Back to resultsA Study of the Safety and Efficacy of Nitric Oxide Reduction in Patients With Cardiogenic Shock After a Heart Attack
Primary Purpose
Shock, Cardiogenic
Status
Terminated
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Tilarginine Acetate Injection intravenous infusion
Sponsored by
About this trial
This is an interventional treatment trial for Shock, Cardiogenic focused on measuring shock, cardiogenic, "myocardial infarction"
Eligibility Criteria
Inclusion Criteria: Confirmed myocardial infarction (heart attack) Confirmed persistent cardiogenic shock Confirmed patency of the infarct related artery (heart attack artery has been opened through the use of a blood clot dissolving drug or a balloon or angioplasty heart procedure) Less than 24 hour duration of cardiogenic shock (the time since the heart attack occurred and the artery was opened must be less than 24 hours) Exclusion Criteria: Infection Other cause of shock (not heart attack) Shock due to heart valve disease Severe heart valve disease Right sided heart failure Shock due to arrhythmia (irregular heart rhythm) Severe kidney disease Aortic dissection (tear in aorta) Adult respiratory distress syndrome (ARDS) (severe lung inflammation) Severe brain damage Severe irreversible multi-system failure (failure of multiple body organs) Major chest or abdominal surgical procedure within 30 days except if prior CABG and reocclusion occurs Primary pulmonary hypertension (high blood pressure in the arteries of the lungs) Age younger than 18 years Requirement for emergency coronary artery bypass grafting (CABG) or infarct-related artery occlusion (heart attack artery completely blocked) Ongoing or recent participation in another clinical trial of an investigational drug Prior enrollment in this study or rapid resolution of cardiogenic shock before treatment (shock gets better before study starts) Positive pregnancy test in women who are of childbearing potential
Sites / Locations
- The Heart Group, PC
- Sparks Regional Medical Center
- Banner Baywood Heart Hospital
- Mayo Clinic Hospital
- Central Arkansas Cardiovascular Research Group (CACRG)
- Los Angeles Cardiology Associates
- University of Southern California, LAC + USC Medical Center
- Cedars-Sinai Medical Center
- Stanford University School of Medicine
- Desert Cardiology
- Mercy General Hospital
- South Denver Cardiology Associates, PC
- Christiana Care Health Services
- Washington Hospital Center
- Florida Cardiovascular Research Center
- Watson Clinic, LLP
- Health First Clinical Research Institute
- University of Miami School of Medicine
- Mt. Sinai Medical Center
- Mediquest Research Group
- Orlando Regional Medical Center
- Cardiovascular Center of Sarasota
- Emory Crawford Long Hospital
- John H. Stroger Jr. Hospital of Cook County
- Heart Care Midwest
- Trinity Medical Center
- Parkview Research Center
- Iowa Health, Des Moines
- Iowa Heart Centre
- University of Iowa Hospital
- University of Kansas Hospital
- University of Kentucky
- Ochsner Clinic Foundation
- Northeast Cardiology Associates
- Maine Medical Center
- Brigham and Women's Hospital
- Boston Medical Center
- Beth Israel Deaconess Medical Center
- Interventional Cardiovascular Research - Lahey Clinic
- University of Massachusetts Medical School
- Fallon Cardiology - St. Vincent Hospital
- University of Michigan Health Systems
- Henry Ford Hospital
- Spectrum Health Hospitals
- Nisus Research at Northern Michigan Hospital
- William Beaumont Hospital
- St. Mary's Duluth Clinic Health System
- Mayo Clinic Minnesota
- Saint Louis University
- Washington University
- BryanLGH Heart Institute
- University of Nebraska Medical Center
- Cooper Health System
- Newark Beth Israel Medical Center
- Lenox Hill Heart and Vascular Institute of New York
- Mount Sinai Medical Center
- Rochester Cardio-Pulmonary Group, P.C.
