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VITATOPS: A Study of VITAmins TO Prevent Stroke

Primary Purpose

Stroke, Transient Ischemic Attack

Status
Completed
Phase
Not Applicable
Locations
International
Study Type
Interventional
Intervention
Active VITATOPS Tablet (folic acid 2mg, B6 25mg , B12 500ug) or placebo
Placebo
Sponsored by
VITATOPS
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional prevention trial for Stroke focused on measuring VITATOPS, stroke, prevention, multivitamins, homocysteine

Eligibility Criteria

undefined - undefined (Child, Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria: Patients presenting within seven months of stroke (ischemic or hemorrhagic) or TIA Agree to take study medication Be geographically accessible for follow-up Provide written informed consent Exclusion Criteria: Taking folic acid or B6 on medical advice Use of vitamin supplements containing folate, B6 or B12 (unless patient agrees to take study medication instead of the vitamin supplements which they usually take) Taking Methotrexate for any reason Pregnancy or women of child-bearing potential who are at risk of pregnancy Limited life expectancy

Sites / Locations

  • JFK Hospital / Seton Hall University
  • Abington Memorial Hospital
  • South Carolina VA Hospital
  • University of South Carolina
  • Central Coast Neuroscience Research
  • Bankstown Hospital
  • John Hunter Hospital
  • Liverpool Hospital
  • Royal Perth Hospital
  • Greenslopes Hospital
  • Nambour Hospital
  • Flinders & Griffiths
  • Royal Hobart Hospital
  • Alfred Hospital
  • Beleura & Frankston Hospital
  • Box Hill Hospital
  • National Stroke Research Institute - Austin Health
  • Fremantle Hospital
  • Joondalup Hospital
  • Sir Charles Gairdner Hospital
  • Karl-Franzens University Graz
  • Algemeen Ziekenhuis Sint-Jan Autonome Verzorgingsinstelling
  • Universidade Federal Fluminense & Universidade Federal do Rio de Janeiro
  • Sarajishvili Institute of Neurology and Neurosurgery
  • Queen Mary Hospital
  • Prince of Wales Hospital
  • Rajah Muthaiah Medical College
  • St John's Medical College Hospital
  • SP Medical College
  • Baby Memorial Hospital
  • KS Hospital
  • Amrita Institute of Medical Science
  • Care Hopstial
  • Mahaveer Hospital & Research Centre
  • Mediciti Hospital
  • MGM Medical College & MY Hospital
  • Monilek Hospital
  • Centauri, The Albert Road Clinic
  • CSMMU
  • Christian Medical College & Hospital
  • G.B. Pant Hospital
  • Sir Ganga Ram Hospital
  • Sadhbavana Medical & Heart Institute
  • Railway Hospital
  • Poona Hospital
  • Ruby Hall Clinic
  • Neurocenter
  • Care Hospital
  • Mahatma Gandhi Institute
  • Spedali Civili Di Brescia
  • Ospedale di Circolo de Busto Arsizio
  • Ospedale di Macerata
  • IRCCS Fondazione Istituto Neurologico C Mondino
  • Perugia Stroke Service & Citta Della Peive
  • University of Perugia
  • Ospedale R Guzzardi
  • Hospital Universiti Sains Malaysia
  • University of Malaya Medical Centre
  • City Emergency Hospital
  • Slotervaartziekenhuis
  • Oosterscheldeziekenhuis
  • University Medical Center Utrecht
  • Auckland Hospital
  • Hawkes Bay Hospital
  • Palmerston North Hospital
  • North Shore Hospital
  • Wellington Hospital
  • KRL University
  • Pakistan Institute of Medical Sciences
  • DUHS - Civil Hospital
  • DUHS - Jinnah Hospital
  • POF Hospital Wah Cantt.
  • Cagayan de Oro Medical Center
  • Cebu Doctor's Hospital
  • Cebu Velez General Hospital/ Visayas Comm. Medical Center
  • Chong Hua Hospital
  • Vicente Sotto Memorial Hospital
  • Cagayan Valley Medical Center
  • Jose R Reyes Memorial Medical Centre
  • University Santo Tomas Hospital
  • Hospital Visconde de Salreu
  • Hospital de Santa Maria
  • Hospital Distrital de Oliverira de Azemeis
  • Hospital Geral de Santo Antonio
  • University of Novi Sad - Neurology & Neurosurgery
  • Singapore General Hospital
  • National Hospital of Sri Lanka
  • University of Kelaniya
  • University Hospital of North Staffordshire
  • Aberdeen Royal Infirmary
  • Redbridge Health Care
  • Barnsley District Hospital
  • The Royal Victoria Hospital
  • Bronglais General Hospital
  • Western General Hospital, Edinburgh
  • Royal Devon & Exeter Hospital
  • Western Infirmary
  • St Luke's Hospital
  • William Harvey Hospital
  • University Hospital Aintree
  • Altnagelvin Hospital
  • Luton and Dunstable Hospital
  • Royal Victoria Infirmary, Newcastle
  • North Tyneside District General Hospital
  • Nottingham City Hospital
  • St Mary's Paddington Hospital
  • Rotherham General Hospital
  • Stirling Royal Infirmary
  • Stepping Hill Hospital
  • Musgrove Park Hosptial
  • Torbay Hospital

