Irbesartan in Heart Failure With Preserved Systolic Function (I-Preserve)
Congestive Heart Failure
About this trial
This is an interventional treatment trial for Congestive Heart Failure
Eligibility Criteria
Inclusion Criteria: Male or female age >= 60 years with current symptoms of heart failure consistent with New York Heart Association (NYHA) class II-IV Left ventricular ejection fraction (LVEF) > = 45% Willing to provide written informed consent AND hospitalization for heart failure within the past 6 months OR various abnormalities in electrocardiogram, echocardiogram or chest x-ray indicating heart disease. Exclusion Criteria: Acute myocardial infarction within 3 months; Heart revascularization procedure within 3 months; Hospitalization for angina within 3 months; Other heart surgery Life-threatening or uncontrolled arrhythmia Subjects with an implantable cardioverter-defibrillator that has discharged in the past 3 months; Stroke or surgery of the arteries in the brain within 3 months; Serious lung disease which requires use of home oxygen. Significantly low blood pressure Significantly high blood pressure Other known diseases that may limit life expectancy to <3 years; Known or suspected bilateral kidney artery narrowing; Geographic or social factors making study participation and follow-up impractical.
Sites / Locations
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Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
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