- University of Rochester Medical Center
- Cardiology Associates of Schenectady
- Mission Hospitals
- UNC Chapel Hill
- Sanger Clinic
- Duke University Medical Center
- LeBauer Cardiovascular Research
- Forsyth Medical Center
- Cleveland Clinic Foundation
- MidWest Cardiology Research Foundation
- The Oregon Clinic
- Providence Heart & Vascular Institute
- The Heart Care Group
- Penn State Hershey Medical Center
- Lancaster General Hospital
- Allegheny General Hospital
- Guthrie Clinic
- The Miriam Hospital
- South Carolina Heart Center
- Johnson City Medical Center
- St. Thomas Cardiology Consultants
- Ben Taub General Hospital, Baylor College of Medicine
- The Methodist Hospital
- University of Texas Medical School
- LDS Hospital
- Fletcher Allen Healthcare
- Calgary Heart Centre Alberta
- Royal Alexandria Hospital
- University of Alberta
- Vancouver Hospital and Health Sciences Centre
- St. Paul's Hospital
- Victoria Heart Institute Foundation
- St. Boniface General Hospital
- NB Heart Centre
- Cardiology Research - QEII Health Science Centre
- QEII Health Science Centre - Cardiology Research
- Hamilton Health Sciences, General Site
- London Health Sciences Centre
- Trilium Health Centre
- Southlake Regional Health Centre
- University of Ottawa
- St. Michael's Hospital Toronto
- University Health Network - Toronto General Hospital
- Montreal Heart Institute
- Quebec Heart Institute
Outcomes
Primary Outcome Measures
All cause mortality at 30 days post randomization
Secondary Outcome Measures
Number of patients demonstrating resolution of cardiogenic shock compared to placebo
The duration of cardiogenic shock compared to placebo
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT00112281
Brief Title
A Study of the Safety and Efficacy of Nitric Oxide Reduction in Patients With Cardiogenic Shock After a Heart Attack
Official Title
A Phase III International, Multi-Center, Prospective, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety and Efficacy of Nitric Oxide Synthase Inhibition With Tilarginine Acetate Injection in Patients With Cardiogenic Shock Complicating Acute Myocardial Infarction, or the TRIUMPH Trial
Study Type
Interventional
2. Study Status
Record Verification Date
May 2005
Overall Recruitment Status
Terminated
Study Start Date
May 2005 (undefined)
Primary Completion Date
undefined (undefined)
Study Completion Date
January 2007 (undefined)
3. Sponsor/Collaborators
Name of the Sponsor
Arginox Pharmaceuticals
4. Oversight
5. Study Description
Brief Summary
Tilarginine Acetate Injection is a new type of drug that temporarily stops the body from making a bodily substance called nitric oxide. The body may produce excess nitric oxide following severe heart damage leading to shock. During a heart attack, and especially after a blocked artery causing the heart attack is reopened, a large amount of nitric oxide is released into the heart muscle and into the blood. Normally small amounts of nitric oxide are good for the heart and blood vessels. However, when released in large amounts, such as during a heart attack, it may be harmful, by adding to the damage of the heart attack and lowering the heart's ability to pump blood to the body. It may cause blood pressure to be lowered and reduce the amount of blood flow to the body's vital organs. This may interfere with the body's organs being able to do their work. If Tilarginine Acetate Injection can stop extra nitric oxide from being made, the performance of the heart and blood flow to the organs may get better, which may result in the improvement of symptoms. The purpose of this study (TRIUMPH) is to investigate the safety and effectiveness of Tilarginine Acetate Injection compared to placebo (an inactive fluid that has no effect on the body but looks exactly like the medication being studied). The study will help determine whether Tilarginine Acetate Injection, by temporarily lowering the amount of nitric oxide released into the vital organs can improve blood pressure and the blood flow to the body's organs.