Arms of the Study

Arm 1

Arm 2

Arm Type

Active Comparator

Placebo Comparator

Arm Label

Active VITATOPS Tablet (folic acid 2mg, B6 25mg , B12 500ug)

Placebo Tablet

Arm Description

Active Treatment Arm: VITATOPS study tablet (folate 2 mg, B6 25 mg, B12 500 ug). Taken daily for the duration of the study.

Placebo Treatment Arm: The placebo tablet will have the same appearance, taste and texture as the vitamin preparation and contains excipients, coating and coating aids.

Outcomes

Primary Outcome Measures

Non-fatal Stroke, Non-fatal Myocardial Infarction or Death Due to Vascular Causes

Secondary Outcome Measures

Full Information

First Posted
November 24, 2004
Last Updated
September 7, 2020
Sponsor
VITATOPS
Collaborators
National Health and Medical Research Council, Australia, National Heart Foundation, Australia, Medical Health Research Infrastructure Council, Australia
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1. Study Identification

Unique Protocol Identification Number
NCT00097669
Brief Title
VITATOPS: A Study of VITAmins TO Prevent Stroke
Official Title
VITATOPS - A Study of VITAmins TO Prevent Stroke
Study Type
Interventional

2. Study Status

Record Verification Date
January 2014
Overall Recruitment Status
Completed
Study Start Date
November 1998 (undefined)
Primary Completion Date
June 2009 (Actual)
Study Completion Date
June 2009 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
VITATOPS
Collaborators
National Health and Medical Research Council, Australia, National Heart Foundation, Australia, Medical Health Research Infrastructure Council, Australia

