Rituximab in Treating Patients With Low Tumor Burden Indolent Non-Hodgkin's Lymphoma
Lymphoma
About this trial
This is an interventional treatment trial for Lymphoma focused on measuring stage III grade 1 follicular lymphoma, stage III grade 2 follicular lymphoma, stage IV grade 1 follicular lymphoma, stage IV grade 2 follicular lymphoma, stage III small lymphocytic lymphoma, stage III marginal zone lymphoma, stage IV small lymphocytic lymphoma, stage IV marginal zone lymphoma, extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue, nodal marginal zone B-cell lymphoma, splenic marginal zone lymphoma
Eligibility Criteria
INCLUSION CRITERIA: Histologically confirmed non-Hodgkin's lymphoma, including 1 of the following: Follicular grade 1 or 2 Small lymphocytic Marginal zone (nodal) Marginal zone (splenic) Mucosa-associated lymphoid tissue (MALT) Stage III or IV disease Must meet the following criteria for low tumor burden: No nodal or extranodal mass at least 7 cm Less than 3 nodal masses greater than 3 cm in diameter No systemic symptoms or B symptoms No splenomegaly greater than 16 cm by a computed tomography (CT) scan No evidence of risk of compression of a vital organ (i.e., ureteral or epidural) No leukemic phase with greater than 5,000/mm^3 circulating lymphocytes No cytopenias, defined as any of the following: Platelet count less than 100,000/mm^3 Hemoglobin less than 10 g/dL Absolute neutrophil count less than 1,500/mm^3 At least 1 objective measurable disease parameter Abnormal positron emission tomography (PET) scans will not constitute evaluable disease unless verified by CT scan or other appropriate imaging Age: 18 and over Eastern Cooperative Oncology Group (ECOG) performance status 0-1 Must meet the following criteria for labs: Hematopoietic Absolute neutrophil count at least 1,500/mm^3* Hemoglobin at least 10 g/dL* Platelet count at least 100,000/mm^3* NOTE: *Without growth factor and/or transfusion support Hepatic Bilirubin no greater than 2 times upper limit of normal (ULN) OR direct bilirubin normal for patients with Gilbert's Syndrome The aspartate transaminase (AST) and alanine transaminase (ALT) ratio (AST/ALT) no greater than 5 times ULN Hepatitis B surface antigen negative Renal Creatinine no greater than 2 times ULN EXCLUSION CRITERIA: Evidence of transformation to a large cell histology Pregnant or nursing. Fertile patients must use effective contraception HIV positive Uncontrolled active infection Other malignancy within the past 2 years except adequately treated basal cell or squamous cell skin cancer or carcinoma in situ of the cervix Prior immunotherapy for lymphoma Prior chemotherapy for lymphoma Concurrent chemotherapy Prior radiotherapy for lymphoma Concurrent radiotherapy Concurrent radioimmunotherapy
Sites / Locations
- Mayo Clinic Scottsdale
- Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
- Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
- Providence Saint Joseph Medical Center - Burbank
- North Bay Cancer Center
- Kaiser Permanente - Fremont
- Kaiser Permanente Medical Center - Hayward
- Memorial Medical Center
- Kaiser Permanente Medical Center - Oakland
- Desert Regional Medical Center Comprehensive Cancer Center
- Veterans Affairs Medical Center - Palo Alto
- Kaiser Permanente Medical Center - Redwood City
- Kaiser Permanente Medical Center - Richmond
- Kaiser Permanente Medical Center - Roseville
- South Sacramento Kaiser-Permanente Medical Center
- Kaiser Permanente Medical Center - Sacramento
- Kaiser Permanente Medical Office -Vandever Medical Office
- Kaiser Permanente Medical Center - San Francisco Geary Campus
- Kaiser Permanente Medical Center - Santa Teresa
- Kaiser Foundation Hospital - San Rafael
- Kaiser Permanente Medical Center - Santa Clara Kiely Campus
- Kaiser Permanente Medical Center - Santa Rosa
- Kaiser Permanente Medical Center - South San Francisco
