Brain Activity Associated With Tics in Patients With Tourette Syndrome
Tourette Syndrome
About this trial
This is an observational trial for Tourette Syndrome focused on measuring Sensory Processing, Magnetoencephalogram, Tourete Syndrome, Trigeminal Nerve, Tics, TS, Healthy Volunteer, HV
Eligibility Criteria
INCLUSION CRITERIA FOR NORMAL VOLUNTEERS: Subjects will be normal volunteers with no history of neurological disorders; they will be screened in the NINDS Movement Disorders Outpatient Clinic, and will have a neurological and physical examination. Subjects will be male or female, in age ranges 14 to 65 years old. INCLUSION CRITERIA FOR PATIENTS: Patients ages 14 to 65 with a clinical diagnosis of tourette syndrome or chronic motor tic disorder as defined by DSM-IV-TR and evaluation of tic severity using the Yale Tic Scale (YGTSS). This criterion will be established by preliminary screening in the NINDS Movement Disorders Outpatient Clinic. Structure Clinical Interview for (DSMIV SCID) will be administered to all subjects to ensure that strict DSM-IV criteria for Tourette syndrome have been met and to assess for possible comorbid psychiatric disorders. Patients with at least moderate premonitory urge, as evaluated with the PUTS. Patients with sensory tics, either bilaterally or unilaterally, in the facial region. EXCLUSION CRITERIA FOR PATIENTS AND NORMAL VOLUNTEERS: Cardiac pacemaker / cardiac or neural defibrillators. Metal fragments in the eyes. Metal plates, pins, or bolts in the head. Any magnetic implantation / implantations made from iron (ferrous products). Hearing problems. Problems using response devices. Subjects younger than 14 or older than 65 years. Subjects with 1 ) major depression, 2) bipolar disorder, or 3) psychotic disorder. Subjects taking benzodiazepines, anti-depressant or neuroleptic medications. Subjects with major acute or chronic illness, or subjects for whom sitting in a still position for an extended period of time would trigger or exacerbate a preexisting condition or cause any undue harm or discomfort. Pregnant women (steroidal hormones have been shown to influence EEG (Rupprecht et al., 2001). Patients with severe head tics or subjects who are unable to hold their head still in a scanner for at least 70 seconds.
Sites / Locations
- National Institutes of Health Clinical Center, 9000 Rockville Pike