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The VITATOPS study is a multi-center, randomized, double blind, placebo-controlled secondary stroke prevention trial to determine whether the addition of vitamin supplements (B12 500 ug, B6 25 mg, Folate 2 mg) to best medical/surgical management (including modification of risk factors) will reduce the combined incidence of recurrent vascular events (stroke, myocardial infarction) and vascular death in patients with recent stroke or transient ischemic attack (TIA). All patients presenting to one of the participating neurologists or general physicians within seven months of stroke (ischemic or hemorrhagic) or TIA (eye or brain) are eligible for this trial. Eligible patients will be randomized in a double-blind fashion to receive multi-vitamins or placebo, 1 tablet daily. The primary outcome event is the composite event "stroke, myocardial infarction, or death from any vascular cause", whichever occurs first. Our target is to recruit a total of 8,000 patients over the next two years with a median follow-up of 2.5 years. Recruitment to the trial began in November 1998 and is planned to continue until December 2005. We aim to complete final follow-up by the end of 2006. However, the Steering Committee will be flexible in dictating the need for ongoing recruitment and continuing follow-up, depending on the overall rate of the primary outcome event in the entire cohort at each interim analysis.
Detailed Description
Background: Epidemiological studies suggest that raised plasma concentrations of total homocysteine (tHcy) may be a common, causal and treatable risk factor for atherothromboembolic ischemic stroke, dementia and depression. Although tHcy can be lowered effectively with small doses of folic acid, vitamin B12 and vitamin B6, it is not known whether lowering tHcy, by means of multivitamin therapy, can prevent stroke and other major atherothromboembolic vascular events, dementia and depression. Purpose: To determine whether vitamin supplements (folic acid 2 mg, B6 25 mg, B12 500 ug) reduce the risk of stroke, other serious vascular events, dementia and depression in patients with recent stroke or transient ischemic attacks of the brain or eye (TIA). Methods: An international, multi-center, randomized, double-blind, placebo-controlled clinical trial. Subjects: Patients with stroke or TIA in the previous 7 months. Primary outcome measure: Non-fatal stroke, non-fatal myocardial infarction, or death due to vascular causes. Secondary outcome measures: TIA, Revascularisation procedures, Dementia, Depression. Sample size calculation: To reliably identify a 15% reduction in relative risk of the primary outcome event from 8% to 6.8% per year with an alpha of 0.05 and power of 80%, 8,000 patients need to be randomized and followed-up for an average of two years. Current progress: As of November, 2004, more than 4,400 patients have been randomized in 73 centers in 19 countries in five continents: Australia, Austria, Belgium, Brazil, Hong Kong, Italy, Malaysia, Moldova, Netherlands, New Zealand, Pakistan, Philippines, Portugal, Republic of Georgia, Serbia & Monte Negro, Singapore, Sri Lanka, United Kingdom, and United States. VITATOPS aims to recruit and follow up 8,000 patients between 2000 and 2006, and provide a reliable estimate of the safety and effectiveness of dietary supplementation with folic acid, vitamin B12, and vitamin B6 in reducing recurrent serious vascular events, dementia and depression among a wide range of patients with stroke and TIA.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Stroke, Transient Ischemic Attack
Keywords
VITATOPS, stroke, prevention, multivitamins, homocysteine

7. Study Design

Primary Purpose
Prevention
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
8164 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Active VITATOPS Tablet (folic acid 2mg, B6 25mg , B12 500ug)
Arm Type
Active Comparator
Arm Description
Active Treatment Arm: VITATOPS study tablet (folate 2 mg, B6 25 mg, B12 500 ug). Taken daily for the duration of the study.
Arm Title
Placebo Tablet
Arm Type
Placebo Comparator
Arm Description
Placebo Treatment Arm: The placebo tablet will have the same appearance, taste and texture as the vitamin preparation and contains excipients, coating and coating aids.
Intervention Type
Drug
Intervention Name(s)
Active VITATOPS Tablet (folic acid 2mg, B6 25mg , B12 500ug) or placebo
Other Intervention Name(s)
VITATOPS study tablet
Intervention Description
multivitamin
Intervention Type
Other
Intervention Name(s)
Placebo
Primary Outcome Measure Information:
Title
Non-fatal Stroke, Non-fatal Myocardial Infarction or Death Due to Vascular Causes
Time Frame
The primary outcome was measured over a median follow-up period of 3.4 years (interquartile range IQR 1.0-5.5 years).

