Comparing Fresh Random Platelets and Autologous Cryopreserved Thrombosol Treated Autologous Platelets
Leukemia, Lymphoma
About this trial
This is an interventional treatment trial for Leukemia focused on measuring Leukemia, Lymphoma, ALL, CLL, AML, CML, MDS, Remission, Hematologic Disorder, Transfusion, Thrombosol, Autologous Platelet Transfusion, Platelet Transfusion, Single donor platelet apheresis, Cryopreservation, Thrombocytopenia
Eligibility Criteria
Inclusion Criteria: 1) 1.- Patients in remission with ALL, CLL, AML, CML, MDS will be allowed to participate in this program if their platelet count is >150K, and the hemoglobin level is at least 8.0g/dl. The patient will receive their autologous platelets cryopreserved in ThromboSol or the fresh random platelets (FRP) whenever the need for such transfusions is determined to be clinically indicated by their physician(s). Exclusion Criteria: 1) Patients with detectable circulating malignant cells or ongoing marrow involvement by the tumor will not be eligible.
Sites / Locations
- UT M.D. Anderson Cancer Center
Arms of the Study
Arm 1
Experimental
Platelet Transfusion
ThromboSol-preserved autologous platelet transfusion or Standard platelet transfusion. All patients receive both platelets frozen with Thrombosol and fresh random platelets. The order in which patients receive these two types of platelets randomized in a crossover design. Patients randomly assigned to receive either the sequence FRP then Thrombosol or Thrombosol then FRP. The randomization will occur after second cycle of chemotherapy, since all patients will receive FRP with the first cycle.