Detailed Description
An estimated 120,000 to 160,000 patients annually are diagnosed with cardiogenic shock (CS) in North America and Europe. CS complicates approximately 5-14% of all cases of acute myocardial infarction (AMI) and is the most common cause of death in patients hospitalized with AMI. Cardiogenic shock developing during the course of AMI is the end result of a pathophysiological cycle secondary to a sudden and significant decrease in cardiac contractility due to infarction, ischemia, and stunning of large myocardial segments. It is not anticipated that further advances in reperfusion or revascularization therapy will have a significant additional impact on survival in patients with CS. Modalities that protect the myocardium during ischemia and reperfusion are likely to be the next major advance in improving outcome in the setting of acute myocardial infarction (MI), especially in patients with large infarcts complicated by shock. Preliminary studies investigating nitric oxide synthase (NOS) inhibition suggest that improvements in cardiovascular function and survival are possible by limiting formation of toxic NO. The primary objective of the TRIUMPH study is to establish the efficacy of Tilarginine Acetate Injection compared to placebo in reducing all cause mortality at 30 days post randomization in patients with cardiogenic shock complicating acute myocardial infarction (MI). Safety objectives of this study include an evaluation of adverse events and serious adverse events, and key laboratory parameters.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Shock, Cardiogenic
Keywords
shock, cardiogenic, "myocardial infarction"
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
Double
Allocation
Randomized
Enrollment
658 (false)
8. Arms, Groups, and Interventions
Intervention Type
Drug
Intervention Name(s)
Tilarginine Acetate Injection intravenous infusion
Primary Outcome Measure Information:
Title
All cause mortality at 30 days post randomization
Secondary Outcome Measure Information:
Title
Number of patients demonstrating resolution of cardiogenic shock compared to placebo
Title
The duration of cardiogenic shock compared to placebo
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Confirmed myocardial infarction (heart attack)
Confirmed persistent cardiogenic shock
Confirmed patency of the infarct related artery (heart attack artery has been opened through the use of a blood clot dissolving drug or a balloon or angioplasty heart procedure)
Less than 24 hour duration of cardiogenic shock (the time since the heart attack occurred and the artery was opened must be less than 24 hours)
Exclusion Criteria:
Infection
Other cause of shock (not heart attack)
Shock due to heart valve disease
Severe heart valve disease
Right sided heart failure
Shock due to arrhythmia (irregular heart rhythm)
Severe kidney disease
Aortic dissection (tear in aorta)
Adult respiratory distress syndrome (ARDS) (severe lung inflammation)
Severe brain damage
Severe irreversible multi-system failure (failure of multiple body organs)
Major chest or abdominal surgical procedure within 30 days except if prior CABG and reocclusion occurs
Primary pulmonary hypertension (high blood pressure in the arteries of the lungs)
Age younger than 18 years
Requirement for emergency coronary artery bypass grafting (CABG) or infarct-related artery occlusion (heart attack artery completely blocked)
Ongoing or recent participation in another clinical trial of an investigational drug
Prior enrollment in this study or rapid resolution of cardiogenic shock before treatment (shock gets better before study starts)
Positive pregnancy test in women who are of childbearing potential
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Judith S. Hochman, M.D.
Organizational Affiliation
NYU Langone Health
Official's Role
Study Chair
Facility Information:
Facility Name
The Heart Group, PC
City
Mobile
State/Province
Alabama
ZIP/Postal Code
36608
Country
United States
Facility Name
Sparks Regional Medical Center
City
Fort Smith
State/Province
Arizona
ZIP/Postal Code
72901
Country
United States
Facility Name
Banner Baywood Heart Hospital
City
Mesa
State/Province
Arizona
ZIP/Postal Code
85206
Country
United States
Facility Name
Mayo Clinic Hospital
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85043