10. Eligibility

Sex
All
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Patients presenting within seven months of stroke (ischemic or hemorrhagic) or TIA Agree to take study medication Be geographically accessible for follow-up Provide written informed consent Exclusion Criteria: Taking folic acid or B6 on medical advice Use of vitamin supplements containing folate, B6 or B12 (unless patient agrees to take study medication instead of the vitamin supplements which they usually take) Taking Methotrexate for any reason Pregnancy or women of child-bearing potential who are at risk of pregnancy Limited life expectancy
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Graeme Hankey, MBBS/MD
Organizational Affiliation
Royal Perth Hospital / University of Western Australia
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Ross Baker, MBBS/BMedSc
Organizational Affiliation
Royal Perth Hospital
Official's Role
Study Director
First Name & Middle Initial & Last Name & Degree
John Eikelboom, MBBS/FRACP
Organizational Affiliation
Royal Perth Hospital
Official's Role
Study Director
First Name & Middle Initial & Last Name & Degree
Konrad Jamrozik, MBBS
Organizational Affiliation
The University of Queensland
Official's Role
Study Director
First Name & Middle Initial & Last Name & Degree
Frank van Bockxmeer, BSc/PhD
Organizational Affiliation
Royal Perth Hospital
Official's Role
Study Director
First Name & Middle Initial & Last Name & Degree
Siobhan Hickling, BSc/MPH
Organizational Affiliation
The University of Western Australia
Official's Role
Study Director
First Name & Middle Initial & Last Name & Degree
Anna Gelavis, BPharm
Organizational Affiliation
Royal Perth Hospital
Official's Role
Study Director
Facility Information:
Facility Name
JFK Hospital / Seton Hall University
City
New York
State/Province
New York
Country
United States
Facility Name
Abington Memorial Hospital
City
Abington
State/Province
Pennsylvania
Country
United States
Facility Name
South Carolina VA Hospital
City
Columbia
State/Province
South Carolina
Country
United States
Facility Name
University of South Carolina
City
Columbia
State/Province
South Carolina
Country
United States
Facility Name
Central Coast Neuroscience Research
City
Gosford
Country
Australia
Facility Name
Bankstown Hospital
City
New South Wales
Country
Australia
Facility Name
John Hunter Hospital
City
New South Wales
Country
Australia
Facility Name
Liverpool Hospital
City
New South Wales
Country
Australia
Facility Name
Royal Perth Hospital
City
Perth
Country
Australia
Facility Name
Greenslopes Hospital
City
Queensland
Country
Australia
Facility Name
Nambour Hospital
City
Queensland
Country
Australia
Facility Name
Flinders & Griffiths
City
South Australia
Country
Australia
Facility Name
Royal Hobart Hospital
City
Tasmania
Country
Australia
Facility Name
Alfred Hospital
City
Victoria
Country
Australia
Facility Name
Beleura & Frankston Hospital
City
Victoria
Country
Australia
Facility Name
Box Hill Hospital
City
Victoria
Country
Australia
Facility Name
National Stroke Research Institute - Austin Health
City
Victoria
Country
Australia
Facility Name
Fremantle Hospital
City
Western Australia
Country
Australia
Facility Name
Joondalup Hospital
City
Western Australia
Country
Australia
Facility Name
Sir Charles Gairdner Hospital
City
Western Australia
Country
Australia
Facility Name
Karl-Franzens University Graz
