospital and Cancer Treatment Center

City

Butte

State/Province

Montana

ZIP/Postal Code

59701

Country

United States

Facility Name

Benefis Healthcare- Sletten Cancer Institute

City

Great Falls

State/Province

Montana

ZIP/Postal Code

59405

Country

United States

Facility Name

Berdeaux, Donald MD (UIA Investigator)

City

Great Falls

State/Province

Montana

ZIP/Postal Code

59405

Country

United States

Facility Name

Great Falls Clinic

City

Great Falls

State/Province

Montana

ZIP/Postal Code

59405

Country

United States

Facility Name

Saint Peter's Community Hospital

City

Helena

State/Province

Montana

ZIP/Postal Code

59601

Country

United States

Facility Name

Glacier Oncology PLLC

City

Kalispell

State/Province

Montana

ZIP/Postal Code

59901

Country

United States

Facility Name

Kalispell Medical Oncology

City

Kalispell

State/Province

Montana

ZIP/Postal Code

59901

Country

United States

Facility Name

Kalispell Regional Medical Center

City

Kalispell

State/Province

Montana

ZIP/Postal Code

59901

Country

United States

Facility Name

Eastern Montana Cancer Center

City

Miles City

State/Province

Montana

ZIP/Postal Code

59301

Country

United States

Facility Name

Montana Cancer Specialists

City

Missoula

State/Province

Montana

ZIP/Postal Code

59802

Country

United States

Facility Name

Saint Patrick Hospital - Community Hospital

City

Missoula

State/Province

Montana

ZIP/Postal Code

59802

Country

United States

Facility Name

Community Medical Hospital

City

Missoula

State/Province

Montana

ZIP/Postal Code

59804

Country

United States

Facility Name

Guardian Oncology and Center for Wellness

City

Missoula

State/Province

Montana

ZIP/Postal Code

59804

Country

United States

Facility Name

Cooper Hospital University Medical Center

City

Camden

State/Province

New Jersey

ZIP/Postal Code

08103

Country

United States

Facility Name

Riverview Medical Center/Booker Cancer Center

City

Red Bank

State/Province

New Jersey

ZIP/Postal Code

07701

Country

United States

Facility Name

University of New Mexico Cancer Center

City

Albuquerque

State/Province

New Mexico

ZIP/Postal Code

87102

Country

United States

Facility Name

Montefiore Medical Center-Wakefield Campus

City

Bronx

State/Province

New York

ZIP/Postal Code

10466

Country

United States

Facility Name

Mary Imogene Bassett Hospital

City

Cooperstown

State/Province

New York

ZIP/Postal Code

13326

Country

United States

Facility Name

Hematology Oncology Associates of Central New York-East Syracuse

City

East Syracuse

State/Province

New York

ZIP/Postal Code

13057

Country

United States

Facility Name

Adirondack Cancer Center

City

Glens Falls

State/Province

New York

ZIP/Postal Code

12801

Country

United States

Facility Name

Glens Falls Hospital

City

Glens Falls

State/Province

New York

ZIP/Postal Code

12801

Country

United States

Facility Name

Interlakes Foundation Inc-Rochester

City

Rochester

State/Province

New York

ZIP/Postal Code

14623

Country

United States

Facility Name

University of Rochester

City

Rochester

State/Province

New York

ZIP/Postal Code

14642

Country

United States

Facility Name

Stony Brook University Medical Center

City

Stony Brook

State/Province

New York

ZIP/Postal Code

11794

Country

United States

Facility Name

State University of New York Upstate Medical University

City

Syracuse

State/Province

New York

ZIP/Postal Code

13210

Country

United States

Facility Name

Syracuse Veterans Administration Medical Center

City

Syracuse

State/Province

New York

ZIP/Postal Code

13210

Country

United States

Facility Name

Carolinas Medical Center/Levine Cancer Institute

City

Charlotte

State/Province

North Carolina

ZIP/Postal Code

28203

Country

United States

Facility Name

Wayne Memorial Hospital

City

Goldsboro

State/Province

North Carolina

ZIP/Postal Code

27534

Country

United States

Facility Name

Wayne Radiation Oncology

City

Goldsboro

State/Province

North Carolina

ZIP/Postal Code

27534

Country

United States

Facility Name

Lenoir Memorial Hospital

City

Kinston

State/Province

North Carolina

ZIP/Postal Code

28501

Country

United States

Facility Name

Vidant Oncology-Kinston

City

Kinston

