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Cisplatin and Docetaxel With or Without Radiation Therapy in Treating Patients Who Are Undergoing Surgery for Newly Diagnosed Stage III Non-Small Cell Lung Cancer

Primary Purpose

Lung Cancer

Status
Terminated
Phase
Phase 3
Locations
United States
Study Type
Interventional
Intervention
filgrastim
pegfilgrastim
cisplatin
docetaxel
adjuvant therapy
conventional surgery
neoadjuvant therapy
radiation therapy
Sponsored by
Radiation Therapy Oncology Group
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Lung Cancer focused on measuring stage IIIA non-small cell lung cancer, adenocarcinoma of the lung, large cell lung cancer, squamous cell lung cancer, bronchoalveolar cell lung cancer

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

DISEASE CHARACTERISTICS: Histologically or cytologically confirmed primary non-small cell lung cancer (NSCLC)*, including any of the following cellular types: Adenocarcinoma Squamous cell carcinoma Large cell carcinoma Non-lobar and non-diffuse bronchoalveolar cell carcinoma NSCLC not otherwise specified NOTE: *Diagnosed within the past 3 months; diagnosis by mediastinal nodal biopsy or needle aspiration allowed provided a distinct lung primary (separate from the nodes) is clearly evident on CT scan Stage IIIA disease T1-T3 disease If pleural effusion is present, must meet ≥ 1 of the following criteria to exclude T4 disease: Pleural effusion cytologically negative by thoracentesis Documented absence of pleural metastases and pleural effusion cytologically negative by thoracoscopy (for patients with pleural effusion on CT scan [but not on chest x-ray] that is deemed too small to tap safely under either CT scan or ultrasound guidance) Confirmed positive ipsilateral mediastinal lymph node(s) (N2 disease)**, with or without positive ipsilateral hilar nodes, by mediastinoscopy, mediastinotomy, endoscopic ultrasound-guided transesophageal biopsy, thoracotomy, video-assisted thoracoscopy, Wang needles, or fine needle aspiration under bronchoscopic or CT guidance N2 nodes must be separate from primary tumor by CT scan or surgical exploration AND maximum diameter ≤ 3.0 cm Mediastinoscopy OR other means of mediastinal lymph node biopsy required (regardless of the primary tumor site) for patients with subcarinal lymphadenopathy by size criteria or by positron emission tomography (PET) scan If the lymph nodes in the contralateral mediastinum and neck are visible by contrast CT scan of the chest AND are ≥ 1.0 cm OR if contralateral involvement is suggested by PET scan, lymph nodes must be confirmed negative by one of the above diagnostic procedures AND N3 status must be confirmed negative by histology or cytology No palpable lymph nodes in the supraclavicular areas or higher in the neck unless proven benign by excisional biopsy A nodal biopsy or needle aspiration may be omitted provided all of the following criteria are true: Paralyzed left true vocal cord by bronchoscopy or indirect laryngoscopy Nodes visible in the aortopulmonary window (level 5) region on CT scan Distinct primary tumor (separate from the nodes) is visible by CT scan No evidence of subcarinal nodal involvement by CT scan NOTE: **PET scan positivity is not sufficient to establish N2 nodal status Measurable disease by chest x-ray and/or contrast-enhanced CT scan Candidate for surgery Resectable disease No distant metastases, including other ipsilateral or contralateral parenchymal lesions or liver or adrenal metastases, by history or physical examination, fludeoxyglucose F 18 PET scan, MRI or CT scan of the brain, chest x-ray and/or CT scan of the lungs and upper abdomen PATIENT CHARACTERISTICS: Age 18 and over Performance status Zubrod 0-1 Life expectancy Not specified Hematopoietic Absolute neutrophil count ≥ 1,800/mm^3 Platelet count ≥ 100,000/mm^3 Hemoglobin ≥ 10.0 g/dL (transfusion or other intervention allowed) Hepatic ALT and AST ≤ 2.5 times upper limit of normal (ULN) Alkaline phosphatase ≤ 2.5 times ULN Bilirubin ≤ 1.5 times ULN No hepatic insufficiency resulting in clinical jaundice or coagulation defects Renal Creatinine clearance ≥ 60 mL/min Cardiovascular No unstable angina or congestive heart failure requiring hospitalization within the past 6 months No transmural myocardial infarction within the past 6 months Pulmonary FEV_1 ≥ 2.0 L OR Predicted post-resection FEV_1 ≥ 0.8 L DLCO ≥ 50% of predicted No chronic obstructive pulmonary disease exacerbation No other respiratory illness requiring hospitalization or that would preclude study therapy Immunologic No AIDS No prior allergic reaction to the study drugs No history of severe hypersensitivity to other drugs formulated with polysorbate 80 No acute bacterial or fungal infection requiring IV antibiotics Other Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception No unintentional weight loss > 5% of body weight within the past 6 months No pre-existing peripheral neuropathy ≥ grade 2 No other invasive malignancy within the past 3 years except nonmelanoma skin cancer or carcinoma in situ of the breast, oral cavity, or cervix No other severe active comorbidity PRIOR CONCURRENT THERAPY: Biologic therapy No prior biological agent for this cancer No concurrent filgrastim (G-CSF), sargramostim (GM-CSF), or pegfilgrastim during study induction therapy (for patients randomized to the chemoradiotherapy arm) Chemotherapy No prior systemic chemotherapy for this cancer Prior chemotherapy for a different cancer allowed Endocrine therapy Not specified Radiotherapy No prior radiotherapy to the region of this cancer that would result in overlap of radiotherapy fields No routine post-operative radiotherapy No concurrent intensity modulated radiotherapy Surgery See Disease Characteristics Other No prior gefitinib for this cancer No concurrent amifostine