City
Graz
Country
Austria
Facility Name
Algemeen Ziekenhuis Sint-Jan Autonome Verzorgingsinstelling
City
Brugge
Country
Belgium
Facility Name
Universidade Federal Fluminense & Universidade Federal do Rio de Janeiro
City
Rio de Janeiro
Country
Brazil
Facility Name
Sarajishvili Institute of Neurology and Neurosurgery
City
Tbilisi
Country
Georgia
Facility Name
Queen Mary Hospital
City
Pokfulam
Country
Hong Kong
Facility Name
Prince of Wales Hospital
City
Shatin
Country
Hong Kong
Facility Name
Rajah Muthaiah Medical College
City
Annamalainagar
Country
India
Facility Name
St John's Medical College Hospital
City
Bangalore
Country
India
Facility Name
SP Medical College
City
Bikaner
Country
India
Facility Name
Baby Memorial Hospital
City
Calicut
Country
India
Facility Name
KS Hospital
City
Chennai
Country
India
Facility Name
Amrita Institute of Medical Science
City
Cochin
Country
India
Facility Name
Care Hopstial
City
Hyderabad
Country
India
Facility Name
Mahaveer Hospital & Research Centre
City
Hyderabad
Country
India
Facility Name
Mediciti Hospital
City
Hyderabad
Country
India
Facility Name
MGM Medical College & MY Hospital
City
Indore
Country
India
Facility Name
Monilek Hospital
City
Jaipur
Country
India
Facility Name
Centauri, The Albert Road Clinic
City
Kolkata
Country
India
Facility Name
CSMMU
City
Lucknow
Country
India
Facility Name
Christian Medical College & Hospital
City
Ludhiana
Country
India
Facility Name
G.B. Pant Hospital
City
New Delhi
Country
India
Facility Name
Sir Ganga Ram Hospital
City
New Delhi
Country
India
Facility Name
Sadhbavana Medical & Heart Institute
City
Patiaala
Country
India
Facility Name
Railway Hospital
City
Perambur
Country
India
Facility Name
Poona Hospital
City
Pune
Country
India
Facility Name
Ruby Hall Clinic
City
Pune
Country
India
Facility Name
Neurocenter
City
Trichy
Country
India
Facility Name
Care Hospital
City
Visakhapatnam
Country
India
Facility Name
Mahatma Gandhi Institute
City
Wardha
Country
India
Facility Name
Spedali Civili Di Brescia
City
Brescia
Country
Italy
Facility Name
Ospedale di Circolo de Busto Arsizio
City
Busto Arsizio
Country
Italy
Facility Name
Ospedale di Macerata
City
Macerata
Country
Italy
Facility Name
IRCCS Fondazione Istituto Neurologico C Mondino
City
Pavia
Country
Italy
Facility Name
Perugia Stroke Service & Citta Della Peive
City
Perugia
Country
Italy
Facility Name
University of Perugia
City
Perugia
Country
Italy
Facility Name
Ospedale R Guzzardi
City
Vittoria
Country
Italy
Facility Name
Hospital Universiti Sains Malaysia
City
Kelantan
Country
Malaysia
Facility Name
University of Malaya Medical Centre
City
Kuala Lumpur
Country
Malaysia
Facility Name
City Emergency Hospital
City
Chishinau
Country
Moldova, Republic of
Facility Name
Slotervaartziekenhuis
City
Amsterdam
Country
Netherlands
Facility Name
Oosterscheldeziekenhuis
City
Goes
Country
Netherlands
Facility Name
University Medical Center Utrecht
City
Utrecht
Country
Netherlands
Facility Name
Auckland Hospital
City
Auckland
Country
New Zealand
Facility Name
Hawkes Bay Hospital
City
Hastings
Country
New Zealand
Facility Name
Palmerston North Hospital
City
Palmerston North
Country
New Zealand
Facility Name
North Shore Hospital
City
Takapuna
Country
New Zealand
Facility Name
Wellington Hospital
City
Wellington South
Country
New Zealand
Facility Name
KRL University
City
Islamabad
Country
Pakistan
Facility Name