State/Province

North Carolina

ZIP/Postal Code

28501

Country

United States

Facility Name

Rutherford Hospital

City

Rutherfordton

State/Province

North Carolina

ZIP/Postal Code

28139

Country

United States

Facility Name

Iredell Memorial Hospital

City

Statesville

State/Province

North Carolina

ZIP/Postal Code

28677

Country

United States

Facility Name

Wilson Medical Center

City

Wilson

State/Province

North Carolina

ZIP/Postal Code

27893

Country

United States

Facility Name

Southeast Clinical Oncology Research Consortium NCORP

City

Winston-Salem

State/Province

North Carolina

ZIP/Postal Code

27104

Country

United States

Facility Name

Wake Forest University Health Sciences

City

Winston-Salem

State/Province

North Carolina

ZIP/Postal Code

27157

Country

United States

Facility Name

Mary Rutan Hospital

City

Bellefontaine

State/Province

Ohio

ZIP/Postal Code

43311

Country

United States

Facility Name

Aultman Health Foundation

City

Canton

State/Province

Ohio

ZIP/Postal Code

44710

Country

United States

Facility Name

Adena Regional Medical Center

City

Chillicothe

State/Province

Ohio

ZIP/Postal Code

45601

Country

United States

Facility Name

University of Cincinnati Cancer Center-UC Medical Center

City

Cincinnati

State/Province

Ohio

ZIP/Postal Code

45219

Country

United States

Facility Name

Ohio State University Comprehensive Cancer Center

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43210

Country

United States

Facility Name

Riverside Methodist Hospital

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43214

Country

United States

Facility Name

Columbus NCI Community Oncology Research Program

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43215

Country

United States

Facility Name

Grant Medical Center

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43215

Country

United States

Facility Name

Mount Carmel Health Center West

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43222

Country

United States

Facility Name

Doctors Hospital

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43228

Country

United States

Facility Name

Grandview Hospital

City

Dayton

State/Province

Ohio

ZIP/Postal Code

45405

Country

United States

Facility Name

Good Samaritan Hospital - Dayton

City

Dayton

State/Province

Ohio

ZIP/Postal Code

45406

Country

United States

Facility Name

Miami Valley Hospital

City

Dayton

State/Province

Ohio

ZIP/Postal Code

45409

Country

United States

Facility Name

Miami Valley Hospital North

City

Dayton

State/Province

Ohio

ZIP/Postal Code

45415

Country

United States

Facility Name

Dayton Veterans Affairs Medical Center

City

Dayton

State/Province

Ohio

ZIP/Postal Code

45428

Country

United States

Facility Name

Dayton NCI Community Oncology Research Program

City

Dayton

State/Province

Ohio

ZIP/Postal Code

45459

Country

United States

Facility Name

Grady Memorial Hospital

City

Delaware

State/Province

Ohio

ZIP/Postal Code

43015

Country

United States

Facility Name

Blanchard Valley Hospital

City

Findlay

State/Province

Ohio

ZIP/Postal Code

45840

Country

United States

Facility Name

Atrium Medical Center-Middletown Regional Hospital

City

Franklin

State/Province

Ohio

ZIP/Postal Code

45005-1066

Country

United States

Facility Name

Kettering Medical Center

City

Kettering

State/Province

Ohio

ZIP/Postal Code

45429

Country

United States

Facility Name

Fairfield Medical Center

City

Lancaster

State/Province

Ohio

ZIP/Postal Code

43130

Country

United States

Facility Name

Saint Rita's Medical Center

City

Lima

State/Province

Ohio

ZIP/Postal Code

45801

Country

United States

Facility Name

OhioHealth Mansfield Hospital

City

Mansfield

State/Province

Ohio

ZIP/Postal Code

44903

Country

United States

Facility Name

Marietta Memorial Hospital

City

Marietta

State/Province

Ohio

ZIP/Postal Code

45750

Country

United States

Facility Name

Licking Memorial Hospital

City

Newark

State/Province

Ohio

ZIP/Postal Code

43055

Country

United States

Facility Name

Springfield Regional Medical Center

City

Springfield

State/Province

Ohio

ZIP/Postal Code

45505

Country

United States

Facility Name

Upper Valley Medical Center

City

Troy

