rhPTH Therapy for Low Turnover Bone Fragility
Osteopetrosis
About this trial
This is an interventional treatment trial for Osteopetrosis focused on measuring low bone turnover; sclerosing bone disorders,, osteopetrosis
Eligibility Criteria
Inclusion Criteria: :patients with history of increased bone fragility by BMD criteria (T score > -1). In addition, the subjects will be enrolled only if they have clear evidence of low bone turnover as indicated by low normal levels of biochemical markers of bone turnover and finding of low bone turnover on bone biopsy. Each subject and his/her treating physician will have agreed that the rhPTH is the best treatment for the patient. Treatment with rhPTH will be considered only if the bone histomorphometry reveals a low turnover state and excludes other known forms of bone disease such as osteomalacia. Exclusion Criteria: Subjects who are pregnant or younger than 20 will be excluded. Subjects cannot have osteoporosis
Sites / Locations
- University of Chicago
Arms of the Study
Arm 1
Experimental
rhPTH
Subjects will be treated rhPTH for 12 months