SYNTAX Study: TAXUS Drug-Eluting Stent Versus Coronary Artery Bypass Surgery for the Treatment of Narrowed Arteries (SYNTAX)
Coronary Artery Disease
About this trial
This is an interventional treatment trial for Coronary Artery Disease focused on measuring Three-vessel coronary artery disease, Left main coronary artery disease
Eligibility Criteria
Inclusion Criteria: Three-vessel disease, left main disease or LM equivalent with or without 1, 2 or 3VD (left anterior descending [LAD], left circumflex [LCX], right coronary artery [RCA] territory) De novo lesions with at least 50% stenosis Myocardial ischemia (stable, unstable, silent) Exclusion Criteria: Prior PCI or CABG Acute myocardial infarction (with creatinine kinase >2x upper limit of normal) Concomitant cardiac valve disease requiring surgical therapy (reconstruction or replacement) Participation or planned participation in another cardiovascular clinical study before 1 year follow-up is completed Inability to give informed consent due to mental condition, mental retardation, or language barrier
Sites / Locations
- Mercy General Hospital
- Washington Hospital Center
- Florida Cardiovascular Research
- Munroe Medical Center
- Ocala Heart Institue
- Florida Hospital
- Evanston Hospital
- Rockford Cardiology Research Foundation (St. Anthony's Medical Center)
- University of Iowa Hospital and Clinics
- Maine Medical Center
- Tufts New England Medical Center
- Cape Cod Hospital
- Cape Cod Research Institute
- Genesys Regional Medical Center
- Spectrum Health
- Cardiac & Vascular Research Center of Northern Michigan
- Abbott Northwestern Hospital
- Mayo Clinic
- St. Mary's Hospital
- SUNY - Stony Brook School of Medicine
- SJH Cardiology Associates
- St. Joseph's Hospital Health Center
- LeBauer Cardiovascular Research Foundation
- Cardiovascular and Thoracic Surgeons of Greensboro
- Wake Medical Center
- Forsyth Medical Center
- Oklahoma Foundation for Cardiovascular Research
- St. Mary's Medical Center
- Medical City Dallas Hospital
- Baylor University Medical Center
- San Antonio Endovascular Heart Institue
- Sentara Norfolk General Hospital 1st Fl
- Univ. Klinik für Herzchirurgie Landeskliniken
- Allgemeines Krankenhaus AKH
- Onze Lieve Vrouw Ziekenhuis
- Academisch Ziekenhuis Middelheim
- Universitair Ziekenhuis
- Centre Hôpital Universitaire Sart Tilman
- University Hospital Vinohrady
- Interni Klinika VFN
- Skejby Sygehus
- Helsinki University Central Hospital
- University of Helsinki Meilahti Hospital
- Clinique St Augustin
- Institut Cardiovasculaire Paris Sud - Massy
- Centre Hopital Universitaire Rouen - Hopital Charles Nicolle
- Clinique Saint-Hilaire Rouen
- CHU Rangueil
- Clinique Pasteur
- Centre Hôpital Universitaire Rangueil
- Herz- und Diabeteszentrum Nordrhein-Westfalen
- Universitatsklinik Charite Berlin, Campus Mitte
- Campus Virchow Klinikum Herzkatheterlabor
- Charite Universitaetsmedizin Berlin, Campus Virchow Klinikum
- Universitätsklinik Freiburg
- Universitatsklinikum Hamburg Eppendorf
- Universitätsklinikum Campus Kiel
- Universitätsklinikum Schleswig-Holstein Campus Kiel
- Herzzentrum Universität Leipzig
- Medizinische Universitaet Luebeck
- Klinikum Grosshadern
- Krankenhaus der Barmherzigen Brüder
- National Medical Center
- University of Debrecen, Medical and Health Science Center
- Medical School of University PECS
- Ospedale Riuniti di Bergamo
- Istituto di Fisiologia Clinica, Stabilimento di Massa Ospedale
- Ospedale San Raffaele
- Ospedale Civile di Mirano
- IRCCS Policlinico S. Matteo
- Policlinico San Matteo
- Policlinico Agostino Gemelli
- Istituto Clinico Humanitas
- P. Stradins University Hospital
- Amphia Ziekenhuis
- Catharina Ziekenhuis
- Academisch Ziekenhuis Groningen
- St. Antonius Hospital
- Erasmus MC - University Medical Center Rotterdam
- Isala Klinieken, De Weezenlanden
- Rikshospitalet
- Medical University of Silesia - Katowice
- John Paul II Hospital
- Jagiellonian University of Cardiology
- National Institute of Cardiology
- Hospital de Santa Marta
- Hospital General de Alicante
- Hospital General Universitario
- Hospital Clinico Y Provincial
- Hospital Clinico San Carlos
- Hospital Clinico Salamanca
- Sahlgrenska University Hospital
- University Hospital of Lund
- Lund University Hospital
- Karolinska Universitets Sjukhuset - Stockholm
- Akademiska sjukhuset
- University Hospital Uppsala
- Royal Sussex County Hospital
- Western Infirmary
- Glenfield Hospital
- University Hospitals of Leicester NHS Trust Glenfield Hospital
- London Chest Hospital
- St Thomas Hospital
- King's College Hospital London
- John Radcliffe Infirmary Oxford II
- Southampton University Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
PCI with DES
CABG (coronary artery bypass graft)
Coronary Artery Bypass Graft