State/Province

Ohio

ZIP/Postal Code

45373

Country

United States

Facility Name

Saint Ann's Hospital

City

Westerville

State/Province

Ohio

ZIP/Postal Code

43081

Country

United States

Facility Name

Wright-Patterson Medical Center

City

Wright-Patterson Air Force Base

State/Province

Ohio

ZIP/Postal Code

45433

Country

United States

Facility Name

Greene Memorial Hospital

City

Xenia

State/Province

Ohio

ZIP/Postal Code

45385

Country

United States

Facility Name

Tod Children's Hospital - Forum Health

City

Youngstown

State/Province

Ohio

ZIP/Postal Code

44501

Country

United States

Facility Name

Genesis Healthcare System Cancer Care Center

City

Zanesville

State/Province

Ohio

ZIP/Postal Code

43701

Country

United States

Facility Name

Natalie Warren Bryant Cancer Center at Saint Francis

City

Tulsa

State/Province

Oklahoma

ZIP/Postal Code

74136

Country

United States

Facility Name

Kaiser Permanente Northwest

City

Portland

State/Province

Oregon

ZIP/Postal Code

97227

Country

United States

Facility Name

Oregon Health and Science University

City

Portland

State/Province

Oregon

ZIP/Postal Code

97239

Country

United States

Facility Name

Saint Luke's University Hospital-Bethlehem Campus

City

Bethlehem

State/Province

Pennsylvania

ZIP/Postal Code

18015

Country

United States

Facility Name

Geisinger Medical Center

City

Danville

State/Province

Pennsylvania

ZIP/Postal Code

17822

Country

United States

Facility Name

Penn State Milton S Hershey Medical Center

City

Hershey

State/Province

Pennsylvania

ZIP/Postal Code

17033-0850

Country

United States

Facility Name

Lewistown Hospital

City

Lewistown

State/Province

Pennsylvania

ZIP/Postal Code

17044

Country

United States

Facility Name

Jefferson Torresdale Hospital

City

Philadelphia

State/Province

Pennsylvania

ZIP/Postal Code

19114

Country

United States

Facility Name

West Penn Hospital

City

Pittsburgh

State/Province

Pennsylvania

ZIP/Postal Code

15224

Country

United States

Facility Name

Geisinger Medical Group

City

State College

State/Province

Pennsylvania

ZIP/Postal Code

16801

Country

United States

Facility Name

Mount Nittany Medical Center

City

State College

State/Province

Pennsylvania

ZIP/Postal Code

16803

Country

United States

Facility Name

Geisinger Wyoming Valley/Henry Cancer Center

City

Wilkes-Barre

State/Province

Pennsylvania

ZIP/Postal Code

18711

Country

United States

Facility Name

AnMed Health Hospital

City

Anderson

State/Province

South Carolina

ZIP/Postal Code

29621

Country

United States

Facility Name

Medical University of South Carolina

City

Charleston

State/Province

South Carolina

ZIP/Postal Code

29425

Country

United States

Facility Name

McLeod Regional Medical Center

City

Florence

State/Province

South Carolina

ZIP/Postal Code

29506

Country

United States

Facility Name

Spartanburg Medical Center

City

Spartanburg

State/Province

South Carolina

ZIP/Postal Code

29303

Country

United States

Facility Name

Sanford Cancer Center Oncology Clinic

City

Sioux Falls

State/Province

South Dakota

ZIP/Postal Code

57104

Country

United States

Facility Name

Avera Cancer Institute

City

Sioux Falls

State/Province

South Dakota

ZIP/Postal Code

57105

Country

United States

Facility Name

Medical X-Ray Center

City

Sioux Falls

State/Province

South Dakota

ZIP/Postal Code

57105

Country

United States

Facility Name

Avera McKennan Hospital and University Health Center

City

Sioux Falls

State/Province

South Dakota

ZIP/Postal Code

57117-5045

Country

United States

Facility Name

Sanford USD Medical Center - Sioux Falls

City

Sioux Falls

State/Province

South Dakota

ZIP/Postal Code

57117-5134

Country

United States

Facility Name

Brooke Army Medical Center

City

Fort Sam Houston

State/Province

Texas

ZIP/Postal Code

78234

Country

United States

Facility Name

Wilford Hall Medical Center

City

Lackland Air Force Base

State/Province

Texas

ZIP/Postal Code

78236

Country

United States

Facility Name

Audie L Murphy VA Hospital

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78229

Country

United States

Facility Name

Cancer Therapy and Research Center at The UT Health Science Center at San Antonio

