RCT ALB for SA Cysticercosis
Subarachnoid Cysticercosis

About this trial
This is an interventional treatment trial for Subarachnoid Cysticercosis focused on measuring Albenza, Subarachnoid cysticercosis
Eligibility Criteria
Inclusion Criteria: Male or female individuals between 18-65 year of age with a diagnosis of basal subarachnoid cysticercosis, based on MRI and confirmed by serological test. Willingness to accomplish the two weeks minimal hospitalization required. Female of child-bearing potential willing to use an adequate method of contraception including implants, injectables, combined oral contraceptives, effective intrauterine devices, sexual abstinence, or vasectomized partner while participating in the study. Patients with normal laboratory values for hemoglobin, platelet counts, total white blood cells, glucose, creatinine, bilirubin, ALT, AST, and electrolytes. Negative fecal exam for Taenia eggs. Exclusion Criteria: Previous therapy with albendazole (does not include patients who received single-dose 400 mg ABZ for intestinal parasites), or praziquantel. Pulmonary tuberculosis evidenced by a positive chest X-ray and positive sputum smears. Pre-existing diagnosis of diabetes Systemic disease other than NCC that may affect therapy or short-term prognosis, including but not limited to chronic renal failure, hepatic insufficiency, cardiac failure, and steroid-dependent immune diseases. Identification of systemic diseases will be left to the discretion of each Site PI. Patients in unstable condition or with severe intracranial hypertension (ICH). Definition of severe ICH for this study would be the presence of headaches, nausea, and vomiting and papilledema at fundoscopic examination (all of them). Patients in this category can be considered for entrance into the study only after treatment of ICH by ventricle-peritoneal shunting. Patients with CT findings compatible with intracranial hypertension will have neurosurgical evaluation (by non study personal) before study entry. Pregnancy History of hypersensitivity to albendazole Concurrent treatment with praziquantel, cimetidine or teophylline. Chronic alcohol or drug abuse
Sites / Locations
- Facultad de Medicina de Riberao
- Instituto Neurologico de Antioquia
- Neurology Service, Hospital -Clinica Kennedy
- Universidad Peruana Cayetano Heredia