Endobronchial Valve for Emphysema PalliatioN Trial (VENT) Cost-effectiveness Sub-Study
Emphysema, Chronic Obstructive Pulmonary Disease
About this trial
This is an interventional treatment trial for Emphysema focused on measuring Endobronchial Valve, Endobronchial Valve ProcedureEBV, EBV Procedure, Endobronchial Lung Volume Reduction, Lung Volume Reduction
Eligibility Criteria
Inclusion Criteria: Diagnosed by high-resolution computed tomography (HRCT) with eligible heterogeneous disease distribution Forced expiratory volume in 1 second (FEV1) < 45% predicted Total lung capacity (TLC) > 100% predicted Residual volume (RV) > 150% predicted Post rehabilitation 6 minute walk test > 140m Non-smoking for 4 months Exclusion Criteria: Prior lung transplant, lung volume reduction surgery (LVRS), median sternotomy, bullectomy or lobectomy History of recurrent respiratory infections Evidence of large bullae (> 30% of either lung) in a non-target lobe FEV1 < 15% predicted Diffusing capacity of the lung for carbon monoxide (DLCO) < 20% predicted