Sites / Locations

  • Cancer Center at Providence Alaska Medical Center
  • Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
  • Cancer Care Center at John Muir Health - Concord Campus
  • Moores UCSD Cancer Center
  • USC/Norris Comprehensive Cancer Center and Hospital
  • University of California Davis Cancer Center
  • Memorial Hospital
  • Front Range Cancer Specialists
  • Poudre Valley Hospital
  • CCOP - Christiana Care Health Services
  • Mayo Clinic - Jacksonville
  • Ella Milbank Foshay Cancer Center at Jupiter Medical Center
  • Watson Clinic, LLC
  • CCOP - Mount Sinai Medical Center
  • Phoebe Cancer Center at Phoebe Putney Memorial Hospital
  • CCOP - Atlanta Regional
  • Northeast Georgia Medical Center
  • Delnor Community Hospital - Geneva
  • Cardinal Bernardin Cancer Center at Loyola University Medical Center
  • Community Cancer Center
  • Advocate Christ Medical Center
  • Cancer Treatment Center at Pekin Hospital
  • Oncology Hematology Associates of Central Illinois, PC - Peoria
  • OSF St. Francis Medical Center
  • Cancer Institute at St. John's Hospital
  • Reid Hospital & Health Care Services, Incorporated
  • Memorial Hospital of South Bend
  • Hematology Oncology Associates of the Quad Cities
  • Genesis Regional Cancer Center at Genesis Medical Center
  • Markey Cancer Center at University of Kentucky Chandler Medical Center
  • St. Agnes Hospital Cancer Center
  • Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
  • Frederick Memorial Hospital Regional Cancer Therapy Center
  • Massachusetts General Hospital Cancer Center
  • CCOP - Michigan Cancer Research Consortium
  • University of Michigan Comprehensive Cancer Center
  • Bronson Methodist Hospital
  • Upper Michigan Cancer Center at Marquette General Hospital
  • Mayo Clinic Cancer Center
  • St. John's Regional Medical Center
  • St. John's Regional Health Center
  • Siteman Cancer Center at Barnes-Jewish Hospital
  • Good Samaritan Cancer Center at Good Samaritan Hospital
  • Methodist Cancer Center at Methodist Hospital - Omaha
  • UNMC Eppley Cancer Center at the University of Nebraska Medical Center
  • Valley Hospital - Ridgewood
  • NYU Cancer Institute at New York University Medical Center
  • SUNY Upstate Medical University Hospital
  • Faxton Regional Cancer Center
  • Duke Comprehensive Cancer Center
  • Leo W. Jenkins Cancer Center at ECU Medical School
  • Lenoir Memorial Cancer Center
  • FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center
  • Charles M. Barrett Cancer Center at University Hospital
  • Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University
  • Veterans Affairs Medical Center - Portland
  • Oregon Health & Science University Cancer Institute
  • St. Luke's Hospital Cancer Center
  • Penn State Cancer Institute at Milton S. Hershey Medical Center
  • Lancaster General Hospital
  • Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
  • Albert Einstein Cancer Center
  • Allegheny Cancer Center at Allegheny General Hospital
  • York Cancer Center at Apple Hill Medical Center
  • Hollings Cancer Center at Medical University of South Carolina
  • CCOP - Greenville
  • CCOP - Upstate Carolina
  • U.T. Cancer Institute at University of Tennessee Medical Center
  • Medical City Dallas Hospital
  • Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
  • CCOP - Virginia Mason Research Center
  • Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
  • Madigan Army Medical Center - Tacoma
  • Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
  • Dean Medical Center - Madison
  • Vince Lombardi Cancer Clinic - Sheboygan

