Safety of and Immune Response to an Adenoviral HIV Vaccine (VRC-HIVADV014-00-VP) With or Without a Plasmid HIV Vaccine (VRC-HIVDNA016-00-VP) in HIV Uninfected Adults

Inclusion Criteria: Willing to follow all the requirements of the study and available for follow-up for the duration of the study Have understanding of the study and provide written informed consent Willing to undergo HIV testing and counseling and willing to receive HIV test results Willing to use acceptable forms of contraception Exclusion Criteria: HIV infected Hepatitis B virus infected Hepatitis C virus infected Active or untreated syphilis Participated in high-risk behavior for HIV infection within 6 months prior to study entry. More information on this criterion can be found in the protocol. Any clinically significant abnormality in history or upon examination (e.g., immunodeficiency or autoimmune disease; use of systemic corticosteroids, immunosuppressive, antiviral, anticancer, or other medications considered significant by the investigator) within 6 months prior to study entry Any clinically significant acute or chronic medical condition that, in the opinion of the investigator, would make the volunteer unsuitable for the study Live attenuated vaccines within 30 days prior to study entry OR plan to receive a live attenuated vaccine within 60 days after vaccination in this study Subunit or killed vaccines within 14 days prior to study entry OR plan to receive a subunit or killed vaccine within 14 days after vaccination in this study Blood transfusion or blood products within 120 days prior to study entry Immunoglobulin within 60 days prior to study entry Participation in another investigational product clinical trial in the 3 months prior to study entry OR expected to participate in another investigational trial during this study Any other investigational HIV vaccine at any time History of severe local or systemic reactogenicity to vaccines or history of severe allergic reactions Major psychiatric illness, including any history of schizophrenia or severe psychosis, bipolar disorder requiring therapy, or suicide attempt or suicidal thoughts within the 3 years prior to study entry Uncontrolled hypertension Pregnant, breastfeeding, or plan to become pregnant