A Trial of Taurine Supplementation in Parenteral Nutrition 1
Cholestasis
About this trial
This is an interventional prevention trial for Cholestasis focused on measuring taurine, intestinal failure, HPN, hepatobiliary complications, chronic intestinal failure (CIF)
Eligibility Criteria
Inclusion Criteria: Chronic intestinal failure (CIF) patients on long term home parenteral nutrition, under the care of the Nutrition and Intestinal Failure Clinic at St Mark's, who have PNAC. Must be over 18 On HPN for 6 months and stable Life expectancy of over 12 months HPN should provide > 75-80% of estimated nutritional requirements Should be on HPN for 5 or more days per week Exclusion Criteria: No consent. Pregnancy/lactation. Planned surgery. Renal failure. Hepatitic failure, ultrasound proven fibrosis or cirrhosis, poorly controlled diabetes, hepatitis B or C, autoimmune liver disease, receiving > 40 kcal/kg/day from HPN, current sepsis, co-existing surgical complications such as intestinal obstruction, hepatotoxic drugs, primary liver cancer or metastases or any other cause for pre and post hepatic jaundice. Inability to adhere to the protocol.
Sites / Locations
- North West London NHS Trust - St Mark's HospitalRecruiting