Arms of the Study

Arm 1

Arm 2

Arm Type

Other

Other

Arm Label

Induction chemotherapy, surgery, consolidation chemotherapy

Chemotherapy and radiation, surgery, consolidation ch

Arm Description

Induction/surgery/consolidation

Induction/radiation/surgery/cosolidation

Outcomes

Primary Outcome Measures

Comparison of Overall Survival

Secondary Outcome Measures

Full Information

First Posted
June 7, 2005
Last Updated
June 21, 2013
Sponsor
Radiation Therapy Oncology Group
Collaborators
National Cancer Institute (NCI), SWOG Cancer Research Network, Cancer and Leukemia Group B, Eastern Cooperative Oncology Group, North Central Cancer Treatment Group
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1. Study Identification

Unique Protocol Identification Number
NCT00113386
Brief Title
Cisplatin and Docetaxel With or Without Radiation Therapy in Treating Patients Who Are Undergoing Surgery for Newly Diagnosed Stage III Non-Small Cell Lung Cancer
Official Title
Phase III Randomized Trial of Preoperative Chemotherapy Versus Preoperative Concurrent Chemotherapy and Thoracic Radiotherapy Followed by Surgical Resection and Consolidation Chemotherapy in Favorable Prognosis Patients With Stage IIIA (N2) Non-Small Cell Lung Cancer
Study Type
Interventional

2. Study Status

Record Verification Date
June 2013
Overall Recruitment Status
Terminated
Why Stopped
This study terminated early due to low accrual.
Study Start Date
April 2005 (undefined)
Primary Completion Date
February 2009 (Actual)
Study Completion Date
undefined (undefined)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Radiation Therapy Oncology Group
Collaborators
National Cancer Institute (NCI), SWOG Cancer Research Network, Cancer and Leukemia Group B, Eastern Cooperative Oncology Group, North Central Cancer Treatment Group