Pakistan Institute of Medical Sciences
City
Islamabad
Country
Pakistan
Facility Name
DUHS - Civil Hospital
City
Karachi
Country
Pakistan
Facility Name
DUHS - Jinnah Hospital
City
Karachi
Country
Pakistan
Facility Name
POF Hospital Wah Cantt.
City
Wah Cantt
Country
Pakistan
Facility Name
Cagayan de Oro Medical Center
City
Cebu City
Country
Philippines
Facility Name
Cebu Doctor's Hospital
City
Cebu City
Country
Philippines
Facility Name
Cebu Velez General Hospital/ Visayas Comm. Medical Center
City
Cebu City
Country
Philippines
Facility Name
Chong Hua Hospital
City
Cebu City
Country
Philippines
Facility Name
Vicente Sotto Memorial Hospital
City
Cebu City
Country
Philippines
Facility Name
Cagayan Valley Medical Center
City
East Santiago City
Country
Philippines
Facility Name
Jose R Reyes Memorial Medical Centre
City
Manila
Country
Philippines
Facility Name
University Santo Tomas Hospital
City
Manila
Country
Philippines
Facility Name
Hospital Visconde de Salreu
City
Estarreja
Country
Portugal
Facility Name
Hospital de Santa Maria
City
Lisboa
Country
Portugal
Facility Name
Hospital Distrital de Oliverira de Azemeis
City
Oliveira de Azemeis
Country
Portugal
Facility Name
Hospital Geral de Santo Antonio
City
Porto
Country
Portugal
Facility Name
University of Novi Sad - Neurology & Neurosurgery
City
Novisad
Country
Serbia
Facility Name
Singapore General Hospital
City
Singapore
Country
Singapore
Facility Name
National Hospital of Sri Lanka
City
Colombo
Country
Sri Lanka
Facility Name
University of Kelaniya
City
Ragama
Country
Sri Lanka
Facility Name
University Hospital of North Staffordshire
City
Stoke on Trent
State/Province
Shaffordshire
Country
United Kingdom
Facility Name
Aberdeen Royal Infirmary
City
Aberdeen
Country
United Kingdom
Facility Name
Redbridge Health Care
City
Barking
Country
United Kingdom
Facility Name
Barnsley District Hospital
City
Barnsley
Country
United Kingdom
Facility Name
The Royal Victoria Hospital
City
Belfast
Country
United Kingdom
Facility Name
Bronglais General Hospital
City
Ceredigion
Country
United Kingdom
Facility Name
Western General Hospital, Edinburgh
City
Edinburgh
Country
United Kingdom
Facility Name
Royal Devon & Exeter Hospital
City
Exeter
Country
United Kingdom
Facility Name
Western Infirmary
City
Glasgow
Country
United Kingdom
Facility Name
St Luke's Hospital
City
Huddersfield
Country
United Kingdom
Facility Name
William Harvey Hospital
City
Kent
Country
United Kingdom
Facility Name
University Hospital Aintree
City
Liverpool
Country
United Kingdom
Facility Name
Altnagelvin Hospital
City
Londonderry
Country
United Kingdom
Facility Name
Luton and Dunstable Hospital
City
Luton
Country
United Kingdom
Facility Name
Royal Victoria Infirmary, Newcastle
City
Newcastle
Country
United Kingdom
Facility Name
North Tyneside District General Hospital
City
North Shields
Country
United Kingdom
Facility Name
Nottingham City Hospital
City
Nottingham
Country
United Kingdom
Facility Name
St Mary's Paddington Hospital
City
Paddington
Country
United Kingdom
Facility Name
Rotherham General Hospital
City
Rotherham
Country
United Kingdom
Facility Name
Stirling Royal Infirmary
City
Stirling
Country
United Kingdom
Facility Name
Stepping Hill Hospital
City
Stockport
Country
United Kingdom
Facility Name
Musgrove Park Hosptial
City
Taunton
Country
United Kingdom
Facility Name
Torbay Hospital
City
Torquay
Country
United Kingdom