- Stanford Cancer Center
- Kaiser Permanente Medical Facility - Stockton
- Camino Medical Group - Treatment Center
- Kaiser Permanente Medical Center - Vallejo
- Kaiser Permanente Medical Center - Walnut Creek
- Aurora Presbyterian Hospital
- Boulder Community Hospital
- Penrose Cancer Center at Penrose Hospital
- St. Anthony Central Hospital
- Porter Adventist Hospital
- Presbyterian - St. Luke's Medical Center
- St. Joseph Hospital
- Rose Medical Center
- CCOP - Colorado Cancer Research Program
- Swedish Medical Center
- Poudre Valley Hospital
- Front Range Cancer Specialists
- St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
- North Colorado Medical Center
- Sky Ridge Medical Center
- Hope Cancer Care Center at Longmont United Hospital
- McKee Medical Center
- St. Mary - Corwin Regional Medical Center
- North Suburban Medical Center
- Exempla Lutheran Medical Center
- Eastern Connecticut Hematology and Oncology Associates
- Tunnell Cancer Center at Beebe Medical Center
- CCOP - Christiana Care Health Services
- Walter Reed Army Medical Center
- Eugene M. and Christine E. Lynn Cancer Institute at Boca Raton Community Hospital - Main Campus
- Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
- University of Florida Shands Cancer Center
- Memorial Cancer Institute at Memorial Regional Hospital
- Baptist Cancer Institute - Jacksonville
- Mayo Clinic - Jacksonville
- Ella Milbank Foshay Cancer Center at Jupiter Medical Center
- CCOP - Mount Sinai Medical Center
- Augusta Oncology Associates - Walton Way
- Northeast Georgia Medical Center
- Medical Center of Central Georgia
- Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
- Mountain States Tumor Institute at St. Luke's Regional Medical Center
- Saint Anthony's Hospital at Saint Anthony's Health Center
- Rush-Copley Cancer Care Center
- St. Joseph Medical Center
- Graham Hospital
- Memorial Hospital
- Robert H. Lurie Comprehensive Cancer Center at Northwestern University
- John H. Stroger, Jr. Hospital of Cook County
- Resurrection Medical Center
- Louis A. Weiss Memorial Hospital
- Creticos Cancer Center at Advocate Illinois Masonic Medical Center
- Decatur Memorial Hospital Cancer Care Institute
- Elmhurst Memorial Hospital
- Eureka Community Hospital
- Evanston Northwestern Healthcare - Evanston Hospital
- St. Francis Hospital
- Galesburg Clinic, PC
- Galesburg Cottage Hospital
- Delnor Community Hospital - Geneva
- Ingalls Cancer Care Center at Ingalls Memorial Hospital
- Mason District Hospital
- Hinsdale Hematology Oncology Associates
- Hopedale Medical Complex
- Joliet Oncology-Hematology Associates, Limited - West
- Provena St. Mary's Regional Cancer Center - Kankakee
- La Grange Memorial Hospital
- McDonough District Hospital
- Good Samaritan Regional Health Center
- Hematology Oncology Consultants - Naperville
- BroMenn Regional Medical Center
- Community Cancer Center
- Saint James Hospital and Health Centers Comprehensive Cancer Institute - Olympia Fields
- Community Hospital of Ottawa
- Oncology Hematology Associates of Central Illinois, PC - Ottawa
- Cancer Treatment Center at Pekin Hospital
- Proctor Hospital
- CCOP - Illinois Oncology Research Association
- Oncology Hematology Associates of Central Illinois, PC - Peoria
- Methodist Medical Center of Illinois
- OSF St. Francis Medical Center
- Illinois Valley Community Hospital
- Perry Memorial Hospital
- Swedish-American Regional Cancer Center
- St. Margaret's Hospital
- Regional Cancer Center at Memorial Medical Center
- Carle Cancer Center at Carle Foundation Hospital
- CCOP - Carle Cancer Center
- St. Francis Hospital and Health Centers - Beech Grove Campus
- Elkhart General Hospital
- Fort Wayne Medical Oncology and Hematology
- Center for Cancer Care at Goshen General Hospital
- Indiana University Melvin and Bren Simon Cancer Center
- Veterans Affairs Medical Center - Indianapolis
- William N. Wishard Memorial Hospital