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
RATIONALE: Drugs used in chemotherapy, such as cisplatin and docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Cisplatin and docetaxel may make tumor cells more sensitive to radiation therapy. Giving more than one drug (combination chemotherapy) together with radiation therapy before surgery may shrink the tumor so it can be removed. Giving chemotherapy after surgery may kill any tumor cells that remain after surgery. It is not yet known whether giving cisplatin and docetaxel together with radiation therapy is more effective than giving cisplatin together with docetaxel in treating non-small cell lung cancer. PURPOSE: This randomized phase III trial is studying cisplatin, docetaxel, and radiation therapy to see how well they work compared to cisplatin and docetaxel in treating patients who are undergoing surgery for newly diagnosed stage III non-small cell lung cancer.
Detailed Description
OBJECTIVES: Primary Compare overall survival of patients with newly diagnosed favorable prognosis stage IIIA non-small cell lung cancer treated with neoadjuvant cisplatin and docetaxel with vs without thoracic conformal radiotherapy followed by surgical resection and docetaxel. Secondary Compare median and progression-free survival of patients treated with these regimens. Compare clinical and pathologic response rates in patients treated with these regimens. Compare the toxicity of these regimens in these patients. Correlate pathological complete response with disease-free and overall survival of patients treated with these regimens. Correlate DNA damage repair genes (ERCC1 and XRCC1), microtubule-related proteins (TUBB-III and MAP4), and shed tumor DNA with response and outcome in patients treated with these regimens. Correlate protein profiles, using MALDI-TOF proteomic analysis of tumor and serum, with response and prognosis in patients treated with these regimens. Compare quality of life of patients treated with these regimens. Determine the efficacy of fludeoxyglucose F 18 positron emission tomography scanning in assessing pathological response of the tumor and the mediastinal lymph nodes and in predicting long-term outcome in patients treated with these regimens. Correlate comorbid conditions with survival of patients treated with these regimens. OUTLINE: This is a randomized, multicenter study. Patients are stratified according to T stage (T1 vs T2-3), number of involved mediastinal lymph nodes (1 vs 2 or more vs not evaluable), and nodal micrometastases vs clinically involved nodes (mN2 vs cN2). Induction therapy: Patients are randomized to 1 of 2 treatment arms. Arm I: Patients receive cisplatin IV over 1 hour and docetaxel IV over 1 hour on days 1 and 22. Arm II: Patients undergo thoracic conformal radiotherapy once daily 5 days a week for approximately 5½ weeks (total of 28 doses). Patients also receive cisplatin IV over 1 hour on days 1, 8, 22, and 29 and docetaxel IV over 1 hour on days 1, 8, 15, 22, and 29. Surgery: Within 4-8 weeks after completion of induction therapy, patients with stable disease or better undergo a lobectomy or pneumonectomy with a formal systematic mediastinal lymph node dissection. Consolidation therapy: Beginning 4-6 weeks after surgery, patients receive docetaxel IV over 1 hour on days 1, 22, and 43 and pegfilgrastim or filgrastim (G-CSF) subcutaneously on days 2, 23, and 44. Quality of life is assessed at baseline, within 2 weeks after completion of induction therapy, and then at 6 and 12 months after surgery. After completion of study treatment, patients are followed every 3 months for 1 year, every 6 months for 2 years, and then annually thereafter. PROJECTED ACCRUAL: A total of 574 patients will be accrued for this study within 4 years.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Lung Cancer
Keywords
stage IIIA non-small cell lung cancer, adenocarcinoma of the lung, large cell lung cancer, squamous cell lung cancer, bronchoalveolar cell lung cancer

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
19 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Induction chemotherapy, surgery, consolidation chemotherapy
Arm Type
Other
Arm Description
Induction/surgery/consolidation
Arm Title
Chemotherapy and radiation, surgery, consolidation ch
Arm Type
Other
Arm Description
Induction/radiation/surgery/cosolidation
Intervention Type
Biological
Intervention Name(s)
filgrastim
Intervention Description
Consolidation chemotherapy
Intervention Type
Biological
Intervention Name(s)
pegfilgrastim
Intervention Description
Consolidation chemotherapy
Intervention Type
Drug
Intervention Name(s)
cisplatin
Intervention Type
Drug
Intervention Name(s)
docetaxel
Intervention Type
Procedure
Intervention Name(s)
adjuvant therapy
Intervention Type
Procedure
Intervention Name(s)
conventional surgery
Intervention Type
Procedure
Intervention Name(s)
neoadjuvant therapy
Intervention Type
Radiation
Intervention Name(s)
radiation therapy
Primary Outcome Measure Information:
Title
Comparison of Overall Survival
Time Frame
Date of death or date of last follow-up