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78229

Country

United States

Facility Name

University Hospital

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78229

Country

United States

Facility Name

University of Texas Health Science Center at San Antonio

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78229

Country

United States

Facility Name

Huntsman Cancer Institute/University of Utah

City

Salt Lake City

State/Province

Utah

ZIP/Postal Code

84112

Country

United States

Facility Name

PeaceHealth Saint Joseph Medical Center

City

Bellingham

State/Province

Washington

ZIP/Postal Code

98225

Country

United States

Facility Name

Harrison HealthPartners Hematology and Oncology-Bremerton

City

Bremerton

State/Province

Washington

ZIP/Postal Code

98310

Country

United States

Facility Name

Kadlec Clinic Hematology and Oncology

City

Kennewick

State/Province

Washington

ZIP/Postal Code

99336

Country

United States

Facility Name

Skagit Valley Hospital

City

Mount Vernon

State/Province

Washington

ZIP/Postal Code

98274

Country

United States

Facility Name

Harborview Medical Center

City

Seattle

State/Province

Washington

ZIP/Postal Code

98104

Country

United States

Facility Name

Minor and James Medical PLLC

City

Seattle

State/Province

Washington

ZIP/Postal Code

98104

Country

United States

Facility Name

Fred Hutchinson Cancer Research Center

City

Seattle

State/Province

Washington

ZIP/Postal Code

98109

Country

United States

Facility Name

Kaiser Permanente Washington

City

Seattle

State/Province

Washington

ZIP/Postal Code

98112

Country

United States

Facility Name

Swedish Medical Center-First Hill

City

Seattle

State/Province

Washington

ZIP/Postal Code

98122

Country

United States

Facility Name

University of Washington Medical Center - Montlake

City

Seattle

State/Province

Washington

ZIP/Postal Code

98195

Country

United States

Facility Name

PeaceHealth United General Medical Center

City

Sedro-Woolley

State/Province

Washington

ZIP/Postal Code

98284

Country

United States

Facility Name

Cancer Care Northwest - Spokane South

City

Spokane

State/Province

Washington

ZIP/Postal Code

99202

Country

United States

Facility Name

PeaceHealth Southwest Medical Center

City

Vancouver

State/Province

Washington

ZIP/Postal Code

98664

Country

United States

Facility Name

Central Washington Hospital

City

Wenatchee

State/Province

Washington

ZIP/Postal Code

98801

Country

United States

Facility Name

Wenatchee Valley Hospital and Clinics

City

Wenatchee

State/Province

Washington

ZIP/Postal Code

98801

Country

United States

Facility Name

West Virginia University Healthcare

City

Morgantown

State/Province

West Virginia

ZIP/Postal Code

26506

Country

United States

Facility Name

HSHS Sacred Heart Hospital

City

Eau Claire

State/Province

Wisconsin

ZIP/Postal Code

54701

Country

United States

Facility Name

Marshfield Clinic Cancer Center at Sacred Heart

City

Eau Claire

State/Province

Wisconsin

ZIP/Postal Code

54701

Country

United States

Facility Name

Gundersen Lutheran Medical Center

City

La Crosse

State/Province

Wisconsin

ZIP/Postal Code

54601

Country

United States

Facility Name

Marshfield Medical Center-Marshfield

City

Marshfield

State/Province

Wisconsin

ZIP/Postal Code

54449

Country

United States

Facility Name

Marshfield Medical Center

City

Marshfield

State/Province

Wisconsin

