Sildenafil for Chronic Obstructive Pulmonary Disease
Pulmonary Disease, Chronic Obstructive, Emphysema
About this trial
This is an interventional treatment trial for Pulmonary Disease, Chronic Obstructive focused on measuring Chronic Obstructive Pulmonary Disease, Emphysema, Phosphodiesterase inhibitors, Sildenafil, Exercise testing, Quality of life
Eligibility Criteria
Inclusion Criteria: Clinical diagnosis of chronic obstructive pulmonary disease (COPD) or emphysema FEV1/FVC ratio < 70% FEV1 < 80% Stable medication regimen Exclusion Criteria: COPD exacerbation or hospitalization in the past 3 months Heart disease Contraindication to sildenafil Unrelated lung disease Inability to walk or pedal on a stationary bike Pregnancy or breast-feeding Pulmonary hypertension at rest
Sites / Locations
- Columbia Univeristy, College of Physicians and Surgeons
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
Sildenafil / Placebo
Placebo / Sildenafil
Sildenafil first, followed by washout, followed by placebo
Placebo first, followed by washout, followed by Sildenafil