Country
United States
Facility Name
Central Arkansas Cardiovascular Research Group (CACRG)
City
Little Rock
State/Province
Arkansas
ZIP/Postal Code
72205
Country
United States
Facility Name
Los Angeles Cardiology Associates
City
Los Angeles
State/Province
California
ZIP/Postal Code
90017
Country
United States
Facility Name
University of Southern California, LAC + USC Medical Center
City
Los Angeles
State/Province
California
ZIP/Postal Code
90033
Country
United States
Facility Name
Cedars-Sinai Medical Center
City
Los Angeles
State/Province
California
ZIP/Postal Code
90048
Country
United States
Facility Name
Stanford University School of Medicine
City
Palo Alto
State/Province
California
ZIP/Postal Code
94305-5406
Country
United States
Facility Name
Desert Cardiology
City
Rancho Mirage
State/Province
California
ZIP/Postal Code
92270
Country
United States
Facility Name
Mercy General Hospital
City
Sacramento
State/Province
California
ZIP/Postal Code
95819
Country
United States
Facility Name
South Denver Cardiology Associates, PC
City
Littleton
State/Province
Colorado
ZIP/Postal Code
80120
Country
United States
Facility Name
Christiana Care Health Services
City
Newark
State/Province
Delaware
ZIP/Postal Code
19718
Country
United States
Facility Name
Washington Hospital Center
City
Washington
State/Province
District of Columbia
ZIP/Postal Code
20010-2975
Country
United States
Facility Name
Florida Cardiovascular Research Center
City
Atlantis
State/Province
Florida
ZIP/Postal Code
33462
Country
United States
Facility Name
Watson Clinic, LLP
City
Lakeland
State/Province
Florida
ZIP/Postal Code
33805
Country
United States
Facility Name
Health First Clinical Research Institute
City
Melbourne
State/Province
Florida
ZIP/Postal Code
32901
Country
United States
Facility Name
University of Miami School of Medicine
City
Miami
State/Province
Florida
ZIP/Postal Code
33136
Country
United States
Facility Name
Mt. Sinai Medical Center
City
Miami
State/Province
Florida
ZIP/Postal Code
33140
Country
United States
Facility Name
Mediquest Research Group
City
Ocala
State/Province
Florida
ZIP/Postal Code
34471
Country
United States
Facility Name
Orlando Regional Medical Center
City
Orlando
State/Province
Florida
ZIP/Postal Code
32806
Country
United States
Facility Name
Cardiovascular Center of Sarasota
City
Sarasota
State/Province
Florida
ZIP/Postal Code
34239
Country
United States
Facility Name
Emory Crawford Long Hospital
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30308
Country
United States
Facility Name
John H. Stroger Jr. Hospital of Cook County
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Facility Name
Heart Care Midwest
City
Peoria
State/Province
Illinois
ZIP/Postal Code
61603
Country
United States
Facility Name
Trinity Medical Center
City
Rock Island
State/Province
Illinois
ZIP/Postal Code
61201
Country
United States
Facility Name
Parkview Research Center
City
Fort Wayne
State/Province
Indiana
ZIP/Postal Code
46805
Country
United States
Facility Name
Iowa Health, Des Moines
City
Des Moines
State/Province
Iowa
ZIP/Postal Code
50309
Country
United States
Facility Name
Iowa Heart Centre
City
Des Moines
State/Province
Iowa
ZIP/Postal Code
50314
Country
United States
Facility Name
University of Iowa Hospital
City
Iowa City
State/Province
Iowa
ZIP/Postal Code
52242
Country
United States
Facility Name
University of Kansas Hospital
City
Kansas City
State/Province
Kansas
ZIP/Postal Code
66160
Country
United States
Facility Name
University of Kentucky
City
Lexington
State/Province
Kentucky
ZIP/Postal Code
40536-0200
Country
United States
Facility Name
Ochsner Clinic Foundation
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70121
Country
United States
Facility Name
Northeast Cardiology Associates
City
Bangor
State/Province
Maine
ZIP/Postal Code
04401
Country
United States
Facility Name
Maine Medical Center
City
Portland
State/Province
Maine
ZIP/Postal Code
04102
Country
United States
Facility Name
Brigham and Women's Hospital
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02115
Country
United States
Facility Name
Boston Medical Center
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02118
Country
United States
Facility Name
Beth Israel Deaconess Medical Center
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02215
