Rituximab and Cyclophosphamide Followed by Vaccine Therapy in Treating Patients With Relapsed Hodgkin Lymphoma
Lymphoma
About this trial
This is an interventional treatment trial for Lymphoma focused on measuring recurrent adult Hodgkin lymphoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed classical Hodgkin's lymphoma Relapsed disease with achievement of at least a partial response or a metabolic response to most recent salvage therapy No primary induction failure, defined as disease progression during or within 2 months after completion of first-line therapy PATIENT CHARACTERISTICS: Age 18 and over Performance status ECOG 0-1 Life expectancy Not specified Hematopoietic Absolute neutrophil count ≥ 1,000/mm^3 Platelet count ≥ 75,000/mm^3 Hepatic Bilirubin ≤ 2.0 mg/dL* NOTE: *Unless due to lymphoma or Gilbert's syndrome Renal Creatinine ≤ 2.0 mg/dL Cardiovascular Ejection fraction ≥ 45% by echocardiogram or MUGA Pulmonary DLCO ≥ 50% of predicted (corrected for alveolar volume) Immunologic No known HIV positivity No active infection requiring oral or IV antibiotics No autoimmune or other disease requiring long-term systemic steroids or other long-term immunosuppressants Other Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception Able to tolerate high-dose therapy No other malignancy within the past 3 years except basal cell or squamous cell skin cancer or carcinoma in situ of the cervix PRIOR CONCURRENT THERAPY: Biologic therapy Not specified Chemotherapy No prior bone marrow transplantation Endocrine therapy Not specified Radiotherapy Concurrent radiotherapy for disease progression after high-dose cyclophosphamide allowed at the discretion of the principal investigator Surgery Not specified
Sites / Locations
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Arms of the Study
Arm 1
Experimental
Immunotherapy
All participants received two days of rituximab, then four days of high-dose cyclophosphamide followed by filgrastim. Participants then received six doses of KGEL vaccine over 24 weeks interspersed with four additional doses of rituximab.