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically or cytologically confirmed primary non-small cell lung cancer (NSCLC)*, including any of the following cellular types: Adenocarcinoma Squamous cell carcinoma Large cell carcinoma Non-lobar and non-diffuse bronchoalveolar cell carcinoma NSCLC not otherwise specified NOTE: *Diagnosed within the past 3 months; diagnosis by mediastinal nodal biopsy or needle aspiration allowed provided a distinct lung primary (separate from the nodes) is clearly evident on CT scan Stage IIIA disease T1-T3 disease If pleural effusion is present, must meet ≥ 1 of the following criteria to exclude T4 disease: Pleural effusion cytologically negative by thoracentesis Documented absence of pleural metastases and pleural effusion cytologically negative by thoracoscopy (for patients with pleural effusion on CT scan [but not on chest x-ray] that is deemed too small to tap safely under either CT scan or ultrasound guidance) Confirmed positive ipsilateral mediastinal lymph node(s) (N2 disease)**, with or without positive ipsilateral hilar nodes, by mediastinoscopy, mediastinotomy, endoscopic ultrasound-guided transesophageal biopsy, thoracotomy, video-assisted thoracoscopy, Wang needles, or fine needle aspiration under bronchoscopic or CT guidance N2 nodes must be separate from primary tumor by CT scan or surgical exploration AND maximum diameter ≤ 3.0 cm Mediastinoscopy OR other means of mediastinal lymph node biopsy required (regardless of the primary tumor site) for patients with subcarinal lymphadenopathy by size criteria or by positron emission tomography (PET) scan If the lymph nodes in the contralateral mediastinum and neck are visible by contrast CT scan of the chest AND are ≥ 1.0 cm OR if contralateral involvement is suggested by PET scan, lymph nodes must be confirmed negative by one of the above diagnostic procedures AND N3 status must be confirmed negative by histology or cytology No palpable lymph nodes in the supraclavicular areas or higher in the neck unless proven benign by excisional biopsy A nodal biopsy or needle aspiration may be omitted provided all of the following criteria are true: Paralyzed left true vocal cord by bronchoscopy or indirect laryngoscopy Nodes visible in the aortopulmonary window (level 5) region on CT scan Distinct primary tumor (separate from the nodes) is visible by CT scan No evidence of subcarinal nodal involvement by CT scan NOTE: **PET scan positivity is not sufficient to establish N2 nodal status Measurable disease by chest x-ray and/or contrast-enhanced CT scan Candidate for surgery Resectable disease No distant metastases, including other ipsilateral or contralateral parenchymal lesions or liver or adrenal metastases, by history or physical examination, fludeoxyglucose F 18 PET scan, MRI or CT scan of the brain, chest x-ray and/or CT scan of the lungs and upper abdomen PATIENT CHARACTERISTICS: Age 18 and over Performance status Zubrod 0-1 Life expectancy Not specified Hematopoietic Absolute neutrophil count ≥ 1,800/mm^3 Platelet count ≥ 100,000/mm^3 Hemoglobin ≥ 10.0 g/dL (transfusion or other intervention allowed) Hepatic ALT and AST ≤ 2.5 times upper limit of normal (ULN) Alkaline phosphatase ≤ 2.5 times ULN Bilirubin ≤ 1.5 times ULN No hepatic insufficiency resulting in clinical jaundice or coagulation defects Renal Creatinine clearance ≥ 60 mL/min Cardiovascular No unstable angina or congestive heart failure requiring hospitalization within the past 6 months No transmural myocardial infarction within the past 6 months Pulmonary FEV_1 ≥ 2.0 L OR Predicted post-resection FEV_1 ≥ 0.8 L DLCO ≥ 50% of predicted No chronic obstructive pulmonary disease exacerbation No other respiratory illness requiring hospitalization or that would preclude study therapy Immunologic No AIDS No prior allergic reaction to the study drugs No history of severe hypersensitivity to other drugs formulated with polysorbate 80 No acute bacterial or fungal infection requiring IV antibiotics Other Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception No unintentional weight loss > 5% of body weight within the past 6 months