Country
United States
Facility Name
Interventional Cardiovascular Research - Lahey Clinic
City
Burlington
State/Province
Massachusetts
ZIP/Postal Code
01805
Country
United States
Facility Name
University of Massachusetts Medical School
City
Worcester
State/Province
Massachusetts
ZIP/Postal Code
01655
Country
United States
Facility Name
Fallon Cardiology - St. Vincent Hospital
City
Worchester
State/Province
Massachusetts
ZIP/Postal Code
01608
Country
United States
Facility Name
University of Michigan Health Systems
City
Ann Arbor
State/Province
Michigan
ZIP/Postal Code
48109-0311
Country
United States
Facility Name
Henry Ford Hospital
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48202
Country
United States
Facility Name
Spectrum Health Hospitals
City
Grand Rapids
State/Province
Michigan
ZIP/Postal Code
49525
Country
United States
Facility Name
Nisus Research at Northern Michigan Hospital
City
Petoskey
State/Province
Michigan
ZIP/Postal Code
49770
Country
United States
Facility Name
William Beaumont Hospital
City
Royal Oak
State/Province
Michigan
ZIP/Postal Code
48073-6769
Country
United States
Facility Name
St. Mary's Duluth Clinic Health System
City
Duluth
State/Province
Minnesota
ZIP/Postal Code
55805
Country
United States
Facility Name
Mayo Clinic Minnesota
City
Rochester
State/Province
Minnesota
ZIP/Postal Code
55905
Country
United States
Facility Name
Saint Louis University
City
St. Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Facility Name
Washington University
City
St. Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Facility Name
BryanLGH Heart Institute
City
Lincoln
State/Province
Nebraska
ZIP/Postal Code
68516
Country
United States
Facility Name
University of Nebraska Medical Center
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68198-2265
Country
United States
Facility Name
Cooper Health System
City
Camden
State/Province
New Jersey
ZIP/Postal Code
08103
Country
United States
Facility Name
Newark Beth Israel Medical Center
City
Newark
State/Province
New Jersey
ZIP/Postal Code
07112
Country
United States
Facility Name
Lenox Hill Heart and Vascular Institute of New York
City
New York
State/Province
New York
ZIP/Postal Code
10021
Country
United States
Facility Name
Mount Sinai Medical Center
City
New York
State/Province
New York
ZIP/Postal Code
10029
Country
United States
Facility Name
Rochester Cardio-Pulmonary Group, P.C.
City
Rochester
State/Province
New York
ZIP/Postal Code
14621
Country
United States
Facility Name
University of Rochester Medical Center
City
Rochester
State/Province
New York
ZIP/Postal Code
14642
Country
United States
Facility Name
Cardiology Associates of Schenectady
City
Schenectady
State/Province
New York
ZIP/Postal Code
12309
Country
United States
Facility Name
Mission Hospitals
City
Asheville
State/Province
North Carolina
ZIP/Postal Code
28801
Country
United States
Facility Name
UNC Chapel Hill
City
Chapel Hill
State/Province
North Carolina
ZIP/Postal Code
27599-7075
Country
United States
Facility Name
Sanger Clinic
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28203
Country
United States
Facility Name
Duke University Medical Center
City
Durham
State/Province
North Carolina
ZIP/Postal Code
27710
Country
United States
Facility Name
LeBauer Cardiovascular Research
City
Greensboro
State/Province
North Carolina
ZIP/Postal Code
27401
Country
United States
Facility Name
Forsyth Medical Center
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27103
Country
United States
Facility Name
Cleveland Clinic Foundation
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44195
Country
United States
Facility Name
MidWest Cardiology Research Foundation
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43214
Country
United States
Facility Name
The Oregon Clinic
City
Portland
State/Province
Oregon
ZIP/Postal Code
97213-2281
Country
United States
Facility Name
Providence Heart & Vascular Institute
City
Portland
State/Province
Oregon
ZIP/Postal Code
97225
Country
United States
Facility Name
The Heart Care Group
City
Allentown
State/Province
Pennsylvania
ZIP/Postal Code
18106
Country
United States
Facility Name
Penn State Hershey Medical Center
City
Hershey
State/Province
Pennsylvania
ZIP/Postal Code
17033-0850
Country
United States
Facility Name
Lancaster General Hospital
