Isoproterenol Challenge to Detect Arrhythmogenic Right Ventricular Cardiomyopathy
Arrhythmic Right Ventricular Cardiomyopathy
About this trial
This is an observational trial for Arrhythmic Right Ventricular Cardiomyopathy focused on measuring ARVC/ARVD, Genetics, Sudden Death, Heart, MRI, Cardiomyopathy, Arrhythmogenic Right Ventricular, ARVC, Healthy Volunteer, HV
Eligibility Criteria
INCLUSION CRITERIA: Patients with ARVC: Either gender, aged greater than 5 years. The presence of two major criteria; one major and two minor criteria; or four minor criteria from separate diagnostic categories. Normal Volunteers: Age and gender matched with ARVC patients, age greater than 18 years. No known cardiac disease. Normal EKG, normal echocardiogram, normal Bruce protocol treadmill exercise test. Family Members of Patients with ARVC: Either gender, aged greater than 5 years. A proband with ARVC EXCLUSION CRITERIA: Patients with ARVC: Pregnancy or lactation excludes tests with potential risk, e.g. radiation, isoprenaline, MRI, but does not exclude 12-lead ECG and echocardiogram. Coronary artery disease. Known infiltrate or congenital heart disease that could mimic the appearances of ARVC. Asthma prevents participation in Isoproterenol infusion. Any other condition that would prevent participation in the study. Normal Volunteers: Pregnancy or lactation. Asthma. Coronary artery disease, hypertension, diabetes, hypertrophic cardiomyopathy, or other known cardiomyopathy. Known infiltrative or congenital heart disease that could mimic the appearances of ARVC. Any Acute or chronic illness. Chronic drug therapy. Family Members of Patients with ARVC: Pregnancy or lactation excludes tests with potential risk, e.g. radiation, isoprenaline, MRI, but does not exclude 12-lead ECG and echocardiogram. Coronary artery disease. Known infiltrative or congenital heart disease that could mimic the appearances of ARVC. Asthma prevents participation in Isoproterenol infusion. Any other condition that would prevent participation in the study.
Sites / Locations
- National Institutes of Health Clinical Center (CC)