Proton Beam Radiation Therapy in Treating Young Patients Who Have Undergone Biopsy or Surgery for Medulloblastoma or Pineoblastoma
Brain and Central Nervous System Tumors, Long-term Effects Secondary to Cancer Therapy in Children
About this trial
This is an interventional treatment trial for Brain and Central Nervous System Tumors focused on measuring long-term effects secondary to cancer therapy in children, untreated childhood medulloblastoma, untreated childhood pineoblastoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed medulloblastoma or pineoblastoma Standard-risk or high-risk disease Must have undergone biopsy or attempted surgical resection of the tumor within the past 35 days Requires craniospinal irradiation PATIENT CHARACTERISTICS: Age 3 to 21 Performance status Not specified Life expectancy Not specified Hematopoietic Not specified Hepatic Not specified Renal Not specified Other Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy Not specified Chemotherapy No more than 1 prior chemotherapy regimen No prior IV or intrathecal methotrexate No prior intrathecal thiotepa Concurrent cisplatin-based chemotherapy, including chemotherapy administered on another study, allowed Endocrine therapy Not specified Radiotherapy No prior radiotherapy Surgery See Disease Characteristics
Sites / Locations
- Massachusetts General Hospital
Arms of the Study
Arm 1
Experimental
Radiation therapy
This is a single arm study of radiation therapy with protons to standard doses.