City
Lancaster
State/Province
Pennsylvania
ZIP/Postal Code
17603
Country
United States
Facility Name
Allegheny General Hospital
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15212
Country
United States
Facility Name
Guthrie Clinic
City
Sayre
State/Province
Pennsylvania
ZIP/Postal Code
18830
Country
United States
Facility Name
The Miriam Hospital
City
Providence
State/Province
Rhode Island
ZIP/Postal Code
02906
Country
United States
Facility Name
South Carolina Heart Center
City
Columbia
State/Province
South Carolina
ZIP/Postal Code
29204
Country
United States
Facility Name
Johnson City Medical Center
City
Johnson City
State/Province
Tennessee
ZIP/Postal Code
37601
Country
United States
Facility Name
St. Thomas Cardiology Consultants
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37205
Country
United States
Facility Name
Ben Taub General Hospital, Baylor College of Medicine
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
The Methodist Hospital
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
University of Texas Medical School
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
LDS Hospital
City
Salt Lake City
State/Province
Utah
ZIP/Postal Code
84143
Country
United States
Facility Name
Fletcher Allen Healthcare
City
Burlington
State/Province
Vermont
ZIP/Postal Code
05401
Country
United States
Facility Name
Calgary Heart Centre Alberta
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2N 2T9
Country
Canada
Facility Name
Royal Alexandria Hospital
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T5H3V9
Country
Canada
Facility Name
University of Alberta
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T6G 2B7
Country
Canada
Facility Name
Vancouver Hospital and Health Sciences Centre
City
Vancouver
State/Province
British Columbia
ZIP/Postal Code
V5Z 1L8
Country
Canada
Facility Name
St. Paul's Hospital
City
Vancouver
State/Province
British Columbia
ZIP/Postal Code
V6Z 1Y6
Country
Canada
Facility Name
Victoria Heart Institute Foundation
City
Victoria
State/Province
British Columbia
ZIP/Postal Code
V8R 4R2
Country
Canada
Facility Name
St. Boniface General Hospital
City
Winnipeg
State/Province
Manitoba
ZIP/Postal Code
R2H 2A6
Country
Canada
Facility Name
NB Heart Centre
City
St. John
State/Province
New Brunswick
ZIP/Postal Code
E2L 4L2
Country
Canada
Facility Name
Cardiology Research - QEII Health Science Centre
City
Halifax
State/Province
Nova Scotia
ZIP/Postal Code
B3H 3A7
Country
Canada
Facility Name
QEII Health Science Centre - Cardiology Research
City
Halifax
State/Province
Nova Scotia
ZIP/Postal Code
B3H 3A7
Country
Canada
Facility Name
Hamilton Health Sciences, General Site
City
Hamilton
State/Province
Ontario
ZIP/Postal Code
L8L 2X2
Country
Canada
Facility Name
London Health Sciences Centre
City
London
State/Province
Ontario
ZIP/Postal Code
N6A 4G5
Country
Canada
Facility Name
Trilium Health Centre
City
Mississauga
State/Province
Ontario
ZIP/Postal Code
L5B 2P7
Country
Canada
Facility Name
Southlake Regional Health Centre
City
Newmarket
State/Province
Ontario
ZIP/Postal Code
L3Y 2R2
Country
Canada
Facility Name
University of Ottawa
City
Ottawa
State/Province
Ontario
ZIP/Postal Code
K1Y 4W7
Country
Canada
Facility Name
St. Michael's Hospital Toronto
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5B 1W8
Country
Canada
Facility Name
University Health Network - Toronto General Hospital
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5G 2C4
Country
Canada
Facility Name
Montreal Heart Institute
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H1T 1C8
Country
Canada
Facility Name
Quebec Heart Institute
City
Quebec
ZIP/Postal Code
G1V 4G5
Country
Canada
12. IPD Sharing Statement
Citations:
PubMed Identifier
17387132
Citation
TRIUMPH Investigators; Alexander JH, Reynolds HR, Stebbins AL, Dzavik V, Harrington RA, Van de Werf F, Hochman JS. Effect of tilarginine acetate in patients with acute myocardial infarction and cardiogenic shock: the TRIUMPH randomized controlled trial. JAMA. 2007 Apr 18;297(15):1657-66. doi: 10.1001/jama.297.15.joc70035. Epub 2007 Mar 26.
Results Reference
derived
Learn more about this trial
A Study of the Safety and Efficacy of Nitric Oxide Reduction in Patients With Cardiogenic Shock After a Heart Attack
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