Vaccine Therapy and GM-CSF in Treating Patients With Progressive Non-Hodgkin's Lymphoma
Lymphoma
About this trial
This is an interventional treatment trial for Lymphoma focused on measuring recurrent grade 1 follicular lymphoma, recurrent grade 2 follicular lymphoma, recurrent grade 3 follicular lymphoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed follicular B-cell non-Hodgkin's lymphoma (NHL) Grade 1, 2, or 3 Progressive disease AND did not receive autologous immunoglobulin idiotype-KLH conjugate vaccine (FavId™) while enrolled on protocol FAV-ID-06 Meets 1 of the following criteria: Received salvage therapy after completion of protocol FAV-ID-06 At least 4 weeks, but no more than 4 months, since prior salvage therapy Did not receive salvage therapy after completion of protocol FAV-ID-06 At least 4 weeks, but no more than 4 months, since completion of prior treatment on protocol FAV-ID-06 No history of CNS lymphoma OR meningeal lymphomatosis PATIENT CHARACTERISTICS: Age 18 and over Performance status ECOG 0-2 Life expectancy Not specified Hematopoietic Not specified Hepatic Not specified Renal Not specified Cardiovascular No history of congestive heart failure Pulmonary No history of compromised pulmonary function Other Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception HIV negative No active bacterial, viral, or fungal infection No psychiatric disorder No other serious nonmalignant disease that would preclude study participation PRIOR CONCURRENT THERAPY: Biologic therapy See Disease Characteristics No prior allogeneic transplantation* No prior rituximab regimen* other than that administered on protocol FAV-ID-06 (rituximab 375 mg/m^2 IV weekly for 4 weeks) Chemotherapy No prior purine analogues* (e.g., fludarabine or cladribine) Endocrine therapy No prior or concurrent steroids (e.g., steroid doses in excess of daily replacement) Radiotherapy Not specified Surgery Not specified Other Recovered from prior salvage therapy No prior or concurrent immunosuppressive therapy No prior investigational agents* No other concurrent antilymphoma therapy NOTE: *As salvage therapy administered between completion of protocol FAV-ID-06 and enrollment onto this study
Sites / Locations
- UAB Comprehensive Cancer Center
- Tower Cancer Research Foundation
- Rebecca and John Moores UCSD Cancer Center
- Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center
- Kaiser Permanente Medical Center - Kaiser Foundation Hospital - San Diego
- Sharp Memorial Hospital Cancer Center
- UCSF Helen Diller Family Comprehensive Cancer Center
- Stanford Cancer Center
- Kaiser Permanente Medical Center - Vallejo
- Rocky Mountain Cancer Centers - Denver Midtown
- Helen F. Graham Cancer Center at Christiana Hospital
- Lombardi Comprehensive Cancer Center at Georgetown University Medical Center
- Center for Hematology-Oncology - Boca Raton
- H. Lee Moffitt Cancer Center and Research Institute at University of South Florida
- Kootenai Cancer Center - Coeur d'Alene
- Robert H. Lurie Comprehensive Cancer Center at Northwestern University
- Rush Cancer Institute at Rush University Medical Center
- Indiana University Melvin and Bren Simon Cancer Center
- Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center
- Lucille P. Markey Cancer Center at University of Kentucky
- Ochsner Cancer Institute at Ochsner Clinic Foundation
- Greater Baltimore Medical Center Cancer Center
- Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
- Josephine Ford Cancer Center at Henry Ford Hospital
- Mayo Clinic Cancer Center
- Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
- Montana Cancer Specialists at Montana Cancer Center
- New Mexico Cancer Center
- Our Lady of Mercy Medical Center Comprehensive Cancer Center
- Don Monti Comprehensive Cancer Center at North Shore University Hospital
- Memorial Sloan-Kettering Cancer Center
- James P. Wilmot Cancer Center at University of Rochester Medical Center
- Wake Forest University Comprehensive Cancer Center
- Mid Dakota Clinic, PC
- Roger Maris Cancer Center at MeritCare Hospital
- Charles M. Barrett Cancer Center at University Hospital
- Case Comprehensive Cancer Center
- Cleveland Clinic Taussig Cancer Center
- Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center
- Providence Cancer Center at Providence Portland Medical Center
- Kaiser Permanente Medical Office - Interstate Medical Office Central
- Knight Cancer Institute at Oregon Health and Science University
- Geisinger Cancer Institute at Geisinger Health
- Fox Chase Cancer Center - Philadelphia
- Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital
- Sarah Cannon Cancer Center at Centennial Medical Center
- Cancer Care Centers of South Texas - Medical Center
- University of Virginia Cancer Center
- Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
- University of Wisconsin Paul P. Carbone Comprehensive Cancer Center