Cognitive Behavioral Therapy for Depression Relapse Prevention in Children and Adolescents
Depression
About this trial
This is an interventional prevention trial for Depression focused on measuring Child, Adolescent, CBT, Drug Therapy
Eligibility Criteria
Inclusion Criteria: Diagnosis of nonpsychotic major depressive disorder at least 4 weeks prior to study entry Clinical Global Impression severity score of 4 or greater Children's Depression Rating Scale score of 40 or greater Currently attending school Willing and able to use acceptable methods of contraception, if applicable In good general health Parent or guardian willing to provide informed consent, if applicable Exclusion Criteria: History of psychotic disorders Alcohol or substance abuse or dependence within 6 months prior to study entry History of anorexia nervosa or bulimia Chronic medical illness requiring regular medication Current use of medication with psychotropic effects First-degree relatives (e.g., mother, father, sister, brother) with bipolar I disorder At risk for suicide Failure of a previous adequate treatment with fluoxetine (defined as at least 40 mg/day for 4 weeks) IQ less than 80 Pregnancy or breastfeeding
Sites / Locations
- University of Texas Southwestern Medical Center at Dallas
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
1
2
Continuation phase cognitive behavioral therapy and drug therapy for 6 more months following acute treatment response
Continuation phase drug therapy only for 6 more months following acute treatment response