Intravenous CG7870 in Combination With Docetaxel in Patients With Metastatic Hormone-Refractory Prostate Cancer

Inclusion Criteria: Histologically confirmed adenocarcinoma of the prostate Metastatic prostate cancer deemed to be unresponsive or refractory to hormone therapy (after discontinuation of anti-androgen therapy) Detectable metastases by bone scan, and/or CT scan, and/or MRI, and/or CXR ECOG performance status 0-1 Exclusion Criteria: Transitional cell, small cell, neuroendocrine, or squamous cell prostate cancer History of deep vein thrombosis or pulmonary embolus Patients taking anticoagulants (such as coumadin or Heparin). The use of aspirin while on study is acceptable. History of a bleeding disorder or recent clinically significant bleeding Seropositive for HIV History of Hepatitis B, Hepatitis C, or chronic liver disease Prior gene therapy or immunotherapy Prior chemotherapy for prostate cancer Radiation therapy within 4 weeks of the first treatment. History of myocardial infarction within 6 months of the first treatment History of cerebrovascular accident History of previous malignancy, except for the following: adequately treated basal cell or squamous cell skin cancer, superficial bladder cancer, adequately treated Stage I or II cancer currently in complete remission, or any other cancer that has been in complete remission for at least 5 years Evidence of active prostatitis Known hypersensitivity to docetaxel or to other drugs formulated with polysorbate 80