- Howard Community Hospital
- Center for Cancer Therapy at LaPorte Hospital and Health Services
- Clarian Arnett Cancer Care
- Saint Anthony Memorial Health Centers
- Reid Hospital & Health Care Services
- CCOP - Northern Indiana CR Consortium
- Memorial Hospital of South Bend
- Saint Joseph Regional Medical Center
- McFarland Clinic, PC
- Hematology Oncology Associates of the Quad Cities
- Cedar Rapids Oncology Associates
- Genesis Regional Cancer Center at Genesis Medical Center
- Genesis Medical Center - West Campus
- Mercy Capitol Hospital
- CCOP - Iowa Oncology Research Association
- John Stoddard Cancer Center at Iowa Methodist Medical Center
- Medical Oncology and Hematology Associates at John Stoddard Cancer Center
- Medical Oncology and Hematology Associates at Mercy Cancer Center
- Mercy Cancer Center at Mercy Medical Center - Des Moines
- John Stoddard Cancer Center at Iowa Lutheran Hospital
- Mercy Cancer Center at Mercy Medical Center - North Iowa
- McCreery Cancer Center at Ottumwa Regional
- Siouxland Hematology-Oncology Associates, LLP
- Mercy Medical Center - Sioux City
- St. Luke's Regional Medical Center
- Cedar Valley Medical Specialists, PC - West Ridgeway Avenue
- Covenant Cancer Treatment Center
- Cancer Center of Kansas, PA - Chanute
- Cancer Center of Kansas, PA - Dodge City
- Cancer Center of Kansas, PA - El Dorado
- Cancer Center of Kansas-Independence
- Providence Medical Center
- Cancer Center of Kansas, PA - Kingman
- Lawrence Memorial Hospital
- Southwest Medical Center
- Cancer Center of Kansas, PA - Newton
- Menorah Medical Center
- Johnson County Radiation Therapy
- Cancer Center of Kansas, PA - Parsons
- Cancer Center of Kansas, PA - Pratt
- Cancer Center of Kansas, PA - Salina
- Shawnee Mission Medical Center
- Cotton-O'Neil Cancer Center
- St. Francis Comprehensive Cancer Center
- Cancer Center of Kansas, PA - Wellington
- Associates in Womens Health, PA - North Review
- Cancer Center of Kansas, PA - Medical Arts Tower
- Cancer Center of Kansas, PA - Wichita
- CCOP - Wichita
- Via Christi Cancer Center at Via Christi Regional Medical Center
- Cancer Center of Kansas, PA - Winfield
- Pennington Cancer Center at Baton Rouge General
- Mary Bird Perkins Cancer Center - Baton Rouge
- Ochsner Health Center - Bluebonnet
- Terrebonne General Medical Center
- MBCCOP - LSU Health Sciences Center
- Medical Center of Louisiana - New Orleans
- CCOP - Ochsner
- Ochsner Cancer Institute at Ochsner Clinic Foundation
- CancerCare of Maine at Eastern Maine Medical Center
- MaineGeneral Medical Center - Waterville
- St. Agnes Hospital Cancer Center
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- Upper Chesapeake Medical Center
- Union Hospital Cancer Program at Union Hospital
- Frederick Memorial Hospital Regional Cancer Therapy Center
- Kaiser Permanente Mid-Atlantic Medical Group-Largo Medical Facility
- Kaiser Permanente - Towson
- Kaiser Permanente Capital Area Medical Group - Shady Grove Facility
- Tufts-NEMC Cancer Center
- Berkshire Hematology Oncology, PC
- Morton Hospital & Medical Center
- Hickman Cancer Center at Bixby Medical Center
- Saint Joseph Mercy Cancer Center
- CCOP - Michigan Cancer Research Consortium
- Oakwood Cancer Center at Oakwood Hospital and Medical Center
- Green Bay Oncology, Limited - Escanaba
- Genesys Hurley Cancer Institute
- Hurley Medical Center
- Van Elslander Cancer Center at St. John Hospital and Medical Center
- Dickinson County Healthcare System
- Foote Memorial Hospital
- Borgess Medical Center
- West Michigan Cancer Center
- Bronson Methodist Hospital
- Haematology-Oncology Associates of Ohio and Michigan, PC
- Sparrow Regional Cancer Center
- Community Cancer Center of Monroe
- Mercy Memorial Hospital - Monroe
- Northern Michigan Hospital
- William Beaumont Hospital - Royal Oak Campus
- Seton Cancer Institute at Saint Mary's - Saginaw