No pre-existing peripheral neuropathy ≥ grade 2 No other invasive malignancy within the past 3 years except nonmelanoma skin cancer or carcinoma in situ of the breast, oral cavity, or cervix No other severe active comorbidity PRIOR CONCURRENT THERAPY: Biologic therapy No prior biological agent for this cancer No concurrent filgrastim (G-CSF), sargramostim (GM-CSF), or pegfilgrastim during study induction therapy (for patients randomized to the chemoradiotherapy arm) Chemotherapy No prior systemic chemotherapy for this cancer Prior chemotherapy for a different cancer allowed Endocrine therapy Not specified Radiotherapy No prior radiotherapy to the region of this cancer that would result in overlap of radiotherapy fields No routine post-operative radiotherapy No concurrent intensity modulated radiotherapy Surgery See Disease Characteristics Other No prior gefitinib for this cancer No concurrent amifostine
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Maria Werner-Wasik, MD
Organizational Affiliation
Sidney Kimmel Cancer Center at Thomas Jefferson University
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Howard L. West, MD
Organizational Affiliation
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Jeffrey Crawford, MD
Organizational Affiliation
Duke Cancer Institute
Official's Role
Study Chair
First Name & Middle Initial & Last Name & Degree
Chandra P. Belani, MD
Organizational Affiliation
University of Pittsburgh
Official's Role
Study Chair
First Name & Middle Initial & Last Name & Degree
James R. Jett, MD
Organizational Affiliation
Mayo Clinic
Official's Role
Study Chair
Facility Information:
Facility Name
Cancer Center at Providence Alaska Medical Center
City
Anchorage
State/Province
Alaska
ZIP/Postal Code
99519-6604
Country
United States
Facility Name
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
City
Little Rock
State/Province
Arkansas
ZIP/Postal Code
72205
Country
United States
Facility Name
Cancer Care Center at John Muir Health - Concord Campus
City
Concord
State/Province
California
ZIP/Postal Code
94524-4110
Country
United States
Facility Name
Moores UCSD Cancer Center
City
La Jolla
State/Province
California
ZIP/Postal Code
92093-0658
Country
United States
Facility Name
USC/Norris Comprehensive Cancer Center and Hospital
City
Los Angeles
State/Province
California
ZIP/Postal Code
90089-9181
Country
United States
Facility Name
University of California Davis Cancer Center
City
Sacramento
State/Province
California
ZIP/Postal Code
95817
Country
United States
Facility Name
Memorial Hospital
City
Colorado Springs
State/Province
Colorado
ZIP/Postal Code
80909
Country
United States
Facility Name
Front Range Cancer Specialists
City
Fort Collins
State/Province
Colorado
ZIP/Postal Code
80524
Country
United States
Facility Name
Poudre Valley Hospital
City
Fort Collins
State/Province
Colorado
ZIP/Postal Code
80524
Country
United States
Facility Name
CCOP - Christiana Care Health Services
City
Newark
State/Province
Delaware
ZIP/Postal Code
19713
Country
United States
Facility Name
Mayo Clinic - Jacksonville
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32224
Country
United States
Facility Name
Ella Milbank Foshay Cancer Center at Jupiter Medical Center
City
Jupiter
State/Province
Florida
ZIP/Postal Code
33458
Country
United States
Facility Name
Watson Clinic, LLC
City
Lakeland
State/Province
Florida
ZIP/Postal Code
33804-5000
Country
United States
Facility Name
CCOP - Mount Sinai Medical Center
City
Miami Beach
State/Province
Florida
ZIP/Postal Code
33140
Country
United States
Facility Name
Phoebe Cancer Center at Phoebe Putney Memorial Hospital
City
Albany
State/Province
Georgia
ZIP/Postal Code
31701
Country
United States
Facility Name
CCOP - Atlanta Regional
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30342
Country
United States
Facility Name
Northeast Georgia Medical Center
City
Gainesville
State/Province
Georgia
ZIP/Postal Code
30501
Country
United States
Facility Name
Delnor Community Hospital - Geneva
City
Geneva
State/Province
Illinois
ZIP/Postal Code
60134
Country
United States
Facility Name
Cardinal Bernardin Cancer Center at Loyola University Medical Center
