Rosiglitazone (Avandia®) Treatment in HIV: Its Effect on Blood Vessels

Inclusion Criteria: HIV-positive Between 30 and 70 years of age Elevated blood levels of fat On two or more anti-HIV drugs for at least12 months in a row and unlikely to change anti-HIV therapy during the study On stable regimen for at least 6 months for women taking oral contraceptive agents or hormone replacement On a stable regimen for at least 6 months for men on testosterone replacement If taking nevirapine, on therapy for at least 3 months with stable liver function tests Exclusion Criteria: Pregnancy and breastfeeding Poorly controlled diabetes Uncontrolled hypertension or clinical evidence of heart failure Any serious medical conditions, including an active AIDS-defining condition, pancreatitis, or hepatitis within 6 months prior to the study Laboratory abnormalities (see investigator) On lipid lowering agents, insulin, anabolic steroids (except for testosterone at replacement doses), oral corticosteroids at greater than replacement doses, or growth hormones History of liver reaction or severe edema associated with current thiazolidinedione History of hypersensitivity to thiazolidinedione