- Lakeland Regional Cancer Care Center - St. Joseph
- Oncology Care Associates, PLLC
- St. John Macomb Hospital
- MeritCare Bemidji
- Fairview Ridges Hospital
- Mercy and Unity Cancer Center at Mercy Hospital
- Duluth Clinic Cancer Center - Duluth
- CCOP - Duluth
- Miller - Dwan Medical Center
- St. Luke's Hospital Cancer Care Center
- Fairview Southdale Hospital
- Mercy and Unity Cancer Center at Unity Hospital
- Hutchinson Area Health Care
- Meeker County Memorial Hospital
- HealthEast Cancer Care at St. John's Hospital
- Minnesota Oncology Hematology, PA - Maplewood
- Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
- Hennepin County Medical Center - Minneapolis
- Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center
- Mayo Clinic Cancer Center
- CentraCare Clinic - River Campus
- Coborn Cancer Center
- CCOP - Metro-Minnesota
- Park Nicollet Cancer Center
- Regions Hospital Cancer Care Center
- HealthEast Cancer Care at St. Joseph's Hospital
- United Hospital
- St. Francis Cancer Center at St. Francis Medical Center
- Ridgeview Medical Center
- Willmar Cancer Center at Rice Memorial Hospital
- HealthEast Cancer Care at Woodwinds Health Campus
- Minnesota Oncology Hematology, PA - Woodbury
- Hattiesburg Clinic, PA at Forrest General
- Hematology & Oncology Clinic
- Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital
- Saint Francis Medical Center
- Independence Regional Health Center
- Truman Medical Center - Hospital Hill
- Saint Luke's Cancer Institute at Saint Luke's Hospital
- Kansas City Cancer Center at St. Joseph's Medical Mall
- St. Joseph Medical Center
- North Kansas City Hospital
- Parvin Radiation Oncology
- CCOP - Kansas City
- Radiation Oncology Associates of Kansas City at Northland Radiation Oncology Center
- Heartland Regional Medical Center
- Midwest Hematology Oncology Group, Incorporated
- Missouri Baptist Cancer Center
- Arch Medical Services, Incorporated at Center for Cancer Care and Research
- CCOP - St. Louis-Cape Girardeau
- David C. Pratt Cancer Center at St. John's Mercy
- CCOP - Cancer Research for the Ozarks
- St. John's Regional Health Center
- Hulston Cancer Center at Cox Medical Center South
- CCOP - Montana Cancer Consortium
- Hematology-Oncology Centers of the Northern Rockies - Billings
- Northern Rockies Radiation Oncology Center
- St. Vincent Healthcare Cancer Care Services
- Billings Clinic - Downtown
- Bozeman Deaconess Cancer Center
- St. James Healthcare Cancer Care
- Big Sky Oncology
- Great Falls Clinic - Main Facility
- Sletten Cancer Institute at Benefis Healthcare
- St. Peter's Hospital
- Glacier Oncology, PLLC
- Kalispell Medical Oncology at KRMC
- Kalispell Regional Medical Center
- Community Medical Center
- Guardian Oncology and Center for Wellness
- Montana Cancer Specialists at Montana Cancer Center
- Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
- Good Samaritan Cancer Center at Good Samaritan Hospital
- Cancer Resource Center - Lincoln
- CCOP - Missouri Valley Cancer Consortium
- Methodist Estabrook Cancer Center
- Immanuel Medical Center
- Alegant Health Cancer Center at Bergan Mercy Medical Center
- Creighton University Medical Center
- Carson Tahoe Cancer Center at Carson Tahoe Regional Medical Center
- University Medical Center of Southern Nevada
- CCOP - Nevada Cancer Research Foundation
- Veterans Affairs Medical Center - East Orange
- Dizzy Gillespie Cancer Institute at Englewood Hospital and Medical Center
- St. Joseph's Hospital and Medical Center
- AtlantiCare Cancer Care Institute at AtlantiCare Regional Medical Center - Mainland Campus
- Valley Hospital - Ridgewood
- Somerset Medical Center
- Frederick R. and Betty M. Smith Cancer Treatment Center
- Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare
- Cancer Institute of New Jersey at Cooper - Voorhees
- Underwood Memorial Hospital
- Albert Einstein Cancer Center at Albert Einstein College of Medicine
