Effectiveness of Memantine in Treating Cocaine-Dependent Individuals - 2
Cocaine-Related Disorders
About this trial
This is an interventional treatment trial for Cocaine-Related Disorders focused on measuring Cocaine dependence, treatment, memantine
Eligibility Criteria
Inclusion Criteria: Meets DSM-IV criteria for current cocaine dependence Use of cocaine at least four days in the month prior to enrollment or episodic cocaine binges of at least $200 worth at least twice each month (confirmed by urine toxicology test) Exclusion Criteria: Meets DSM-IV criteria for major depression, bipolar disorder, schizophrenia, or any psychotic disorder other than transient psychosis due to drug abuse History of seizures in the two years prior to enrollment History of seizures related to current substance abuse (including cocaine, alcohol, or benzodiazepine) History of an allergic reaction to memantine Chronic organic mental disorder Current significant suicidal risk, history of significant suicidal behavior, or any suicide attempt within the year prior to enrollment Pregnant or breastfeeding Failure to use adequate contraception Unstable physical disorders that might make participation hazardous, such as hypertension, acute hepatitis (individuals with chronic mildly elevated transaminase levels at 2 to 3 times the upper normal limit are not excluded if their PT/PTT is normal), renal impairment, or diabetes Current coronary vascular disease, or suspected by an abnormal ECG or history of cardiac symptoms Cardiac conduction system disease, as indicated by QRS duration greater than 0.11 History of failure to respond to a previous trial with memantine Currently meets DSM-IV criteria for substance dependence or abuse disorder other than nicotine or marijuana Currently taking psychotropic medications, excluding zolpidem or trazodone for insomnia
Sites / Locations
- Research Foundation for Mental Hygiene, Inc.
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Memantine
Placebo
Memantine
Placebo