City
Maywood
State/Province
Illinois
ZIP/Postal Code
60153
Country
United States
Facility Name
Community Cancer Center
City
Normal
State/Province
Illinois
ZIP/Postal Code
61761
Country
United States
Facility Name
Advocate Christ Medical Center
City
Oak Lawn
State/Province
Illinois
ZIP/Postal Code
60453-2699
Country
United States
Facility Name
Cancer Treatment Center at Pekin Hospital
City
Pekin
State/Province
Illinois
ZIP/Postal Code
61554
Country
United States
Facility Name
Oncology Hematology Associates of Central Illinois, PC - Peoria
City
Peoria
State/Province
Illinois
ZIP/Postal Code
61615
Country
United States
Facility Name
OSF St. Francis Medical Center
City
Peoria
State/Province
Illinois
ZIP/Postal Code
61637
Country
United States
Facility Name
Cancer Institute at St. John's Hospital
City
Springfield
State/Province
Illinois
ZIP/Postal Code
62702
Country
United States
Facility Name
Reid Hospital & Health Care Services, Incorporated
City
Richmond
State/Province
Indiana
ZIP/Postal Code
47374
Country
United States
Facility Name
Memorial Hospital of South Bend
City
South Bend
State/Province
Indiana
ZIP/Postal Code
46601
Country
United States
Facility Name
Hematology Oncology Associates of the Quad Cities
City
Bettendorf
State/Province
Iowa
ZIP/Postal Code
52722
Country
United States
Facility Name
Genesis Regional Cancer Center at Genesis Medical Center
City
Davenport
State/Province
Iowa
ZIP/Postal Code
52803
Country
United States
Facility Name
Markey Cancer Center at University of Kentucky Chandler Medical Center
City
Lexington
State/Province
Kentucky
ZIP/Postal Code
40536-0293
Country
United States
Facility Name
St. Agnes Hospital Cancer Center
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21229
Country
United States
Facility Name
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21231-2410
Country
United States
Facility Name
Frederick Memorial Hospital Regional Cancer Therapy Center
City
Frederick
State/Province
Maryland
ZIP/Postal Code
21701
Country
United States
Facility Name
Massachusetts General Hospital Cancer Center
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02114
Country
United States
Facility Name
CCOP - Michigan Cancer Research Consortium
City
Ann Arbor
State/Province
Michigan
ZIP/Postal Code
48106
Country
United States
Facility Name
University of Michigan Comprehensive Cancer Center
City
Ann Arbor
State/Province
Michigan
ZIP/Postal Code
48109-0942
Country
United States
Facility Name
Bronson Methodist Hospital
City
Kalamazoo
State/Province
Michigan
ZIP/Postal Code
49007
Country
United States
Facility Name
Upper Michigan Cancer Center at Marquette General Hospital
City
Marquette
State/Province
Michigan
ZIP/Postal Code
49855
Country
United States
Facility Name
Mayo Clinic Cancer Center
City
Rochester
State/Province
Minnesota
ZIP/Postal Code
55905
Country
United States
Facility Name
St. John's Regional Medical Center
City
Joplin
State/Province
Missouri
ZIP/Postal Code
64804
Country
United States
Facility Name
St. John's Regional Health Center
City
Springfield
State/Province
Missouri
ZIP/Postal Code
65804
Country
United States
Facility Name
Siteman Cancer Center at Barnes-Jewish Hospital
City
St Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Facility Name
Good Samaritan Cancer Center at Good Samaritan Hospital
City
Kearney
State/Province
Nebraska
ZIP/Postal Code
68848-1990
Country
United States
Facility Name
Methodist Cancer Center at Methodist Hospital - Omaha
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68114
Country
United States
Facility Name
UNMC Eppley Cancer Center at the University of Nebraska Medical Center
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68198-6805
Country
United States
Facility Name
Valley Hospital - Ridgewood
City
Ridgewood
State/Province
New Jersey
ZIP/Postal Code
07450
Country
United States
Facility Name
NYU Cancer Institute at New York University Medical Center
City
New York
State/Province
New York
ZIP/Postal Code
10016
Country
United States
Facility Name
SUNY Upstate Medical University Hospital
City
Syracuse
State/Province
New York
ZIP/Postal Code
13210
Country
United States
