Oxaliplatin and Docetaxel as First-line Therapy for Advanced Non-small Cell Lung Cancer

Inclusion Criteria: Histologically or cytologically confirmed non-small-cell lung cancer (NSCLC) Patients must have measurable disease Age greater than or equal to 18 years ECOG performance score of 0, 1, or 2 Absolute neutrophil count (ANC) > 1,500 Platelets > 100,000 Serum creatinine < 1.5mg/dL Serum total bilirubin < 1.5mg/dL Alkaline phosphatase < 3 times the upper limit of normal SGOT/SGPT < 3 times the upper limit of normal Patients must be recovered from the effects of any prior surgery or RT. Patients or their legal representatives must be able to read, understand and provide informed consent to participate in the trial. Patients of childbearing potential and their partners must agree to use an effective form of contraception during the study and for 90 days following the last dose of study medications. Exclusion Criteria: Patients with an active infection > 38.5 degrees Celsius within 3 days of the first scheduled day of protocol treatment Patients with active central nervous system (CNS) metastasis. Patients with stable CNS disease, who have undergone radiotherapy at least 4 weeks prior to the planned first protocol treatment and who have been on a stable dose of corticosteroids for 2 weeks are eligible for the trial. History of prior malignancy within the past 5 years except for curatively treated basal cell carcinoma of the skin; cervical intra-epithelial neoplasm, or localized prostate cancer with a current prostate specific antigen (PSA) of < 1.0 mg/dL Patients with known hypersensitivity to any of the components of oxaliplatin or docetaxel Patients who have had prior chemotherapy for lung cancer Patients who are receiving concurrent investigational therapy or who have received investigational therapy within 30 days of the first scheduled day of protocol treatment Grade 2 peripheral neuropathy Patients who are pregnant or lactating Any other medical condition, including mental illness or substance abuse deemed by the investigator to be likely to interfere with the patients' ability to sign informed consent, cooperate and participate in the study, or interfere with the interpretation of the results History of allogeneic transplant Known HIV, hepatitis B or C (active, previously treated, or both)