- Jacobi Medical Center
- Our Lady of Mercy Medical Center Comprehensive Cancer Center
- Finger Lakes Hematology and Oncology
- SUNY Upstate Medical University Hospital
- Mission Hospitals - Memorial Campus
- Blumenthal Cancer Center at Carolinas Medical Center
- Presbyterian Cancer Center at Presbyterian Hospital
- Batte Cancer Center at Northeast Medical Center
- Wayne Memorial Hospital, Incorporated
- Leo W. Jenkins Cancer Center at ECU Medical School
- Pardee Memorial Hospital
- Kinston Medical Specialists
- Rutherford Hospital
- Bismarck Cancer Center
- Medcenter One Hospital Cancer Care Center
- Mid Dakota Clinic, PC
- St. Alexius Medical Center Cancer Center
- CCOP - MeritCare Hospital
- MeritCare Broadway
- Altru Cancer Center at Altru Hospital
- Trinity CancerCare Center
- McDowell Cancer Center at Akron General Medical Center
- Mary Rutan Hospital
- Wood County Oncology Center
- Mercy Cancer Center at Mercy Medical Center
- Aultman Cancer Center at Aultman Hospital
- Adena Regional Medical Center
- Christ Hospital Cancer Center
- Case Comprehensive Cancer Center
- MetroHealth Cancer Care Center at MetroHealth Medical Center
- Cleveland Clinic Cancer Center at Fairview Hospital
- Cleveland Clinic Taussig Cancer Center
- Riverside Methodist Hospital Cancer Care
- CCOP - Columbus
- Grant Medical Center Cancer Care
- Mount Carmel Health - West Hospital
- Doctors Hospital at Ohio Health
- Grandview Hospital
- Good Samaritan Hospital
- David L. Rike Cancer Center at Miami Valley Hospital
- Samaritan North Cancer Care Center
- Veterans Affairs Medical Center - Dayton
- CCOP - Dayton
- Grady Memorial Hospital
- Blanchard Valley Medical Associates
- Middletown Regional Hospital
- Community Oncology Group at Cleveland Clinic Cancer Center
- Charles F. Kettering Memorial Hospital
- Fairfield Medical Center
- St. Rita's Medical Center
- Lima Memorial Hospital
- Strecker Cancer Center at Marietta Memorial Hospital
- Northwest Ohio Oncology Center
- St. Luke's Hospital
- Licking Memorial Cancer Care Program at Licking Memorial Hospital
- St. Charles Mercy Hospital
- Toledo Clinic - Oregon
- Firelands Regional Medical Center
- North Coast Cancer Care, Incorporated
- Mercy Medical Center
- Community Hospital of Springfield and Clark County
- Flower Hospital Cancer Center
- Mercy Hospital of Tiffin
- Toledo Hospital
- St. Vincent Mercy Medical Center
- Medical University of Ohio Cancer Center
- CCOP - Toledo Community Hospital
- Toledo Clinic, Incorporated - Main Clinic
- UVMC Cancer Care Center at Upper Valley Medical Center
- Fulton County Health Center
- Mount Carmel St. Ann's Cancer Center
- Clinton Memorial Hospital
- Cleveland Clinic - Wooster
- United States Air Force Medical Center - Wright-Patterson
- Ruth G. McMillan Cancer Center at Greene Memorial Hospital
- Genesis - Good Samaritan Hospital
- Natalie Warren Bryant Cancer Center at St. Francis Hospital
- Rosenfeld Cancer Center at Abington Memorial Hospital
- Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
- St. Luke's Cancer Network at St. Luke's Hospital
- Bryn Mawr Hospital
- Geisinger Cancer Institute at Geisinger Health
- Mercy Fitzgerald Hospital
- Delaware County Regional Cancer Center at Delaware County Memorial Hospital
- Oncology Hematology Associates of Northern Pennsylvania, PC at Hahne Regional Cancer Center
- Dale and Frances Hughes Cancer Center at Pocono Medical Center
- Easton Regional Cancer Center at Easton Hospital
- Ephrata Cancer Center at Ephrata Community Hospital
- Penn State Cancer Institute at Milton S. Hershey Medical Center
- Richard G. Laube Cancer Center at ACMH
- Lancaster General Hospital
- Central Pennsylvania Hematology and Medical Oncology Associates, PC
- Lewistown Hospital
- Riddle Memorial Hospital Cancer Center
- Cancer Center of Paoli Memorial Hospital
- Abramson Cancer Center of the University of Pennsylvania
- Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
- Joan Karnell Cancer Center at Pennsylvania Hospital
- Fox Chase Cancer Center - Philadelphia
- Frankford Hospital Cancer Center - Torresdale Campus
- Albert Einstein Cancer Center
- UPMC Cancer Centers
- Pottstown Memorial Regional Cancer Center
- McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center
- Guthrie Cancer Center at Guthrie Clinic Sayre
- Mercy Hospital Cancer Center - Scranton
- Hematology and Oncology Associates of Northeastern Pennsylvania
- Grand View Hospital
- Geisinger Medical Group - Scenery Park
- Mount Nittany Medical Center
- Associates in Hematology-Oncology, PC at Crozer Regional Cancer Center
- Chester County Hospital
- Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
- Susquehanna Cancer Center at Divine Providence Hospital
- CCOP - Main Line Health
- Lankenau Cancer Center at Lankenau Hospital
- York Cancer Center at Apple Hill Medical Center
- AnMed Cancer Center
- McLeod Regional Medical Center
- CCOP - Greenville
- CCOP - Upstate Carolina
- Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
- Oncology Services of Aberdeen
- Rapid City Regional Hospital
- Avera Cancer Institute
- Medical X-Ray Center, PC
- Sanford Cancer Center at Sanford USD Medical Center
- Green Mountain Oncology Group
- Martha Jefferson Hospital Cancer Care Center
- University of Virginia Cancer Center
- Danville Regional Medical Center
- Kaiser Permanente Medical Center - Fair Oaks
- Fredericksburg Oncology, Incorporated
- Veterans Affairs Medical Center - Richmond
- Virginia Commonwealth University Massey Cancer Center
- St. Francis Hospital
- Good Samaritan Cancer Center
- Rockwood Clinic Cancer Treatment Center
- Franciscan Cancer Center at St. Joseph Medical Center
- Allenmore Hospital
- CCOP - Northwest
- MultiCare Regional Cancer Center at Tacoma General Hospital
- St. Clare Hospital
- Edwards Comprehensive Cancer Center at Cabell Huntington Hospital
- Langlade Memorial Hospital
- Fox Valley Hematology and Oncology - East Grant Street
- Center for Cancer Treatment & Prevention at Sacred Heart Hospital
- Marshfield Clinic Cancer Care at Regional Cancer Center
- Vince Lombardi Cancer Center at Aurora Lakeland Medical Center - Elkhorn
- Central Wisconsin Cancer Program at Agnesian HealthCare
- Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
- Green Bay Oncology, Limited at St. Mary's Hospital
- St. Mary's Hospital Medical Center - Green Bay
- St. Vincent Hospital Regional Cancer Center
- Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
- Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
- Dean Medical Center - Madison
- University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
- Holy Family Memorial Medical Center Cancer Care Center
- Bay Area Cancer Care Center at Bay Area Medical Center
- Marshfield Clinic - Marshfield Center
- Saint Joseph's Hospital
- Aurora Sinai Medical Center
- Medical Consultants, Limited
- Froedtert Hospital and Medical College of Wisconsin
- Medical College of Wisconsin Cancer Center
- Marshfield Clinic - Lakeland Center
- Green Bay Oncology, Limited - Oconto Falls
- Ministry Medical Group at Saint Mary's Hospital
- Marshfield Clinic - Indianhead Center
- Saint Michael's Hospital Cancer Center
- Green Bay Oncology, Limited - Sturgeon Bay
- Marshfield Clinic - Wausau Center
- University of Wisconcin Cancer Center at Aspirus Wausau Hospital
- Marshfield Clinic - Weston Center
- Marshfield Clinic - Wisconsin Rapids Center
- Welch Cancer Center at Sheridan Memorial Hospital
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Arm A: Rituximab Retreatment
Arm B: Rituximab Scheduled
Patients receive rituximab IV once a week for 4 weeks upon disease progression provided time to progression is more than 6 months.
Patients receive a single dose of rituximab IV once every 13 weeks until disease progression and in the absence of unacceptable toxicity.