Facility Name
Faxton Regional Cancer Center
City
Utica
State/Province
New York
ZIP/Postal Code
13502
Country
United States
Facility Name
Duke Comprehensive Cancer Center
City
Durham
State/Province
North Carolina
ZIP/Postal Code
27710
Country
United States
Facility Name
Leo W. Jenkins Cancer Center at ECU Medical School
City
Greenville
State/Province
North Carolina
ZIP/Postal Code
27835-6028
Country
United States
Facility Name
Lenoir Memorial Cancer Center
City
Kinston
State/Province
North Carolina
ZIP/Postal Code
28501
Country
United States
Facility Name
FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center
City
Pinehurst
State/Province
North Carolina
ZIP/Postal Code
28374
Country
United States
Facility Name
Charles M. Barrett Cancer Center at University Hospital
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45267
Country
United States
Facility Name
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43210-1240
Country
United States
Facility Name
Veterans Affairs Medical Center - Portland
City
Portland
State/Province
Oregon
ZIP/Postal Code
97207
Country
United States
Facility Name
Oregon Health & Science University Cancer Institute
City
Portland
State/Province
Oregon
ZIP/Postal Code
97239-3098
Country
United States
Facility Name
St. Luke's Hospital Cancer Center
City
Bethlehem
State/Province
Pennsylvania
ZIP/Postal Code
18015
Country
United States
Facility Name
Penn State Cancer Institute at Milton S. Hershey Medical Center
City
Hershey
State/Province
Pennsylvania
ZIP/Postal Code
17033-0850
Country
United States
Facility Name
Lancaster General Hospital
City
Lancaster
State/Province
Pennsylvania
ZIP/Postal Code
17604
Country
United States
Facility Name
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19107-5541
Country
United States
Facility Name
Albert Einstein Cancer Center
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19141
Country
United States
Facility Name
Allegheny Cancer Center at Allegheny General Hospital
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15212
Country
United States
Facility Name
York Cancer Center at Apple Hill Medical Center
City
York
State/Province
Pennsylvania
ZIP/Postal Code
17405
Country
United States
Facility Name
Hollings Cancer Center at Medical University of South Carolina
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29425
Country
United States
Facility Name
CCOP - Greenville
City
Greenville
State/Province
South Carolina
ZIP/Postal Code
29615
Country
United States
Facility Name
CCOP - Upstate Carolina
City
Spartanburg
State/Province
South Carolina
ZIP/Postal Code
29303
Country
United States
Facility Name
U.T. Cancer Institute at University of Tennessee Medical Center
City
Knoxville
State/Province
Tennessee
ZIP/Postal Code
37920-6999
Country
United States
Facility Name
Medical City Dallas Hospital
City
Dallas
State/Province
Texas
ZIP/Postal Code
75230
Country
United States
Facility Name
Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
City
Dallas
State/Province
Texas
ZIP/Postal Code
75390
Country
United States
Facility Name
CCOP - Virginia Mason Research Center
City
Seattle
State/Province
Washington
ZIP/Postal Code
98101
Country
United States
Facility Name
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
City
Seattle
State/Province
Washington
ZIP/Postal Code
98122-4307
Country
United States
Facility Name
Madigan Army Medical Center - Tacoma
City
Tacoma
State/Province
Washington
ZIP/Postal Code
98431
Country
United States
Facility Name
Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
City
Green Bay
State/Province
Wisconsin
ZIP/Postal Code
54311
Country
United States
Facility Name
Dean Medical Center - Madison
City
Madison
State/Province
Wisconsin
ZIP/Postal Code
53717
Country
United States
Facility Name
Vince Lombardi Cancer Clinic - Sheboygan
City
Sheboygan
State/Province
Wisconsin
ZIP/Postal Code
53081
Country
United States

12. IPD Sharing Statement

Learn more about this trial

Cisplatin and Docetaxel With or Without Radiation Therapy in Treating Patients Who Are Undergoing Surgery for Newly Diagnosed Stage III Non-Small Cell Lung Cancer

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