PROCLAIM: Effect of AC2592 Administered by Continuous Subcutaneous Infusion in Subjects With Advanced Chronic Congestive Heart Failure
Congestive Heart Failure
About this trial
This is an interventional treatment trial for Congestive Heart Failure focused on measuring Congestive Heart Failure, AC2592, GLP-1, Amylin, metabolic abnormality
Eligibility Criteria
Main Inclusion Criteria: Has heart failure classified as New York Heart Association (NYHA) Class III or Class IV at screening despite treatment with standard therapy. Is able to perform a treadmill test. Has an HbA1c of <= 11%. Is physically and mentally capable of operating the continuous subcutaneous infusion (CSCI) pump (i.e., adequate vision, manual dexterity, and mental capacity), or has a dedicated caretaker or adult family member who meets this requirement. Main Exclusion Criteria: Has received metformin or nesiritide within 2 weeks prior to screening visit. Is currently participating in any other clinical study, or has received an investigational drug within 1 month of the screening period. Has participated previously in a study using GLP-1, exenatide, or exenatide LAR. Is using a left ventricular assist device or other mechanical circulatory support.
Sites / Locations
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Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
1
2