Cellular Adoptive Immunotherapy in Treating Patients With Stage III or Stage IV Ovarian Cancer or Primary Peritoneal Cancer
Ovarian Cancer, Peritoneal Cavity Cancer
About this trial
This is an interventional treatment trial for Ovarian Cancer focused on measuring recurrent ovarian epithelial cancer, stage III ovarian epithelial cancer, stage IV ovarian epithelial cancer, peritoneal cavity cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed stage III or IV ovarian epithelial cancer or primary peritoneal cavity cancer meeting 1 of the following criteria: Progressive* or persistent* disease during or after primary chemotherapy Recurrent disease < 6 months after completion of primary therapy that had resulted in a complete response Persistent* or recurrent disease after second-line or additional therapies NOTE: *Progression or persistence can be based on serological (CA 125 > 100 U/mL OR 2 times baseline), radiographic (measurable or evaluable disease), or second-look surgical findings Tumor expressing NY-ESO-1 determined by IHC or RT-PCR HLA type expressing DPB*0401, DPB1*0201, DRB1*07 No CNS metastases PATIENT CHARACTERISTICS: Age 18 to 75 Performance status Karnofsky 70-100% Life expectancy More than 16 weeks Hematopoietic Not specified Hepatic Not specified Renal Creatinine ≤ 2.0 mg/dL Cardiovascular No congestive heart failure* No clinically significant hypotension* No symptoms of coronary artery disease* No cardiac arrhythmias on EKG requiring drug therapy* No history of cardiovascular disease* No other significant cardiovascular abnormalities* NOTE: *Patients with any of the above undergo a stress test and/or echocardiography before being determined ineligible for study participation Pulmonary FEV_1 ≥ 60% of predicted* DLCO ≥ 55%* NOTE: *Patients with clinically significant pulmonary dysfunction only Other Not pregnant or nursing Fertile patients must use effective contraception HIV negative No active infection No oral temperature > 38.2°C within the past 72 hours No systemic infection requiring chronic maintenance or suppressive therapy PRIOR CONCURRENT THERAPY: Biologic therapy No other concurrent immunotherapy (e.g., interleukins, interferons, vaccines, intravenous immunoglobulin, or expanded polyclonal tumor-infiltrating lymphocytes or lymphokine-activated killer cell therapy) Chemotherapy See Disease Characteristics At least 3 weeks since prior standard or experimental chemotherapy Endocrine therapy No concurrent systemic corticosteroids except for treatment-related toxicity Radiotherapy At least 3 weeks since prior radiotherapy Surgery See Disease Characteristics Other At least 3 weeks since prior immunosuppressive therapy More than 3 weeks since prior investigational drugs and recovered No other concurrent investigational agents No concurrent pentoxifylline
Sites / Locations
- Fred Hutchinson Cancer Research Center