ZIP/Postal Code

54449

Country

United States

Facility Name

Medical College of Wisconsin

City

Milwaukee

State/Province

Wisconsin

ZIP/Postal Code

53226

Country

United States

Facility Name

Marshfield Clinic-Minocqua Center

City

Minocqua

State/Province

Wisconsin

ZIP/Postal Code

54548

Country

United States

Facility Name

Ascension Saint Mary's Hospital

City

Rhinelander

State/Province

Wisconsin

ZIP/Postal Code

54501

Country

United States

Facility Name

Marshfield Medical Center-Rice Lake

City

Rice Lake

State/Province

Wisconsin

ZIP/Postal Code

54868

Country

United States

Facility Name

Ascension Saint Michael's Hospital

City

Stevens Point

State/Province

Wisconsin

ZIP/Postal Code

54481

Country

United States

Facility Name

Marshfield Clinic-Wausau Center

City

Wausau

State/Province

Wisconsin

ZIP/Postal Code

54401

Country

United States

Facility Name

Marshfield Medical Center - Weston

City

Weston

State/Province

Wisconsin

ZIP/Postal Code

54476

Country

United States

Facility Name

Marshfield Clinic - Wisconsin Rapids Center

City

Wisconsin Rapids

State/Province

Wisconsin

ZIP/Postal Code

54494

Country

United States

Facility Name

Welch Cancer Center

City

Sheridan

State/Province

Wyoming

ZIP/Postal Code

82801

Country

United States

Facility Name

Cross Cancer Institute

City

Edmonton

State/Province

Alberta

ZIP/Postal Code

T6G 1Z2

Country

Canada

Facility Name

CancerCare Manitoba

City

Winnipeg

State/Province

Manitoba

ZIP/Postal Code

R3E 0V9

Country

Canada

Facility Name

The Moncton Hospital

City

Moncton

State/Province

New Brunswick

ZIP/Postal Code

E1C 6Z8

Country

Canada

Facility Name

Doctor H. Bliss Murphy Cancer Centre

City

St. John's

State/Province

Newfoundland and Labrador

ZIP/Postal Code

A1B 3V6

Country

Canada

Facility Name

QEII Health Sciences Centre/Nova Scotia Health Authority

City

Halifax

State/Province

Nova Scotia

ZIP/Postal Code

B3H 2Y9

Country

Canada

Facility Name

Juravinski Cancer Centre at Hamilton Health Sciences

City

Hamilton

State/Province

Ontario

ZIP/Postal Code

L8V 5C2

Country

Canada

Facility Name

London Regional Cancer Program

City

London

State/Province

Ontario

ZIP/Postal Code

N6A 4L6

Country

Canada

Facility Name

University Health Network-Princess Margaret Hospital

City

Toronto

State/Province

Ontario

ZIP/Postal Code

M5G 2M9

Country

Canada

Facility Name

Verdun Hospital Centre

City

Montreal

State/Province

Quebec

ZIP/Postal Code

H4G 2A3

Country

Canada

Facility Name

Allan Blair Cancer Centre

City

Regina

State/Province

Saskatchewan

ZIP/Postal Code

S4T 7T1

Country

Canada

Facility Name

Saskatoon Cancer Centre

City

Saskatoon

State/Province

Saskatchewan

ZIP/Postal Code

S7N 4H4

Country

Canada

12. IPD Sharing Statement

Citations:

PubMed Identifier

22915637

Citation

Radich JP, Kopecky KJ, Appelbaum FR, Kamel-Reid S, Stock W, Malnassy G, Paietta E, Wadleigh M, Larson RA, Emanuel P, Tallman M, Lipton J, Turner AR, Deininger M, Druker BJ. A randomized trial of dasatinib 100 mg versus imatinib 400 mg in newly diagnosed chronic-phase chronic myeloid leukemia. Blood. 2012 Nov 8;120(19):3898-905. doi: 10.1182/blood-2012-02-410688. Epub 2012 Aug 22.

Results Reference

derived

Learn more about this trial

Imatinib Mesylate or Dasatinib in Treating Patients With Previously Untreated Chronic Phase Chronic Myelogenous Leukemia

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