12. IPD Sharing Statement

Citations:
PubMed Identifier
24004645
Citation
Gommans J, Yi Q, Eikelboom JW, Hankey GJ, Chen C, Rodgers H; VITATOPS trial study group. The effect of homocysteine-lowering with B-vitamins on osteoporotic fractures in patients with cerebrovascular disease: substudy of VITATOPS, a randomised placebo-controlled trial. BMC Geriatr. 2013 Sep 3;13:88. doi: 10.1186/1471-2318-13-88.
Results Reference
derived
PubMed Identifier
23765945
Citation
Hankey GJ, Ford AH, Yi Q, Eikelboom JW, Lees KR, Chen C, Xavier D, Navarro JC, Ranawaka UK, Uddin W, Ricci S, Gommans J, Schmidt R, Almeida OP, van Bockxmeer FM; VITATOPS Trial Study Group. Effect of B vitamins and lowering homocysteine on cognitive impairment in patients with previous stroke or transient ischemic attack: a prespecified secondary analysis of a randomized, placebo-controlled trial and meta-analysis. Stroke. 2013 Aug;44(8):2232-9. doi: 10.1161/STROKEAHA.113.001886. Epub 2013 Jun 13.
Results Reference
derived
PubMed Identifier
23093615
Citation
Cavalieri M, Schmidt R, Chen C, Mok V, de Freitas GR, Song S, Yi Q, Ropele S, Grazer A, Homayoon N, Enzinger C, Loh K, Wong KS, Wong A, Xiong Y, Chang HM, Wong MC, Fazekas F, Eikelboom JW, Hankey GJ; VITATOPS Trial Study Group. B vitamins and magnetic resonance imaging-detected ischemic brain lesions in patients with recent transient ischemic attack or stroke: the VITAmins TO Prevent Stroke (VITATOPS) MRI-substudy. Stroke. 2012 Dec;43(12):3266-70. doi: 10.1161/STROKEAHA.112.665703. Epub 2012 Oct 23.
Results Reference
derived
PubMed Identifier
22554931
Citation
Hankey GJ, Eikelboom JW, Yi Q, Lees KR, Chen C, Xavier D, Navarro JC, Ranawaka UK, Uddin W, Ricci S, Gommans J, Schmidt R; VITATOPS trial study group. Antiplatelet therapy and the effects of B vitamins in patients with previous stroke or transient ischaemic attack: a post-hoc subanalysis of VITATOPS, a randomised, placebo-controlled trial. Lancet Neurol. 2012 Jun;11(6):512-20. doi: 10.1016/S1474-4422(12)70091-1. Epub 2012 May 2.
Results Reference
derived
PubMed Identifier
22474057
Citation
Hankey GJ, Eikelboom JW, Yi Q, Lees KR, Chen C, Xavier D, Navarro JC, Ranawaka UK, Uddin W, Ricci S, Gommans J, Schmidt R; VITAmins TO Prevent Stroke (VITATOPS) Trial Study Group. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: results of a randomized placebo-controlled trial. Stroke. 2012 Jun;43(6):1572-7. doi: 10.1161/STROKEAHA.111.641613. Epub 2012 Apr 3.
Results Reference
derived
PubMed Identifier
20976769
Citation
Almeida OP, Marsh K, Alfonso H, Flicker L, Davis TM, Hankey GJ. B-vitamins reduce the long-term risk of depression after stroke: The VITATOPS-DEP trial. Ann Neurol. 2010 Oct;68(4):503-10. doi: 10.1002/ana.22189.
Results Reference
derived
PubMed Identifier
20688574
Citation
VITATOPS Trial Study Group. B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebo-controlled trial. Lancet Neurol. 2010 Sep;9(9):855-65. doi: 10.1016/S1474-4422(10)70187-3. Epub 2010 Aug 3.
Results Reference
derived
PubMed Identifier
18705976
Citation
VITATOPS Trial Study Group; Hankey GJ, Algra A, Chen C, Wong MC, Cheung R, Wong L, Divjak I, Ferro J, de Freitas G, Gommans J, Groppa S, Hill M, Spence D, Lees K, Lisheng L, Navarro J, Ranawaka U, Ricci S, Schmidt R, Slivka A, Tan K, Tsiskaridze A, Uddin W, Vanhooren G, Xavier D, Armitage J, Hobbs M, Le M, Sudlow C, Wheatley K, Yi Q, Bulder M, Eikelboom JW, Hankey GJ, Ho WK, Jamrozik K, Klijn K, Koedam E, Langton P, Nijboer E, Tuch P, Pizzi J, Tang M, Antenucci M, Chew Y, Chinnery D, Cockayne C, Loh K, McMullin L, Smith F, Schmidt R, Chen C, Wong MC, de Freitas G, Hankey GJ, Loh K, Song S. VITATOPS, the VITAmins TO prevent stroke trial: rationale and design of a randomised trial of B-vitamin therapy in patients with recent transient ischaemic attack or stroke (NCT00097669) (ISRCTN74743444). Int J Stroke. 2007 May;2(2):144-50. doi: 10.1111/j.1747-4949.2007.00111.x.
Results Reference
derived
Links:
URL
http://www.heartfoundation.com.au/
Description
National Heart Foundation
URL
http://www.strokesociety.com.au/
Description
Stroke Society of Australasia Inc.

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VITATOPS: A Study of VITAmins TO Prevent Stroke

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