Tanespimycin in Treating Young Patients With Recurrent or Refractory Leukemia or Solid Tumors

Inclusion Criteria: Histologically confirmed diagnosis of 1 of the following malignancies: Leukemia Lymphoid, myeloid, or mixed lineage Relapsed (in second or greater relapse) or refractory disease, confirmed by 1 of the following: Bone marrow relapse, defined as either M3 bone marrow (> 25% blasts in the bone marrow aspirate) OR M2 bone marrow (5-25% blasts in the bone marrow aspirate) at any time after complete remission is attained CNS relapse, defined as at least 5 WBC/mL by cytospin of any cerebrospinal fluid (CSF) specimen OR less than 5 WBC/mL by cytospin of 2 consecutive CSF specimens obtained >= 4 weeks apart and having definitive confirmation that blasts are derived from the original leukemic clone by molecular cytogenetics, multiparameter flow cytometry, or immunostaining of >= 2 antigens Patients with underlying chronic myeloid leukemia must have > 25% blasts in the bone marrow aspirate Patients with M3 bone marrow AND extramedullary sites of disease, other than leptomeningeal disease, are eligible Solid tumor One of the following tumor types: Neuroblastoma Ewing's sarcoma Osteosarcoma Desmoplastic small round cell tumor Rhabdomyosarcoma Progressed after prior standard therapy OR no effective standard therapy exists Measurable or nonmeasurable disease No known brain metastases No active leptomeningeal leukemia, defined by the following criteria: WBC > 5/mm^3 in cerebrospinal fluid (CSF) Unequivocal confirmation of leukemic blasts in CSF by cell morphology No symptomatic CNS disease (e.g., cranial nerve abnormalities) without cytologic abnormality in CSF Performance status - Karnofsky 70-100% (for patients > 10 years of age) Performance status - Lansky 70-100% (for patients =< 10 years of age) More than 8 weeks Absolute neutrophil count >= 750/mm^3 Platelet count >= 75,000/mm^3 (transfusion independent) Hemoglobin >= 8.5 g/dL (transfusion allowed) Bilirubin < 1.5 mg/dL ALT and AST =< 2.5 times upper limit of normal (ULN) INR =< 1.5 times ULN Albumin > 2.0 g/dL Creatinine =< 1.5 times ULN for age Creatinine clearance or radioisotope glomerular filtration rate > 60 mL/min Ejection fraction >= 50% Shortening fraction >= 28% QTc < 450 msec for men (470 msec for women) No congenital long QT syndrome LVEF > 40% by MUGA No symptomatic congestive heart failure No cardiac arrhythmia No New York Heart Association class III or IV heart failure No myocardial infarction within the past year No uncontrolled dysrhythmias No poorly controlled angina More than 12 months since active ischemic heart disease No history of serious ventricular arrhythmia (ventricular tachycardia or ventricular fibrillation >= 3 beats in a row) No left bundle branch block No other significant cardiac disease No pulmonary fibrosis by radiography No ongoing or active bacterial or fungal infection No other uncontrolled illness No psychiatric illness or social situation that would preclude study compliance No history of serious allergic reaction attributed to eggs or dimethyl sulfoxide Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception Recovered from all immunotherapy At least 6 months since prior allogeneic stem cell transplantation At least 3 months since prior autologous stem cell transplantation At least 2 weeks since prior biologic agents (e.g., monoclonal antibodies) At least 1 week since prior filgrastim (G-CSF) or sargramostim (GM-CSF) Recovered from all prior chemotherapy At least 2 weeks since prior chemotherapy (for patients with leukemia only) At least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin) (for patients with solid tumors) No prior oxaliplatin No concurrent corticosteroids except for the treatment of adrenal crises in patients with suppressed hypothalamic-pituitary-adrenal axis response OR for treatment of allergic reactions to medications or blood products Recovered from all prior radiotherapy At least 6 months since prior radiotherapy to >= 50% of the pelvis At least 6 months since prior radiotherapy to substantial bone marrow, including total body irradiation At least 4 weeks since prior local (small port) radiotherapy No prior radiotherapy to the heart At least 1 week since prior retinoids No concurrent antiretroviral therapy for HIV-positive patients No concurrent medication to control arrhythmias No concurrent medications that prolong or may prolong QTc interval No other concurrent investigational agents No other concurrent anticancer therapy