One Month Dual Antiretroviral Prophylaxis to Prevent Resistance Mutations in Mothers Exposed to Single Dose Nevirapine
HIV Infections

About this trial
This is an interventional prevention trial for HIV Infections focused on measuring zidovudine, didanosine, Prevention of mother to child transmission of HIV, nevirapine, Thailand, Resistance, HIV, Postpartum period
Eligibility Criteria
Inclusion Criteria: Meet all pre-entry criteria; Consent to participate and to be followed for the duration of the study; Present the following laboratory values within 14 days prior to inclusion: Hemoglobin > 8.0 mg/dl Absolute neutrophil count > 1000 cells/mm3 Platelets > 100,000 cells/mm3 Serum creatinine < 1.5 mg/dl (women with a serum creatinine > 1.5 mg/dl must have a measured eight-hour urine creatinine clearance > 70 ml/min) SGPT less than 10 times the upper limit of normal Amylase less than 150/L IU (this upper limit may change slightly depending on the normal range at the hospital laboratory). Exclusion Criteria: Evidence of pre-existing fetal anomalies incompatible with life; Known hypersensitivity to any benzodiazepine or to NVP; Receipt of antiretroviral agent other than ZDV; Receipt of non-allowed concomitant treatment or contraindication to ddI Concurrent participation in another clinical trial; Women with a CD4 count <200/µL or history of oral candidiasis if they are not receiving pneumocystis carinii pneumonia (PCP) prophylaxis Any other contra-indicated drugs during ZDV+ddI treatment for the mother as well as the child (Contra-indicated drugs such as gancyclovir, isoniazid, linezolid, ethambutol, rifabutin, cidofovir are not allowed during the ZDV ddI treatment after delivery in order to prevent pharmacological interactions or overlapping toxicities.)
Sites / Locations
- Chacheongsao Hospital
- Prapokklao Hospital
- Nakornping Hospital
- Health Promotion Center Region 10
- Lamphun Hospital
- Mae Chan Hospital
- Mae Sai Hospital
- Phan Hospital
- Chiangrai Prachanukroh Hospital
- Chonburi Hospital
- Kalasin Hospital
- Phaholpolphayuhasena Hospital
- Kranuan Crown Prince Hospital
- Khon Kaen Hospital
- Regional Health Promotion Centre 6, Khon Kaen
- Srinagarind Hospital
- Lampang Hospital
- Nakhonpathom Hospital
- Maharaj Nakornratchasrima Hospital
- Nong Khai Hospital
- Pranangklao Hospital
- Chiang Kham Hospital
- Buddhachinaraj Hospital
- Ratchaburi Hospital
- Rayong Hospital
- Roi-et Hospital
- Samutsakorn Hospital
- Hat Yai Hospital
- Bhumibol Adulyadej Hospital
- Health Promotion Hospital Regional Center I
- Somdej Pranangchao Sirikit Hospital
- Samutprakarn Hospital