Heart Disease in Sickle Cell Anemia
Sickle Cell Anemia, Pulmonary Hypertension
About this trial
This is an observational trial for Sickle Cell Anemia focused on measuring Cardiac Arrhythmias, Diastolic Dysfunction, Pulmonary Hypertension, Sickle Cell Anemia, Sudden Death, Thalassemia
Eligibility Criteria
INCLUSION CRITERIA FOR RIGHT HEART CATHETERIZATION AND STRESS ECHO: Either gender, aged greater than 18 years Diagnosis of sickle cell disease (electrophoretic documentation of SS, SC, or S Beta-thalassemia genotype is required) Hematocrit greater than 18 % (with an absolute reticulocyte count greater than 100,000/ml) EXCLUSION CRITERIA FOR RIGHT HEART CATHETERIZATION AND STRESS ECHO: Pregnancy or lactation Known or suspected coronary artery disease Hematocrit less than 18 %: will not be eligible for the study; may return for evaluation at a later date Significant renal insufficiency (patient on hemodialysis or estimated creatinine clearance less than 30% of normal Cerebrovascular accident within the last six weeks New diagnosis of pulmonary embolism within the last three months History of retinal detachment Patients with PAH known to be secondary to other causes, such as systemic lupus erythematosus, other collagen vascular diseases, valvular heart disease, congenital heart disease Poor echo windows Any other condition that would prevent participation in the study (for example HIV infection) INCLUSION CRITERIA FOR NON-INVASIVE PROCEDURES: Either gender, aged greater than 18 years Diagnosis of sickle cell disease (electrophoretic documentation of SS, SC, or S Beta-thalassemia genotype is required) EXCLUSION CRITERIA FOR NON-INVASIVE PROCEDURES: Pregnancy or lactation Known or suspected coronary artery disease Significant renal insufficiency (patient on hemodialysis or estimated creatinine clearance less than 30%of normal Cerebrovascular accident within the last six weeks New diagnosis of pulmonary embolism within the last three months History of retinal detachment Patients with PAH known to be secondary to other causes, such as systemic lupus erythematosus, other collagen vascular diseases, valvular heart disease, congenital heart disease Patients who are intolerant of MRI will not undergo cardiac MRI Any other condition that would prevent participation in the study (for example HIV infection)
Sites / Locations
- Suburban Hospital
- National Institutes of Health Clinical Center, 9000 Rockville Pike