Concurrent Chemoradiation Versus Surgery With Adjuvant Therapy in Advanced Laryngopharyngeal Cancers
Larynx Neoplasms
About this trial
This is an interventional treatment trial for Larynx Neoplasms focused on measuring neoplasm, larynx, surgery, radiotherapy, chemotherapy
Eligibility Criteria
Inclusion Criteria: Patients with biopsy-proven, previously untreated, T3/T4 tumors (with focal cartilage erosion on computed tomography [CT] scan); squamous cell carcinoma of larynx and hypopharynx. Patients with Karnofsky Performance Scale (KPS) > 80 Patients must have resectable tumors which are potentially curable with conventional surgery and radiation therapy. Willing to participate in trial and get randomized Exclusion Criteria: Gross cartilage invasion Extensive soft tissue infiltration Large nodal disease Distant metastases Synchronous primary
Sites / Locations
- Tata Memorial Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
1
2
Concurrent Chemoradiation
Laryngectomy + adjuvant radiotherapy/chemoradiotherapy