Evaluation of GW406381 in Treating Adults With Osteoarthritis Of The Knee
Osteoarthritis, Knee
About this trial
This is an interventional treatment trial for Osteoarthritis, Knee focused on measuring COX-2 inhibitor, Knee osteoarthritis
Eligibility Criteria
Inclusion criteria: Subjects have a primary diagnosis of osteoarthritis of the knee with symptom duration of at least 3 months. Use pain medication, such as a COX-2 inhibitor or NSAID (non-steroidal anti-inflammatory drug) at least 5 days per week. Exclusion criteria: History of hypersensitivity or intolerance to pain medications. History of gastroduodenal perforations and/or obstructions. History of upper GI (gastrointestinal) ulceration within the previous 6 months. History of upper or lower GI bleeding within the previous year. History of inflammatory bowel disease. Currently take sucralfate or misoprostol. Currently taking aspirin daily for the heart. Other restrictions around the use medications apply and would need to be discussed. History of coronary artery disease, (angina, MI) or surgery. History of congestive heart failure or renal artery stenosis. History of stroke or transient ischemic attack. History of uncontrolled hypertension.
Sites / Locations
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site