VAST - Ventricular Arrhythmia Suppression Trial

Inclusion Criteria: Patients who receive a commercially available Guidant PRIZM, PRIZM 2, or VITALITY AVT ICD Patients who sign and date a Patient Informed Consent prior to study enrollment Patients who remain in the clinical care of physicians of their implanting center Exclusion Criteria: Patients who have chronic atrial fibrillation. Paroxysms of AF are not an exclusion criterion, but the patient must be in normal sinus rhythm at the time of randomization. If history of AF is unknown or uncertain, or the patient was recently cardioverted, there must be at least 23 hours of normal sinus rhythm within the 24 hour period preceding randomization Patients who previously had an ICD Patients with current indications for cardiac resynchronization therapy with defibrillation (CRT-D) Patients whose life expectancy is less than 12 months due to other medical conditions Patients who are expected to receive a heart transplant during the duration of the study Patients who have or who are likely to receive a tricuspid or other valve prosthesis Patients who are currently enrolled in another investigational study of active medical therapy. Each instance should be brought to Guidant's Clinical Application Research Studies (CARS) group to determine eligibility Patients who are younger than 18 years of age Patients who are mentally incompetent and cannot give a Patient Informed Consent or participate in the study