Fluorouracil, Cisplatin, and Radiation Therapy in Treating Patients With Stage II, Stage III, or Stage IV Nasopharyngeal Cancer
Head and Neck Cancer
About this trial
This is an interventional treatment trial for Head and Neck Cancer focused on measuring stage II lymphoepithelioma of the nasopharynx, stage III lymphoepithelioma of the nasopharynx, stage IV lymphoepithelioma of the nasopharynx, stage II squamous cell carcinoma of the nasopharynx, stage III squamous cell carcinoma of the nasopharynx, stage IV squamous cell carcinoma of the nasopharynx
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed nasopharyngeal cancer (NPC) Type I-III disease by WHO classification Stage IIB-IVB disease by TNM classification with no distant metastases by chest x-ray, liver ultrasonography or CT scan, and bone scintigraphy Lymph node metastases evaluated by CT scan, MRI, and palpation Progression range of primary lesion evaluated by MRI and pharyngeal fiberoptic endoscopy PATIENT CHARACTERISTICS: Age 18 to 70 Performance status ECOG 0-2 Life expectancy Not specified Hematopoietic WBC > 3,500/mm^3 Platelet count > 100,000/mm^3 Hepatic No severe hepatic dysfunction Renal Creatinine clearance > 60 mL/min No severe renal dysfunction Cardiovascular No severe cardiac dysfunction Pulmonary No severe pulmonary dysfunction Other No other active cancer PRIOR CONCURRENT THERAPY: Biologic therapy No prior biologic therapy for NPC Chemotherapy No prior systemic chemotherapy for NPC Endocrine therapy Not specified Radiotherapy Not specified Surgery Not specified
Sites / Locations
- National Hospital Organization - Medical Center of Kure
- Kanazawa University
- Kyoto Prefectural University of Medicine
- Aichi Cancer Center
- Nara Medical University Cancer Center
- Graduate School of Medical Science at the University of Ryukyu
- Mie University School of Medicine