Endothelial Modulation for Angiogenic Therapy
Coronary Artery Disease
About this trial
This is an interventional treatment trial for Coronary Artery Disease focused on measuring Coronary Artery Disease, Diffuse, Coronary Artery Disease, Deemed Inoperable
Eligibility Criteria
Inclusion Criteria: Severe chronic angina Multi-vessel coronary artery disease Diffusely diseased left anterior descending coronary artery (LAD) At least 18 years of age at the time of written informed consent Exclusion Criteria: Pregnancy, lactation, or any child-bearing potential Patients who are candidates for percutaneous transluminal coronary angioplasty (PTCA) or stenting Severe left ventricular dysfunction (ejection fraction < 30%) Threatened proximal coronary occlusion or unstable angina Recent myocardial infarction (< 1 month) Chronic renal failure (serum creatinine > 130 µmol/L) Hepatic insufficiency (Child-Pugh Class C) Clinically significant valvular heart disease Personal history of neoplasia Abnormal serum prostate-specific antigen (PSA), bowel neoplasia screening questionnaire, or updated mammography report (if female) - any test not performed within the last 6 months will be conducted prior to confirmation of eligibility Family history of cancer (i.e. ≥ 2 first-degree relatives) History of diabetic retinopathy Latent herpes infection Schizophrenia Claustrophobia
Sites / Locations
- Division of Cardiac Surgery, University of Ottawa Heart Institute